Functional role of proteolytic cleavage at arginine-275 of human tissue plasminogen activator as assessed by site-directed mutagenesis

Keri M. Tate; Deborah L. Higgins; William E. Holmes; Marjorie E. Winkler; Herbert L. Heyneker; Gordon A. Vehar

doi:10.1021/bi00376a002

Functional role of proteolytic cleavage at arginine-275 of human tissue plasminogen activator as assessed by site-directed mutagenesis

Biochemistry ◽

10.1021/bi00376a002 ◽

1987 ◽

Vol 26 (2) ◽

pp. 338-343 ◽

Cited By ~ 106

Author(s):

Keri M. Tate ◽

Deborah L. Higgins ◽

William E. Holmes ◽

Marjorie E. Winkler ◽

Herbert L. Heyneker ◽

...

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Human Tissue ◽

Functional Role ◽

Proteolytic Cleavage ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Tissue Plasminogen

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Site-directed mutagenesis in human tissue-plasminogen activator. Distinguishing sites in the amino-terminal region required for full fibrinolytic activity and rapid clearance from the circulation.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)39394-9 ◽

1990 ◽

Vol 265 (10) ◽

pp. 5540-5545

Author(s):

T J Ahern ◽

G E Morris ◽

K M Barone ◽

P G Horgan ◽

G A Timony ◽

...

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Human Tissue ◽

Fibrinolytic Activity ◽

Terminal Region ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Amino Terminal ◽

Tissue Plasminogen ◽

Rapid Clearance

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Site-directed mutagenesis of the synthetic Erythrina trypsin / tissue plasminogen activator (tPA) inhibitor encoding-gene to compare the interaction of Erythrina and soybean trypsin inhibitor with tPA

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression ◽

10.1016/0167-4781(94)90119-8 ◽

1994 ◽

Vol 1217 (1) ◽

pp. 16-22 ◽

Cited By ~ 4

Author(s):

Avelino V. Teixeira ◽

Eugene B.D. Dowdle ◽

Dawie P. Botes

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Trypsin Inhibitor ◽

Site Directed Mutagenesis ◽

Soybean Trypsin Inhibitor ◽

Directed Mutagenesis ◽

Tissue Plasminogen ◽

Encoding Gene

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THE ROLE OF HUMAN TISSUE PLASMINOGEN ACTIVATOR IN INFLUENZA VIRUS INFECTION

Medical virology ◽

10.15610/30_2_3 ◽

2016 ◽

Vol 30 (2) ◽

Author(s):

A.A Azarenok ◽

◽

N.I. L'vov ◽

A.A Go ◽

A.R. Prochukhanova ◽

...

Keyword(s):

Influenza Virus ◽

Virus Infection ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Human Tissue ◽

Influenza Virus Infection ◽

Tissue Plasminogen

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Identification of carbohydrate structures in glycoprotein peptide maps by the use of LC/MS with selected ion extraction with special reference to tissue plasminogen activator and a glycosylation variant produced by site directed mutagenesis

Analytical Chemistry ◽

10.1021/ac00069a004 ◽

1993 ◽

Vol 65 (21) ◽

pp. 2953-2962 ◽

Cited By ~ 52

Author(s):

Andrew W. Guzzetta ◽

Louisette J. Basa ◽

William S. Hancock ◽

Bruce A. Keyt ◽

William F. Bennett

Keyword(s):

Special Reference ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Ion Extraction ◽

Tissue Plasminogen ◽

Peptide Maps

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Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)81051-7 ◽

1982 ◽

Vol 257 (6) ◽

pp. 2912-2919 ◽

Cited By ~ 7

Author(s):

M Hoylaerts ◽

D C Rijken ◽

H R Lijnen ◽

D Collen

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Human Tissue ◽

Tissue Plasminogen ◽

Kinetics Of

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Aggravation of focal cerebral ischemia by tissue-plasminogen activator is reversed by rosuvastatin - role of endothelial NO synthase

Aktuelle Neurologie ◽

10.1055/s-2004-832995 ◽

2004 ◽

Vol 31 (S 1) ◽

Author(s):

E Kilic ◽

Ü Kilic ◽

C Matter ◽

T Lüscher ◽

C Bassetti ◽

...

Keyword(s):

Cerebral Ischemia ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Focal Cerebral Ischemia ◽

No Synthase ◽

Endothelial No Synthase ◽

Tissue Plasminogen

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Novel biomimetic affinity ligands for human tissue plasminogen activator

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2007.02.007 ◽

2007 ◽

Vol 355 (3) ◽

pp. 673-678 ◽

Cited By ~ 9

Author(s):

Fang Wu ◽

Jing Yu

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Human Tissue ◽

Affinity Ligands ◽

Tissue Plasminogen

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Determination of the functional role of phenylalanine-31 of recombinant human dihydrofolate reductase by site-directed mutagenesis

Zurich, Switzerland, September 3–8, 1989 ◽

10.1515/9783110889000-148 ◽

1990 ◽

pp. 765-768

Keyword(s):

Dihydrofolate Reductase ◽

Functional Role ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Human Dihydrofolate Reductase

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Role of P225 and the C136-C201 disulfide bond in tissue plasminogen activator

Protein Science ◽

10.1002/pro.5560070807 ◽

1998 ◽

Vol 7 (8) ◽

pp. 1728-1737 ◽

Cited By ~ 13

Author(s):

Alessandro Vindigni ◽

Enrico Di Cera

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Disulfide Bond ◽

Tissue Plasminogen

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Nitrate reductase of Neurospora crassa: the functional role of individual amino acids in the heme domain as examined by site-directed mutagenesis

MGG Molecular & General Genetics ◽

10.1007/bf00277060 ◽

1993 ◽

Vol 240 (2) ◽

pp. 221-230 ◽

Cited By ~ 11

Author(s):

Patricia M. Okamoto ◽

George A. Marzluf

Keyword(s):

Amino Acids ◽

Nitrate Reductase ◽

Neurospora Crassa ◽

Functional Role ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Heme Domain

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