The growth inhibitor of African green monkey (BSC-1) cells is transforming growth factors .beta.1 and .beta.2

Biochemistry ◽  
1989 ◽  
Vol 28 (8) ◽  
pp. 3442-3447 ◽  
Author(s):  
John M. McPherson ◽  
Steven J. Sawamura ◽  
Yasushi Ogawa ◽  
Kelly Dineley ◽  
Pedro Carrillo ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Inhibitor ◽  
African Green Monkey ◽  
Transforming Growth Factors ◽  
Green Monkey ◽  
Beta 2

scholarly journals Expression of transforming growth factors beta-1, beta 2 and beta 3 in human bladder carcinomas

1997 ◽  
Vol 75 (12) ◽  
pp. 1753-1760 ◽  
Author(s):  
IE Eder ◽  
A Stenzl ◽  
A Hobisch ◽  
MV Cronauer ◽  
G Bartsch ◽  
...  
Keyword(s):  
Growth Factors ◽  
Transforming Growth Factors ◽  
Human Bladder ◽  
Beta 2 ◽  
Bladder Carcinomas

Elevated Levels of Transforming Growth Factors Beta 2 and Beta 3 in Lambdoid Sutures From Children with Persistent Plagiocephaly

1997 ◽  
Vol 34 (4) ◽  
pp. 331-336 ◽  
Author(s):  
Kant Y. Lin ◽  
Amber A. Nolen ◽  
Thomas J. Gampper ◽  
John A. Jane ◽  
Lynne A. Opperman ◽  
...  
Keyword(s):  
Growth Factors ◽  
Transforming Growth Factors ◽  
Beta 2

scholarly journals Type beta transforming growth factors promote interleukin-3 (IL-3)- dependent differentiation of human basophils but inhibit IL-3-dependent differentiation of human eosinophils

Blood ◽  
1992 ◽  
Vol 80 (3) ◽  
pp. 634-641 ◽  
Author(s):  
C Sillaber ◽  
K Geissler ◽  
R Scherrer ◽  
R Kaltenbrunner ◽  
P Bettelheim ◽  
...  
Keyword(s):  
Growth Factors ◽  
Culture System ◽  
Transforming Growth Factors ◽  
Tgf Beta ◽  
Ifn Gamma ◽  
Interleukin 3 ◽  
Ifn Alpha ◽  
Beta 2 ◽  
Dependent Growth ◽  
Human Basophils

Abstract Basophils and eosinophils share a common differentiation pathway. Factors regulating terminal commitment toward one cell type, however, have so far not been defined. Interleukin-3 (IL-3) is a potent differentiation factor for both human eosinophils and basophils. In the present study, the effects of various recombinant human (rh) growth regulators on IL-3-dependent growth of eosinophils and basophils were studied in a bone marrow (BM) suspension culture system (normal donors, n = 13). We found that type beta transforming growth factors (TGFs) lead to a significant increase in the absolute numbers of basophils in BM cultures grown in the presence of IL-3 (day 14 of culture; IL-3: 133 +/- 20 v IL-3 + TGF-beta 1: 231 +/- 28 x 10(3)/mL [P less than .01]) and to an increase in the total histamine values (IL-3: 72.6 +/- 22.2 v IL-3 + TGF-beta 1: 142.9 +/- 37.3 ng/mL [P less than .015]) compared with rhIL-3 alone. In contrast, type beta TGFs were found to inhibit the IL-3-dependent growth of eosinophils (IL-3: 170.4 +/- 37.2 v IL-3 + TGF-beta 1: 16.7 +/- 5.2 x 10(3)/mL [P less than .01]) and formation of eosinophil cationic protein in the same culture system. The effect of TGF-beta 1 (and TGF-beta 2) on IL-3-dependent differentiation of basophils and eosinophils was dose- and time-dependent (maximum effects observed with 1 to 10 ng/mL of rhTGF-beta 1 or TGF-beta 2) and could be neutralized by an antibody specific for TGF-beta 1. In contrast to the TGFs, interferon-alpha (IFN-alpha) and IFN-gamma were found to downregulate IL-3-dependent formation of both basophils (IL-3: 167 +/- 33 v IL-3 + IFN-alpha: 67 +/- 25 v IL-3 + IFN-gamma: 65 +/- 33 x 10(3)/mL [P less than .01]) and eosinophils (IL-3: 239 +/- 5 v IL-3 + IFN-alpha: 81 +/- 4 v IL-3 + IFN-gamma: 67 +/- 17 x 10(3)/mL [P less than .05]) in our culture system. Type beta TGFs as well as the IFNs failed to directly induce differentiation of human basophils or eosinophils in the absence of other growth factors. Together, these results show that type beta TGFs and IFNs are potent regulators of cytokine-dependent growth and differentiation of human allergic effector cells.

