The metabolism of excess methionine in the liver of the intact rat: an in vivo deuterium NMR study

Biochemistry ◽  
1987 ◽  
Vol 26 (22) ◽  
pp. 7166-7172 ◽  
Author(s):  
Robert E. London ◽  
Scott A. Gabel ◽  
Alex Funk
Keyword(s):  
Deuterium Nmr ◽  
Nmr Study

scholarly journals Triglyceride metabolism in 3T3-L1 cells. An in vivo 13C NMR study.

1992 ◽  
Vol 267 (16) ◽  
pp. 11168-11175
Author(s):  
M.R. Soma ◽  
M.P. Mims ◽  
M.V. Chari ◽  
D Rees ◽  
J.D. Morrisett
Keyword(s):  
13C Nmr ◽  
Triglyceride Metabolism ◽  
Nmr Study

Backbone dynamics of poly(isopropyl acrylate) in chloroform. A deuterium NMR study

1984 ◽  
Vol 17 (12) ◽  
pp. 2837-2846 ◽  
Author(s):  
Frank D. Blum ◽  
B. Durairaj ◽  
A. S. Padmanabhan
Keyword(s):  
Backbone Dynamics ◽  
Deuterium Nmr ◽  
Nmr Study

A deuterium NMR study of orientational order in camphor

1979 ◽  
Vol 67 (2-3) ◽  
pp. 459-462 ◽  
Author(s):  
Roderick E. Wasylishen ◽  
Brian A. Pettitt ◽  
John S. Lewis
Keyword(s):  
Orientational Order ◽  
Deuterium Nmr ◽  
Nmr Study

scholarly journals In Vivo 2H-NMR Study of the Action of Antibacterial Agents on Escherichia Coli Membranes

2011 ◽  
Vol 100 (3) ◽  
pp. 627a
Author(s):  
Catherine Tardy-Laporte ◽  
Alexandre A. Arnold ◽  
Isabelle Marcotte
Keyword(s):  
Escherichia Coli ◽  
Antibacterial Agents ◽  
2H Nmr ◽  
Nmr Study

scholarly journals Response of Cisplatin Resistant Skov-3 Cells to [Pt(O,O′-Acac)(γ-Acac)(DMS)] Treatment Revealed by a Metabolomic 1H-NMR Study

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2301 ◽  
Author(s):  
Federica De Castro ◽  
Michele Benedetti ◽  
Giovanna Antonaci ◽  
Laura Del Coco ◽  
Sandra De Pascali ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
1H Nmr ◽  
Mechanism Of Action ◽  
Culture Media ◽  
Epithelial Ovarian Carcinoma ◽  
Multivariate Statistical ◽  
Nmr Study ◽  
First Time

The novel [Pt(O,O′-acac)(γ-acac)(DMS)], Ptac2S, Pt(II) complex has recently gained increasing attention as a potential anticancer agent for its pharmacological activity shown in different tumor cell lines, studied both in vitro and in vivo. The mechanism of action of Ptac2S, operating on non-genomic targets, is known to be very different from that of cis-[PtCl2(NH3)2], cisplatin, targeting nucleic acids. In this work, we evaluated the cytotoxicity of Ptac2S on the cisplatin resistant Epithelial Ovarian Carcinoma (EOC), SKOV-3 cells, by the MTT assay. A 1H-NMR metabolomic approach coupled with multivariate statistical analysis was used for the first time for Ptac2S to figure out the biological mechanisms of action of the complex. The metabolic variations of intracellular metabolites and the composition of the corresponding extracellular culture media were compared to those of cisplatin (cells were treated at the IC50 doses of both drugs). The reported comparative metabolomic analysis revealed a very different metabolic profile between Ptac2S and cisplatin treated samples, thus confirming the different mechanism of action of Ptac2S also in the Epithelial Ovarian Carcinoma (EOC), SKOV-3 cells line. In particular, higher levels of pyruvate were observed in Ptac2S treated, with respect to cisplatin treated, cells (in both aqueous and culture media). In addition, a very different lipid expression resulted after the exposure to the two drugs (Ptac2S and cisplatin). These results suggest a possible explanation for the Ptac2S ability to circumvent cisplatin resistance in SKOV-3 cells.

Deuterium NMR study of mobility and fluctuations in nematic and isotropic elastomers

2009 ◽  
Vol 131 (7) ◽  
pp. 074903 ◽  
Author(s):  
G. Feio ◽  
J. L. Figueirinhas ◽  
A. R. Tajbakhsh ◽  
E. M. Terentjev
Keyword(s):  
Deuterium Nmr ◽  
Nmr Study
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