Binding of long-chain alkyl derivatives to lipid bilayers and to calcium-magnesium ATPase

Biochemistry ◽  
1986 ◽  
Vol 25 (23) ◽  
pp. 7535-7544 ◽  
Author(s):  
R. J. Froud ◽  
J. M. East ◽  
E. K. Rooney ◽  
A. G. Lee
Keyword(s):  
Lipid Bilayers ◽  
Alkyl Derivatives ◽  
Magnesium Atpase ◽  
Calcium Magnesium ◽  
Long Chain

Effects of lipids and long-chain alkyl derivatives on the activity of calcium-magnesium ATPase

Biochemistry ◽  
1986 ◽  
Vol 25 (23) ◽  
pp. 7544-7552 ◽  
Author(s):  
R. J. Froud ◽  
J. M. East ◽  
O. T. Jones ◽  
A. G. Lee ◽  
A. G. Lee
Keyword(s):  
Alkyl Derivatives ◽  
Magnesium Atpase ◽  
Calcium Magnesium ◽  
Long Chain

Reactivity of lysyl residues on the (calcium-magnesium)-ATPase to 7-amino-4-methylcoumarin-3-acetic acid succinimidyl ester

Biochemistry ◽  
1993 ◽  
Vol 32 (1) ◽  
pp. 356-362 ◽  
Author(s):  
H. I. Stefanova ◽  
A. M. Mata ◽  
J. M. East ◽  
M. G. Gore ◽  
A. G. Lee
Keyword(s):  
Acetic Acid ◽  
Magnesium Atpase ◽  
Calcium Magnesium ◽  
Succinimidyl Ester

Effects of phospholipids on the function of the calcium-magnesium ATPase

Biochemistry ◽  
1991 ◽  
Vol 30 (2) ◽  
pp. 342-351 ◽  
Author(s):  
F. Michelangeli ◽  
E. A. Grimes ◽  
J. M. East ◽  
A. G. Lee
Keyword(s):  
Magnesium Atpase ◽  
Calcium Magnesium

Labeling the calcium-magnesium-ATPase of sarcoplasmic reticulum at Glu-439 with 5-(bromomethyl)fluorescein

Biochemistry ◽  
1993 ◽  
Vol 32 (23) ◽  
pp. 6095-6103 ◽  
Author(s):  
H. I. Stefanova ◽  
A. M. Mata ◽  
M. G. Gore ◽  
J. M. East ◽  
A. G. Lee
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Magnesium Atpase ◽  
Calcium Magnesium

Membrane Disruption by Very Long Chain Fatty Acids During Necroptosis

2019 ◽  
Author(s):  
Laura Parisi ◽  
Shahin Sowlati-Hashjin ◽  
Ilyas Berhane ◽  
Kevin Carter ◽  
Jonathan Lovell ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cell Death ◽  
Lipid Bilayers ◽  
Membrane Permeabilization ◽  
Long Chain Fatty Acids ◽  
Fatty Acid Elongase ◽  
Fatty Acylation ◽  
Dynamics Simulations ◽  
Long Chain ◽  
Chain Fatty Acids

In this work we investigate the mechanisms by which very long chain fatty acids (VLCFA) contribute to membrane permeabilization during necroptosis, a form of highly regulated necrotic cell death. We show that inactivating fatty acid elongase ELOVL7 prevents VLCFA accumulation and necroptotic cell death, while it's overexpression causes membrane permeabilization. We show that VLCFA can directly permeabilize lipid bilayers and investigate the basis of these effects by molecular dynamics simulations. Finally, we show that VLCFA can be used as substrates for protein fatty acylation during necroptosis, suggesting another potential mechanism by which VLCFA may mediate membrane permeabilization.

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