Microsomal hydroxylation of specifically deuterated monosubstituted benzenes. Evidence for direct aromatic hydroxylation

Biochemistry ◽  
1984 ◽  
Vol 23 (13) ◽  
pp. 3048-3055 ◽  
Author(s):  
Robert P. Hanzlik ◽  
Kerstin Hogberg ◽  
Charles M. Judson
Keyword(s):  
Aromatic Hydroxylation ◽  
Monosubstituted Benzenes ◽  
Microsomal Hydroxylation

scholarly journals Contribution of cytochromes and proteins to the effect of ascorbic acid on artificial and microsomal hydroxylation systems containing oxygen and hydrogen peroxide

1978 ◽  
Vol 170 (3) ◽  
pp. 693-698 ◽  
Author(s):  
J Chrastil ◽  
J T Wilson
Keyword(s):  
Hydrogen Peroxide ◽  
Ascorbic Acid ◽  
Free Radical ◽  
Cytochrome C ◽  
Rat Liver ◽  
Oxidative Demethylation ◽  
Aromatic Hydroxylation ◽  
Microsomal Hydroxylation ◽  
Cytochrome P 450

Hydroxylation systems containing cytochromes, proteins and ascorbic acid were studied at physiological pH (7.4) under O2 or N2 with added H2O2. Proteins inhibited aromatic hydroxylation of p-nitrophenol or oxidative demethylation of ethylmorphine in ascorbic acid-containing systems incubated under O2, but strongly activated the systems containing H2O2. Cytochrome c and partially purified cytochrome P-450 from rat liver microsomal preparations activated the system in either O2 or H2O2. The systems needed ascorbic acid (or other enol structures) for activation. Cytochrome iron participated probably in the activation of O2, whereas cytochrome protein participated in a free radical activation of H2O2 (or of O2).

Unmasking Steps in Intramolecular Aromatic Hydroxylation by a Synthetic Nonheme Oxoiron(IV) Complex

2021 ◽  
Author(s):  
Lawrence Que ◽  
Yuan Sheng ◽  
Chase S. Abelson ◽  
Jai Prakash ◽  
Apparao Draksharapu ◽  
...  
Keyword(s):  
Aromatic Hydroxylation

Nuclear Magnetic Resonance Chemical Shifts of some Monosubstituted Isothiazoles

1975 ◽  
Vol 53 (4) ◽  
pp. 596-603 ◽  
Author(s):  
Roderick E. Wasylishen ◽  
Thomas R. Clem ◽  
Edwin D. Becker
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Chemical Shifts ◽  
Substituent Effects ◽  
Charge Densities ◽  
Monosubstituted Benzenes ◽  
Proton Chemical Shifts ◽  
Nuclear Magnetic

Carbon-13 and proton chemical shifts have been measured for several monosubstituted isothiazoles. Substituent effects upon these chemical shifts are compared with those observed for monosubstituted benzenes, pyridines, and thiophenes. In general the observed substituent effects in the isothiazoles and thiophenes closely parallel one another. Correlations between the observed carbon-13 Chemical shifts and CNDO/2 calculated charge densities are examined.

Chemoenzymatic synthesis of the trans-dihydrodiol isomers of monosubstituted benzenes viaanti-benzene dioxides

2006 ◽  
Vol 4 (11) ◽  
pp. 2208 ◽  
Author(s):  
Derek R. Boyd ◽  
Narain D. Sharma ◽  
Nuria M. Llamas ◽  
Colin R. O'Dowd ◽  
Christopher C. R. Allen
Keyword(s):  
Chemoenzymatic Synthesis ◽  
Monosubstituted Benzenes

scholarly journals Aromatic Hydroxylation of Indan by o-Xylene-Degrading Rhodococcus sp. Strain DK17

2009 ◽  
Vol 76 (1) ◽  
pp. 375-377 ◽  
Author(s):  
Dockyu Kim ◽  
Choong Hwan Lee ◽  
Jung Nam Choi ◽  
Ki Young Choi ◽  
Gerben J. Zylstra ◽  
...  
Keyword(s):  
Reverse Transcription ◽  
Ring Cleavage ◽  
Growth Substrate ◽  
Aromatic Moiety ◽  
Reverse Transcription Pcr ◽  
Aromatic Hydroxylation ◽  
Rhodococcus Sp

ABSTRACT The metabolically versatile Rhodococcus sp. strain DK17 utilizes indan as a growth substrate via the o-xylene pathway. Metabolite and reverse transcription-PCR analyses indicate that o-xylene dioxygenase hydroxylates indan at the 4,5 position of the aromatic moiety to form cis-indan-4,5-dihydrodiol, which is dehydrogenated to 4,5-indandiol by a dehydrogenase. 4,5-Indandiol undergoes ring cleavage by a meta-cleavage dioxygenase.

Mechanistic Insight into the Aromatic Hydroxylation by High-Valent Iron(IV)-oxo Porphyrin π-Cation Radical Complexes

2007 ◽  
Vol 72 (16) ◽  
pp. 6301-6304 ◽  
Author(s):  
Min-Jung Kang ◽  
Woon Ju Song ◽  
Ah-Rim Han ◽  
Young S. Choi ◽  
Ho G. Jang ◽  
...  
Keyword(s):  
Cation Radical ◽  
Mechanistic Insight ◽  
Aromatic Hydroxylation ◽  
High Valent ◽  
Insight Into
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