Transforming Growth Factors-beta 1 and beta 2 in Serum and Urine from Patients with Bladder Carcinoma

1996 ◽  
Vol 156 (3) ◽  
pp. 953-957 ◽  
Author(s):  
Iris E. Eder ◽  
Arnulf Stenzl ◽  
Alfred Hobisch ◽  
Marcus V. Cronauer ◽  
Georg Bartsch ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bladder Carcinoma ◽  
Transforming Growth Factors ◽  
Beta 2 ◽  
Serum And Urine

scholarly journals Type beta transforming growth factors promote interleukin-3 (IL-3)- dependent differentiation of human basophils but inhibit IL-3-dependent differentiation of human eosinophils

Blood ◽  
1992 ◽  
Vol 80 (3) ◽  
pp. 634-641 ◽  
Author(s):  
C Sillaber ◽  
K Geissler ◽  
R Scherrer ◽  
R Kaltenbrunner ◽  
P Bettelheim ◽  
...  
Keyword(s):  
Growth Factors ◽  
Culture System ◽  
Transforming Growth Factors ◽  
Tgf Beta ◽  
Ifn Gamma ◽  
Interleukin 3 ◽  
Ifn Alpha ◽  
Beta 2 ◽  
Dependent Growth ◽  
Human Basophils

Basophils and eosinophils share a common differentiation pathway. Factors regulating terminal commitment toward one cell type, however, have so far not been defined. Interleukin-3 (IL-3) is a potent differentiation factor for both human eosinophils and basophils. In the present study, the effects of various recombinant human (rh) growth regulators on IL-3-dependent growth of eosinophils and basophils were studied in a bone marrow (BM) suspension culture system (normal donors, n = 13). We found that type beta transforming growth factors (TGFs) lead to a significant increase in the absolute numbers of basophils in BM cultures grown in the presence of IL-3 (day 14 of culture; IL-3: 133 +/- 20 v IL-3 + TGF-beta 1: 231 +/- 28 x 10(3)/mL [P less than .01]) and to an increase in the total histamine values (IL-3: 72.6 +/- 22.2 v IL-3 + TGF-beta 1: 142.9 +/- 37.3 ng/mL [P less than .015]) compared with rhIL-3 alone. In contrast, type beta TGFs were found to inhibit the IL-3-dependent growth of eosinophils (IL-3: 170.4 +/- 37.2 v IL-3 + TGF-beta 1: 16.7 +/- 5.2 x 10(3)/mL [P less than .01]) and formation of eosinophil cationic protein in the same culture system. The effect of TGF-beta 1 (and TGF-beta 2) on IL-3-dependent differentiation of basophils and eosinophils was dose- and time-dependent (maximum effects observed with 1 to 10 ng/mL of rhTGF-beta 1 or TGF-beta 2) and could be neutralized by an antibody specific for TGF-beta 1. In contrast to the TGFs, interferon-alpha (IFN-alpha) and IFN-gamma were found to downregulate IL-3-dependent formation of both basophils (IL-3: 167 +/- 33 v IL-3 + IFN-alpha: 67 +/- 25 v IL-3 + IFN-gamma: 65 +/- 33 x 10(3)/mL [P less than .01]) and eosinophils (IL-3: 239 +/- 5 v IL-3 + IFN-alpha: 81 +/- 4 v IL-3 + IFN-gamma: 67 +/- 17 x 10(3)/mL [P less than .05]) in our culture system. Type beta TGFs as well as the IFNs failed to directly induce differentiation of human basophils or eosinophils in the absence of other growth factors. Together, these results show that type beta TGFs and IFNs are potent regulators of cytokine-dependent growth and differentiation of human allergic effector cells.

Transforming Growth Factors-beta 1 and beta 2 in Serum and Urine from Patients with Bladder Carcinoma

1996 ◽  
pp. 953-957 ◽  
Author(s):  
Iris E. Eder ◽  
Arnulf Stenzl ◽  
Alfred Hobisch ◽  
Marcus V. Cronauer ◽  
Georg Bartsch ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bladder Carcinoma ◽  
Transforming Growth Factors ◽  
Beta 2 ◽  
Serum And Urine
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