Synthetic branched-chain analogs of distearoylphosphatidylcholine: structure-activity relationship in inhibiting and activating protein kinase C

Biochemistry ◽  
1988 ◽  
Vol 27 (13) ◽  
pp. 4607-4612 ◽  
Author(s):  
Paul A. Charp ◽  
Qingzhong Zhou ◽  
Mervin G. Wood ◽  
Robert L. Raynor ◽  
Fredric M. Menger ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Kinase C ◽  
Structure Activity ◽  
Branched Chain

Design, synthesis, and structure–activity relationship of new isobenzofuranone ligands of protein kinase C

2004 ◽  
Vol 14 (11) ◽  
pp. 2963-2967 ◽  
Author(s):  
Yoshiyasu Baba ◽  
Yosuke Ogoshi ◽  
Go Hirai ◽  
Takeshi Yanagisawa ◽  
Kumiko Nagamatsu ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Kinase C ◽  
Structure Activity ◽  
Relationship Of

Design, Synthesis, and Structure—Activity Relationship of New Isobenzofuranone Ligands of Protein Kinase C.

ChemInform ◽  
2004 ◽  
Vol 35 (38) ◽  
Author(s):  
Yoshiyasu Baba ◽  
Yosuke Ogoshi ◽  
Go Hirai ◽  
Takeshi Yanagisawa ◽  
Kumiko Nagamatsu ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Kinase C ◽  
Structure Activity ◽  
Relationship Of

scholarly journals Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication

Molecules ◽  
2019 ◽  
Vol 24 (12) ◽  
pp. 2336 ◽  
Author(s):  
Simon Remy ◽  
Marc Litaudon
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Virus Replication ◽  
Mechanism Of Action ◽  
Chikungunya Virus ◽  
Cytopathic Effect ◽  
Structural Diversity ◽  
Biological Properties ◽  
Kinase C ◽  
Structure Activity

Macrocyclic diterpenoids produced by plants of the Euphorbiaceae family are of considerable interest due to their high structural diversity; and their therapeutically relevant biological properties. Over the last decade many studies have reported the ability of macrocyclic diterpenoids to inhibit in cellulo the cytopathic effect induced by the chikungunya virus. This review; which covers the years 2011 to 2019; lists all macrocyclic diterpenoids that have been evaluated for their ability to inhibit viral replication. The structure–activity relationships and the probable involvement of protein kinase C in their mechanism of action are also detailed.

scholarly journals Quantitative Structure-Activity Relationship Studies for Potential Rho-Associated Protein Kinase Inhibitors

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Giovanna Cardoso Gajo ◽  
Tamiris Maria de Assis ◽  
Letícia Cristina Assis ◽  
Teodorico Castro Ramalho ◽  
Elaine Fontes Ferreira da Cunha
Keyword(s):  
Protein Kinase ◽  
Kinase Inhibitors ◽  
Quantitative Structure Activity Relationship ◽  
Structure Activity Relationship ◽  
Protein Kinase Inhibitors ◽  
Activity Relationship ◽  
Quantitative Structure ◽  
Qsar Analysis ◽  
Structure Activity ◽  
New Compounds

A series of pyridylthiazole derivatives developed by Lawrence et al. as Rho-associated protein kinase inhibitors were subjected to four-dimensional quantitative structure-activity relationship (4D-QSAR) analysis. The models were generated applying genetic algorithm (GA) optimization combined with partial least squares (PLS) regression. The best model presented validation values ofr2=0.773,qCV2=0.672,rpred2=0.503,Δrm2=0.197,rm test2⁡⁡=0.520,rY-rand2=0.19, andRp2=0.590. Furthermore, analyzing the descriptors it was possible to propose new compounds that predicted higher inhibitory concentration values than the most active compound of the series.

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