Human brain monoamine oxidase type B: mechanism of deamination as probed by steady-state methods

Biochemistry ◽  
1985 ◽  
Vol 24 (8) ◽  
pp. 1821-1826 ◽  
Author(s):  
L. Bruce Pearce ◽  
Jerome A. Roth
Keyword(s):  
Steady State ◽  
Monoamine Oxidase ◽  
Human Brain ◽  
Type B ◽  
Brain Monoamine ◽  
Monoamine Oxidase Type B

[3H]Ro 16?6491, a Selective Probe for Affinity Labelling of Monoamine Oxidase Type B in Human Brain and Platelet Membranes

1988 ◽  
Vol 50 (4) ◽  
pp. 1037-1043 ◽  
Author(s):  
A. M. Cesura ◽  
R. Imhof ◽  
B. Takacs ◽  
M. D. Galva ◽  
G. B. Picotti ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Human Brain ◽  
Type B ◽  
Platelet Membranes ◽  
Affinity Labelling ◽  
Monoamine Oxidase Type B

scholarly journals Comparative effectiveness of dopamine agonists and monoamine oxidase type-B inhibitors for Parkinson’s disease: a multiple treatment comparison meta-analysis

2020 ◽  
Vol 76 (12) ◽  
pp. 1731-1743
Author(s):  
Caroline D. Binde ◽  
Ingunn F. Tvete ◽  
Jørund I. Gåsemyr ◽  
Bent Natvig ◽  
Marianne Klemp
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Monoamine Oxidase ◽  
Comparative Effectiveness ◽  
Dopamine Agonists ◽  
Relative Effectiveness ◽  
Type B ◽  
Mao B ◽  
Treatment Comparison ◽  
Monoamine Oxidase Type B

Abstract Purpose To investigate the comparative effectiveness of dopamine agonists and monoamine oxidase type-B (MAO-B) inhibitors available for treatment of Parkinson’s disease. Methods We performed a systematic literature search identifying randomized controlled trials investigating 4 dopamine agonists (cabergoline, pramipexole, ropinirole, rotigotine) and 3 MAO-B inhibitors (selegiline, rasagiline, safinamide) for Parkinson’s disease. We extracted and pooled data from included clinical trials in a joint model allowing both direct and indirect comparison of the seven drugs. We considered dopamine agonists and MAO-B inhibitors given as monotherapy or in combination with levodopa. Selected endpoints were change in the Unified Parkinson’s Disease Rating Scale (UPDRS) score, serious adverse events and withdrawals. We estimated the relative effectiveness of each dopamine agonist and MAO-B inhibitor versus comparator drug. Results Altogether, 79 publications were included in the analysis. We found all the investigated drugs to be effective compared with placebo when given as monotherapy except safinamide. When considering combination treatment, the estimated relative effects of selegiline, pramipexole, ropinirole, rotigotine, cabergoline, rasagiline and safinamide were 2.316 (1.819, 2.951), 2.091 (1.889, 2.317), 2.037 (1.804, 2.294), 1.912 (1.716, 2.129), 1.664 (1.113, 2.418), 1.584 (1.379, 1.820) and 1.179 (1.031, 1.352), respectively, compared with joint placebo and levodopa treatment. Conclusions Dopamine agonists were found to be effective as treatment for Parkinson’s disease, both when given as monotherapy and in combination with levodopa. Selegiline and rasagiline were also found to be effective for treating Parkinson’s disease, and selegiline was the best option in combination with levodopa among all the drugs investigated.

Titration of human brain monoamine oxidase-A and-B by clorgyline andl-deprenil

1980 ◽  
Vol 311 (3) ◽  
pp. 263-272 ◽  
Author(s):  
Christopher J. Fowler ◽  
Lars Oreland ◽  
Jan Marcusson ◽  
Bengt Winblad
Keyword(s):  
Monoamine Oxidase ◽  
Human Brain ◽  
Monoamine Oxidase A ◽  
Brain Monoamine
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