Vesicular stomatitis virus binds and fuses with phospholipid domain in target cell membranes

Biochemistry ◽  
1986 ◽  
Vol 25 (12) ◽  
pp. 3703-3708 ◽  
Author(s):  
Satoshi Yamada ◽  
Shunichi Ohnishi
Keyword(s):  
Vesicular Stomatitis Virus ◽  
Target Cell ◽  
Cell Membranes ◽  
Vesicular Stomatitis

Neurovirulence Mutant of Vesicular Stomatitis Virus with an Altered Target Cell Tropism In Vivo

1980 ◽  
Vol 29 (2) ◽  
pp. 744-757
Author(s):  
Olivia T. Preble ◽  
Lauren E. Costello ◽  
Diana D. Huang ◽  
Mamdouha A. Barmada
Keyword(s):  
Spinal Cord ◽  
Vesicular Stomatitis Virus ◽  
Target Cell ◽  
Ependymal Cells ◽  
Temperature Sensitive ◽  
Wild Type ◽  
Neuronal Necrosis ◽  
Lateral Ventricles ◽  
Vesicular Stomatitis

Intracerebral infection of weanling Swiss mice with a temperature-sensitive ( ts ) mutant of vesicular stomatitis virus (VSV), ts pi364, resulted in a unique neuropathological syndrome not previously described with other VSV mutants. Mice infected with wild-type VSV died from an acute encephalitis characterized by neuronal necrosis and efficient virus replication in both brain and spinal cord. In contrast, with VSV ts pi364, the most prominent histopathological feature was destruction of the ependyma of the lateral ventricles. Virus antigen was also limited to the leptomeninges and the lateral ventricles. Infected mice survived and developed hydrocephalus. Replication of ts pi364 in the brain was 10- to 100- fold less than that of wild-type VSV, and appearance of virus in the spinal cord was delayed. VSV ts pi364 was isolated from mouse cells persistently infected with VSV. Another VSV ts pi mutant, isolated from the same persistent infection, behaved in vivo like wild-type VSV, even though both mutants were very similar in plaque size, reversion frequency, cut-off temperature, and synthesis of virus-specific proteins at semipermissive temperature. These results strongly suggest that VSV ts pi364 has a second, non- ts mutation which results in a restricted target cell range in vivo; wild-type VSV can infect both neurons and ependymal cells, whereas ts pi364 does not replicate in neurons.

626: Initial Experience with Vesicular Stomatitis Virus as a Treatment for Bladder Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 202-202
Author(s):  
Sherwin Zargaroff ◽  
Yuancheng Wang ◽  
Xiayong Zheng ◽  
Jian Pu ◽  
Savio L. Woo ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Vesicular Stomatitis Virus ◽  
Initial Experience ◽  
Vesicular Stomatitis

Inhibition of Various Steps in the Replication Cycle of Vesicular Stomatitis Virus Contributes to Its Photoinactivation by AlPcS4 or Pc4 and Red Light

1999 ◽  
Vol 69 (3) ◽  
pp. 353 ◽  
Author(s):  
Anne C. E. Moor ◽  
Angeline E. Wagenaars-van Gompel ◽  
Ralph C. A. Hermanns ◽  
Jannes van der Meulen ◽  
Jolanda Smit ◽  
...  
Keyword(s):  
Vesicular Stomatitis Virus ◽  
Red Light ◽  
Replication Cycle ◽  
Vesicular Stomatitis
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