Ribosome protection by tRNA derivatives against inactivation by virginiamycin M: evidence for two types of interaction of tRNA with the donor site of peptidyl transferase

Biochemistry ◽  
1987 ◽  
Vol 26 (6) ◽  
pp. 1592-1597 ◽  
Author(s):  
G. Chinali ◽  
M. Di Giambattista ◽  
C. Cocito
Keyword(s):  
Donor Site ◽  
Peptidyl Transferase ◽  
Trna Derivatives

scholarly journals New photoreactive tRNA derivatives for probing the peptidyl transferase center of the ribosome

RNA ◽  
2007 ◽  
Vol 13 (5) ◽  
pp. 793-800 ◽  
Author(s):  
A. V. Manuilov ◽  
S. S. Hixson ◽  
R. A. Zimmermann
Keyword(s):  
Peptidyl Transferase ◽  
Peptidyl Transferase Center ◽  
Trna Derivatives

Improving Outcomes in Anterolateral Thigh Flap Donor-Site Reconstruction Using Propeller Flaps: A Retrospective Comparative Study with Skin Grafting

2020 ◽  
Author(s):  
Domenico Pagliara ◽  
Maria Lucia Mangialardi ◽  
Stefano Vitagliano ◽  
Valentina Pino ◽  
Marzia Salgarello
Keyword(s):  
Comparative Study ◽  
Skin Graft ◽  
Donor Site ◽  
Split Thickness Skin Graft ◽  
Tactile Sensitivity ◽  
Aesthetic Outcome ◽  
Propeller Flap ◽  
Thickness Skin ◽  
Anterolateral Thigh ◽  
Alt Flap

Abstract Background After anterolateral thigh (ALT) flap harvesting, skin graft of the donor site is commonly performed. When the defect width exceeds 8 cm or 16% of thigh circumference, it can determine lower limb function impairment and poor aesthetic outcomes. In our comparative study, we assessed the functional and aesthetic outcomes related to ALT donor-site closure with split-thickness skin graft compared with thigh propeller flap. Methods We enrolled 60 patients with ALT flap donor sites. We considered two groups of ALT donor-site reconstructions: graft group (30 patients) with split-thickness skin graft and flap group (30 patients) with local perforator-based propeller flap. We assessed for each patient the range of motion (ROM) at the hip and knee, tension, numbness, paresthesia, tactile sensitivity, and gait. Regarding the impact on daily life activities, patients completed the lower extremity functional scale (LEFS) questionnaire. Patient satisfaction for aesthetic outcome was obtained with a 5-point Likert scale (from very poor to excellent). Results In the propeller flap group, the ROMs of hip and knee and the LEFS score were significantly higher. At 12-month follow-up, in the graft group, 23 patients reported tension, 19 numbness, 16 paresthesia, 22 reduction of tactile sensitivity, and 5 alteration of gait versus only 5 patients experienced paresthesia and 7 reduction of tactile sensitivity in the propeller flap group. The satisfaction for aesthetic outcome was significantly higher in the propeller flap group. Conclusion In high-tension ALT donor-site closure, the propeller perforator flap should always be considered to avoid split-thickness skin graft with related functional and aesthetic poor results.

Versatility of the Anterolateral Thigh Donor Site in Reconstructing the United States Trauma Patient

2007 ◽  
Vol 22 (08) ◽  
Author(s):  
Eduardo Rodriguez ◽  
Gedge Rosson ◽  
Michael Grant ◽  
Navin Singh ◽  
Ronald Silverman
Keyword(s):  
United States ◽  
Trauma Patient ◽  
Donor Site ◽  
The United States ◽  
Anterolateral Thigh
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