Inactivation of the ribonucleoside triphosphate reductase from Lactobacillus leichmannii by 2'-chloro-2'-deoxyuridine 5'-triphosphate: a 3'-2' hydrogen transfer during the formation of 3'-keto-2'-deoxyuridine 5'-triphosphate

Gary W. Ashley; Georgianna Harris; JoAnne Stubbe

doi:10.1021/bi00420a038

Inactivation of the ribonucleoside triphosphate reductase from Lactobacillus leichmannii by 2'-chloro-2'-deoxyuridine 5'-triphosphate: a 3'-2' hydrogen transfer during the formation of 3'-keto-2'-deoxyuridine 5'-triphosphate

Biochemistry ◽

10.1021/bi00420a038 ◽

1988 ◽

Vol 27 (20) ◽

pp. 7841-7845 ◽

Cited By ~ 6

Author(s):

Gary W. Ashley ◽

Georgianna Harris ◽

JoAnne Stubbe

Keyword(s):

Hydrogen Transfer ◽

Ribonucleoside Triphosphate ◽

Lactobacillus Leichmannii

Download Full-text

Factors influencing the level of cobamide-dependent ribonucleoside triphosphate reductase in Lactobacillus leichmannii

Biochemical and Biophysical Research Communications ◽

10.1016/0006-291x(65)90423-7 ◽

1965 ◽

Vol 21 (1) ◽

pp. 40-48 ◽

Cited By ~ 5

Author(s):

R.K. Ghambeer ◽

R.L. Blakley

Keyword(s):

Factors Influencing ◽

Ribonucleoside Triphosphate ◽

Lactobacillus Leichmannii

Download Full-text

Hydrogen abstraction from thiols by adenosyl radicals: chemical precedent for thiyl radical formation, the first catalytic step in ribonucleoside triphosphate reductase from Lactobacillus leichmannii

Journal of Inorganic Biochemistry ◽

10.1016/s0162-0134(99)00224-x ◽

2000 ◽

Vol 78 (2) ◽

pp. 149-160 ◽

Cited By ~ 2

Author(s):

Jeanne M Sirovatka ◽

Richard G Finke

Keyword(s):

Hydrogen Abstraction ◽

Radical Formation ◽

Thiyl Radical ◽

Ribonucleoside Triphosphate ◽

Lactobacillus Leichmannii

Download Full-text

The function of adenosylcobalamin in the mechanism of ribonucleoside triphosphate reductase from Lactobacillus leichmannii

Current Opinion in Chemical Biology ◽

10.1016/s1367-5931(98)80097-5 ◽

1998 ◽

Vol 2 (5) ◽

pp. 650-655 ◽

Cited By ~ 27

Author(s):

Christopher C Lawrence ◽

JoAnne Stubbe

Keyword(s):

Ribonucleoside Triphosphate ◽

Lactobacillus Leichmannii

Download Full-text

On the mechanism of ribonucleoside triphosphate reductase from Lactobacillus leichmannii. Evidence for 3' C–H bond cleavage.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)69331-2 ◽

1981 ◽

Vol 256 (10) ◽

pp. 4843-4846

Author(s):

J. Stubbe ◽

D. Ackles ◽

R. Segal ◽

R.L. Blakley

Keyword(s):

Bond Cleavage ◽

Ribonucleoside Triphosphate ◽

Lactobacillus Leichmannii

Download Full-text

Thermolysis of coenzymes B12 at physiological temperatures: activation parameters for cobalt–carbon bond homolysis and a quantitative analysis of the perturbation of the homolysis equilibrium by the ribonucleoside triphosphate reductase from Lactobacillus leichmannii

Journal of Inorganic Biochemistry ◽

10.1016/s0162-0134(99)00190-7 ◽

1999 ◽

Vol 77 (3-4) ◽

pp. 185-195 ◽

Cited By ~ 21

Author(s):

Kenneth L Brown ◽

Xiang Zou

Keyword(s):

Quantitative Analysis ◽

Activation Parameters ◽

Carbon Bond ◽

Bond Homolysis ◽

Ribonucleoside Triphosphate ◽

Lactobacillus Leichmannii

Download Full-text

Ribonucleoside Triphosphate Reductase from Lactobacillus leichmannii: Kinetic Evaluation of a Series of Adenosylcobalamin Competitive Inhibitors, [ω-(Adenosin-5′-O-yl)alkyl]cobalamins, Which Mimic the Post Co-C Homolysis Intermediate

Bioorganic Chemistry ◽

10.1006/bioo.1999.1149 ◽

1999 ◽

Vol 27 (6) ◽

pp. 451-462 ◽

Cited By ~ 3

Author(s):

Robert K. Suto ◽

László Poppe ◽

János Rétey ◽

Richard G. Finke

Keyword(s):

Kinetic Evaluation ◽

Competitive Inhibitors ◽

Ribonucleoside Triphosphate ◽

Lactobacillus Leichmannii

Download Full-text

Substrate and effector binding to ribonucleoside triphosphate reductase of Lactobacillus leichmannii

Biochemistry ◽

10.1021/bi00701a004 ◽

1974 ◽

Vol 13 (4) ◽

pp. 654-661 ◽

Cited By ~ 41

Author(s):

Alice K. Chen ◽

Ashok Bhan ◽

Sarah Hopper ◽

Richard Abrams ◽

James S. Franzen

Keyword(s):

Ribonucleoside Triphosphate ◽

Lactobacillus Leichmannii ◽

Effector Binding

Download Full-text

[32] Ribonucleoside triphosphate reductase from Lactobacillus leichmannii

Methods in Enzymology - Purine and Pyrimidine Nucleotide Metabolism ◽

10.1016/s0076-6879(78)51034-3 ◽

1978 ◽

pp. 246-259 ◽

Cited By ~ 25

Author(s):

Raymond L. Blakley

Keyword(s):

Ribonucleoside Triphosphate ◽

Lactobacillus Leichmannii

Download Full-text

Investigating the intermediates in the reaction of ribonucleoside triphosphate reductase from Lactobacillus leichmannii: An application of HF EPR–RFQ technology

Journal of Magnetic Resonance ◽

10.1016/j.jmr.2011.08.030 ◽

2011 ◽

Vol 213 (1) ◽

pp. 32-45 ◽

Cited By ~ 11

Author(s):

Julia Manzerova ◽

Vladimir Krymov ◽

Gary J. Gerfen

Keyword(s):

Ribonucleoside Triphosphate ◽

Lactobacillus Leichmannii

Download Full-text

Inactivation of the Lactobacillus leichmannii ribonucleoside triphosphate reductase by 2'-chloro-2'-deoxyuridine 5'-triphosphate: stoichiometry of inactivation, site of inactivation, and mechanism of the protein chromophore formation

Biochemistry ◽

10.1021/bi00412a017 ◽

1988 ◽

Vol 27 (12) ◽

pp. 4305-4310 ◽

Cited By ~ 11

Author(s):

Gary W. Ashley ◽

Georgianna Harris ◽

JoAnne Stubbe

Keyword(s):

Ribonucleoside Triphosphate ◽

Lactobacillus Leichmannii

Download Full-text