Mitochondrial DNA polymerase from Drosophila melanogaster embryos: kinetics, processivity, and fidelity of DNA polymerization

Biochemistry ◽  
1988 ◽  
Vol 27 (16) ◽  
pp. 6046-6054 ◽  
Author(s):  
Catherine M. Wernette ◽  
Michael C. Conway ◽  
Laurie S. Kaguni
Keyword(s):  
Mitochondrial Dna ◽  
Drosophila Melanogaster ◽  
Dna Polymerase ◽  
Dna Polymerization ◽  
Mitochondrial Dna Polymerase

scholarly journals The tamas Gene, Identified as a Mutation That Disrupts Larval Behavior in Drosophila melanogaster, Codes for the Mitochondrial DNA Polymerase Catalytic Subunit (DNApol-γ125)

Genetics ◽  
1999 ◽  
Vol 153 (4) ◽  
pp. 1809-1824 ◽  
Author(s):  
Balaji Iyengar ◽  
John Roote ◽  
Ana Regina Campos
Keyword(s):  
Mitochondrial Dna ◽  
Drosophila Melanogaster ◽  
Mutant Strain ◽  
Dna Polymerase ◽  
Complementation Group ◽  
Behavioral Changes ◽  
Catalytic Subunit ◽  
Primary Deficit ◽  
Mitochondrial Dna Polymerase ◽  
Food Substrate

AbstractFrom a screen of pupal lethal lines of Drosophila melanogaster we identified a mutant strain that displayed a reproducible reduction in the larval response to light. Moreover, this mutant strain showed defects in the development of the adult visual system and failure to undergo behavioral changes characteristic of the wandering stage. The foraging third instar larvae remained in the food substrate for a prolonged period and died at or just before pupariation. Using a new assay for individual larval photobehavior we determined that the lack of response to light in these mutants was due to a primary deficit in locomotion. The mutation responsible for these phenotypes was mapped to the lethal complementation group l(2)34Dc, which we renamed tamas (translated from Sanskrit as “dark inertia”). Sequencing of mutant alleles demonstrated that tamas codes for the mitochondrial DNA polymerase catalytic subunit (DNApol-γ125).

scholarly journals A DNA polymerization-independent role for mitochondrial DNA polymerase I-like protein C in African trypanosomes

2020 ◽  
Vol 133 (9) ◽  
pp. jcs233072 ◽  
Author(s):  
Jonathan C. Miller ◽  
Stephanie B. Delzell ◽  
Jeniffer Concepción-Acevedo ◽  
Michael J. Boucher ◽  
Michele M. Klingbeil
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Protein C ◽  
Dna Polymerase I ◽  
African Trypanosomes ◽  
Dna Polymerization ◽  
Polymerase I ◽  
Mitochondrial Dna Polymerase

Human Mitochondrial DNA Polymerase Holoenzyme: Reconstitution and Characterization†

Biochemistry ◽  
2000 ◽  
Vol 39 (7) ◽  
pp. 1702-1708 ◽  
Author(s):  
Allison A. Johnson ◽  
Yu-chih Tsai ◽  
Steven W. Graves ◽  
Kenneth A. Johnson
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Human Mitochondrial Dna ◽  
Mitochondrial Dna Polymerase
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