Primary structure of tetranectin, a plasminogen kringle 4 binding plasma protein: homology with asialoglycoprotein receptors and cartilage proteoglycan core protein

Biochemistry ◽  
1987 ◽  
Vol 26 (21) ◽  
pp. 6757-6764 ◽  
Author(s):  
Jannie Fuhlendorff ◽  
Inge Clemmensen ◽  
Staffan Magnusson
Keyword(s):  
Plasma Protein ◽  
Primary Structure ◽  
Core Protein ◽  
Protein Homology ◽  
Cartilage Proteoglycan ◽  
And Cartilage ◽  
Binding Plasma Protein

scholarly journals Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones.

1987 ◽  
Vol 262 (36) ◽  
pp. 17757-17767 ◽  
Author(s):  
K Doege ◽  
M Sasaki ◽  
E Horigan ◽  
J R Hassell ◽  
Y Yamada
Keyword(s):  
Primary Structure ◽  
Core Protein ◽  
Cdna Clones ◽  
Cartilage Proteoglycan ◽  
Complete Primary Structure

Further characterization and immunological studies of human sex steroid binding plasma protein

1979 ◽  
Vol 11 (1) ◽  
pp. 253-259 ◽  
Author(s):  
Christine Mercier-Bodard ◽  
Jack-Michel Renoir ◽  
Etienne-Emile Baulieu
Keyword(s):  
Plasma Protein ◽  
Sex Steroid ◽  
Steroid Binding ◽  
Binding Plasma Protein

Comparison of the cartilage proteoglycan core protein synthesized by chondrocytes of different ages

1991 ◽  
Vol 25 (3-4) ◽  
pp. 311-320 ◽  
Author(s):  
Stephen E. Haynesworth ◽  
David A. Carrino ◽  
Arnold I. Caplan
Keyword(s):  
Core Protein ◽  
Cartilage Proteoglycan ◽  
Different Ages

scholarly journals Leucocyte infiltration and cartilage proteoglycan loss in immune arthritis in the rabbit

1988 ◽  
Vol 95 (1) ◽  
pp. 169-176 ◽  
Author(s):  
E.R. Pettipher ◽  
B. Henderson ◽  
S. Moncada ◽  
G.A. Higgs
Keyword(s):  
Cartilage Proteoglycan ◽  
Leucocyte Infiltration ◽  
And Cartilage

Variation with age in the levels of sex-steroid-binding plasma protein as determined by radioimmunoassay

1984 ◽  
Vol 106 (3) ◽  
pp. 428-432 ◽  
Author(s):  
Yoshiyuki Maruyama ◽  
Norihiko Aoki ◽  
Yasuyuki Suzuki ◽  
Hyogo Sinohara ◽  
Toshio Yamamoto
Keyword(s):  
Pregnant Women ◽  
Plasma Protein ◽  
Sexual Difference ◽  
Sex Steroid ◽  
Blood Levels ◽  
Men And Women ◽  
Adult Men ◽  
Steroid Binding ◽  
Normal Men ◽  
Binding Plasma Protein

Abstract. A radioimmunoassay for human sex-steroidbinding plasma protein (SBP) was developed. With this assay, SBP was determined in sera of 138 normal men and 169 non-pregnant women, ranging in age from 11 to 87 years. The results indicate (i) that SBP levels in both sexes increase gradually with age up to mid-eighties, (ii) that the average levels in mid-eighties are approximately twice those in early twenties, and (iii) that the average levels in women are about twice as high as those in men of corresponding age. These results may also account for the discrepancies in the previous papers regarding the normal blood levels and sexual difference of SBP in adult men and women.

Primary structure of the variable regions of a monoclonal antibody MUSE11 recognizing the tandem repeat domain of a mucin core protein, MUC1

1993 ◽  
Vol 7 (2) ◽  
pp. 100-104 ◽  
Author(s):  
Yuji Hinoda ◽  
Yoshiaki Arimura ◽  
Fumio Itoh ◽  
Masaaki Adachi ◽  
Masayuki Tsujisaki ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Tandem Repeat ◽  
Primary Structure ◽  
Core Protein ◽  
Variable Regions ◽  
Repeat Domain ◽  
Mucin Core Protein

scholarly journals Age-related changes in protein-related epitopes of human articular-cartilage proteoglycans

1986 ◽  
Vol 236 (1) ◽  
pp. 71-75 ◽  
Author(s):  
T T Glant ◽  
K Mikecz ◽  
P J Roughley ◽  
E Buzás ◽  
A R Poole
Keyword(s):  
Core Protein ◽  
Buoyant Density ◽  
Human Articular Cartilage ◽  
Human Cartilage ◽  
Keratan Sulphate ◽  
Cartilage Proteoglycan ◽  
Age Related ◽  
Age Dependent ◽  
Old Adult ◽  
Cartilage Proteoglycans

Monoclonal antibodies were prepared that recognize different age-related epitopes on proteoglycan subunits of high buoyant density isolated from human epiphysial and articular cartilages. Antibody EFG-4 (IgG1) recognizes a proteinase-sensitive segment associated with the core protein. Antibody BCD-4 (IgG1) reacts with keratan sulphate bound to core protein. Both epitopes are minimally expressed in foetal cartilage and increase with age after birth to become maximally expressed in adult cartilage by about 30 years of age. In contrast, monoclonal antibody alpha HFPG-846 (IgM) recognizes a core-protein-related epitope that is maximally expressed in young foetal cartilage, declines up to birth and thereafter and is almost absent after about 30 years of age. Antibody alpha HFPG-846 was used to isolate by immuno-affinity chromatography two subpopulations of proteoglycan subunits from a 16-year-old-human cartilage proteoglycan subunit preparation. Only the antibody-unbound population showed a significant reaction with antibodies EGF-4 and BCD-4. The amino acid and carbohydrate compositions of these proteoglycan fractions were different, and one (antibody-bound) resembled those of foetal and the other (antibody-unbound) resembled those of adult proteoglycans isolated from 24-27-week-old-foetal and 52-56-year-old-adult cartilage respectively. These observations demonstrate that human cartilages contain at least two chemically and immunochemically distinct populations of proteoglycans, the proportions and content of which are age-dependent. It is likely that these populations represent the products of different genes, though their heterogeneity may be compounded by the result of different post-translation modifications.

Sign in / Sign up

Export Citation Format

Share Document