Stratum corneum lipid phase transitions and water barrier properties

Biochemistry ◽  
1987 ◽  
Vol 26 (8) ◽  
pp. 2382-2388 ◽  
Author(s):  
Guia M. Golden ◽  
Donald B. Guzek ◽  
Alane E. Kennedy ◽  
James E. McKie ◽  
Russell O. Potts
Keyword(s):  
Phase Transitions ◽  
Stratum Corneum ◽  
Barrier Properties ◽  
Lipid Phase ◽  
Water Barrier ◽  
Lipid Phase Transitions ◽  
Stratum Corneum Lipid

Local Temperature Rises Influence In Vivo Electroporation Pore Development: A Numerical Stratum Corneum Lipid Phase Transition Model

2007 ◽  
Vol 129 (5) ◽  
pp. 712-721 ◽  
Author(s):  
S. M. Becker ◽  
A. V. Kuznetsov
Keyword(s):  
Phase Transition ◽  
Phase Transitions ◽  
Stratum Corneum ◽  
Joule Heating ◽  
Lipid Phase ◽  
Transition Model ◽  
Lipid Phase Transition ◽  
Stratum Corneum Lipid ◽  
Lipid Melting

Electroporation is an approach used to enhance transdermal transport of large molecules in which the skin is exposed to a series of electric pulses. Electroporation temporarily destabilizes the structure of the outer skin layer, the stratum corneum, by creating microscopic pores through which agents, ordinarily unable to pass into the skin, are able to pass through this outer barrier. Long duration electroporation pulses can cause localized temperature rises, which result in thermotropic phase transitions within the lipid bilayer matrix of the stratum corneum. This paper focuses on electroporation pore development resulting from localized Joule heating. This study presents a theoretical model of electroporation, which incorporates stratum corneum lipid melting with electrical and thermal energy equations. A transient finite volume model is developed representing electroporation of in vivo human skin, in which stratum corneum lipid phase transitions are modeled as a series of melting processes. The results confirm that applied voltage to the skin results in high current densities within the less resistive regions of the stratum corneum. The model captures highly localized Joule heating within the stratum corneum and subsequent temperature rises, which propagate radially outward. Electroporation pore development resulting from the decrease in resistance associated with lipid melting is captured by the lipid phase transition model. As the effective pore radius grows, current density and subsequent Joule heating values decrease.

Lipid phase transitions measured in intact cells with fourier transform infrared spectroscopy

Cryobiology ◽  
1989 ◽  
Vol 26 (1) ◽  
pp. 76-84 ◽  
Author(s):  
John H. Crowe ◽  
Folkert A. Hoekstra ◽  
Lois M. Crowe ◽  
Thomas J. Anchordoguy ◽  
Erma Drobnis
Keyword(s):  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Phase Transitions ◽  
Fourier Transform Infrared Spectroscopy ◽  
Fourier Transform Infrared ◽  
Lipid Phase ◽  
Intact Cells ◽  
Lipid Phase Transitions

Lipid phase transitions in cat oocytes supplemented with deuterated fatty acids

2021 ◽  
Author(s):  
Konstantin A. Okotrub ◽  
Svetlana V. Okotrub ◽  
Valentina I. Mokrousova ◽  
Sergei Y. Amstislavsky ◽  
Nikolay V. Surovtsev
Keyword(s):  
Fatty Acids ◽  
Phase Transitions ◽  
Lipid Phase ◽  
Lipid Phase Transitions

Lipid phase transitions and drug interactions

1974 ◽  
Vol 363 (1) ◽  
pp. 54-69 ◽  
Author(s):  
Bryan R. Cater ◽  
Dennis Chapman ◽  
Susan M. Hawes ◽  
John Saville
Keyword(s):  
Phase Transitions ◽  
Drug Interactions ◽  
Lipid Phase ◽  
Lipid Phase Transitions
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