Polypeptide chain fold of human transforming growth factor .alpha. analogous to those of mouse and human epidermal growth factors as studied by two-dimensional proton NMR

Biochemistry ◽  
1989 ◽  
Vol 28 (3) ◽  
pp. 953-958 ◽  
Author(s):  
Daisuke Kohda ◽  
Ichio Shimada ◽  
Tetsuo Miyake ◽  
Toru Fuwa ◽  
Fuyuhiko Inagaki
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Polypeptide Chain ◽  
Proton Nmr ◽  
Transforming Growth Factor Alpha ◽  
Two Dimensional ◽  
Epidermal Growth Factors ◽  
Epidermal Growth ◽  
Factor Alpha

Growth factors and metanephrogenesis

1992 ◽  
Vol 262 (4) ◽  
pp. F523-F532 ◽  
Author(s):  
M. R. Hammerman ◽  
S. A. Rogers ◽  
G. Ryan
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Kidney Development ◽  
Transforming Growth Factor ◽  
Polypeptide Growth Factors ◽  
Metanephric Kidney ◽  
Epidermal Growth ◽  
Factor Alpha ◽  
Editorial Review

The formation of all organs during embryogenesis, including kidney, is dependent on the timed and sequential expression of a number of polypeptide growth factors. Synthesis and actions of one or more members of the insulin-like growth factor, epidermal growth factor/transforming growth factor-alpha, transforming growth factor-beta, platelet-derived growth factor, fibroblast growth factor, and nerve growth factor families have been characterized in the developing metanephric kidney. Studies originating from a number of laboratories have defined the localization of growth factor mRNAs, receptors and peptides, have delineated patterns of growth factor synthesis, and have established the growth factor dependency of embryonic kidney development. The results of these investigations will be summarized in this editorial review and integrated within the broader context of growth factor cellular physiology and growth factor expression in nonrenal systems.

Sign in / Sign up

Export Citation Format

Share Document