Nature of steady-state and newly synthesized mitochondrial messenger ribonucleic acids in mouse liver and Ehrlich ascites tumor cells

Biochemistry ◽  
1984 ◽  
Vol 23 (8) ◽  
pp. 1695-1701 ◽  
Author(s):  
Kolari S. Bhat ◽  
Gouder R. Kantharaj ◽  
Narayan G. Avadhani
Keyword(s):  
Steady State ◽  
Tumor Cells ◽  
Mouse Liver ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Ribonucleic Acids ◽  
Ehrlich Ascites

scholarly journals One-way fluxes of alpha-aminoisobutyric acid in Ehrlich ascites tumor cells. Trans effects and effects of sodium and potassium.

1975 ◽  
Vol 65 (1) ◽  
pp. 57-83 ◽  
Author(s):  
J A Jacquez
Keyword(s):  
Steady State ◽  
Tumor Cells ◽  
Nonlinear Least Squares ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Aminoisobutyric Acid ◽  
Carrier Model ◽  
Ehrlich Ascites ◽  
The One

One-way fluxes in the steady state and one-way influxes at zero intracellular concentrations were measured for alpha-aminoisobutyric acid (AIB) in Ehrlich ascites tumor cells at 32 degrees C. The one-way fulxes show trans effects in the concentration of AIB and are dependent on sodium levels. The one-way fluxes for initial influx and for the steady state were fitted with the equations derived for the frequently used two-state carrier model. Estimates of the parameters of these equations were obtained with use of nonlinear least squares. These gave relatively good fits of the flux data and the data on steady-state distribution ratios. The two-state carrier model predicted a trans inhibition of one-way influx and a trans stimulation of one-way efflux. The former phenomenon has been demonstrated for AIB transport in Ehrlich ascites cells and there is evidence, through less firm, for the latter.

Ultrastructural characterization of the effects of beta-alanyl-melphalan in mouse Ehrlich ascites tumor cells and mouse liver cells

1992 ◽  
Vol 50 (1) ◽  
pp. 642-643
Author(s):  
Michael Adam ◽  
Bao-Ling Tsay Adam ◽  
Lloyd Wolfinbarger
Keyword(s):  
Tumor Cells ◽  
Mouse Liver ◽  
Cell Damage ◽  
Liver Cells ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Ehrlich Ascites ◽  
Marked Cell

Beta-alanyl-melphalan (BAM) was demonstrated to have significant cancerocidal activity using both in vitro cultures and in vivo chemotherapy assays. Ultrastructural observations in the present study confirmed the antitumor activity of melphalan (MEL) and BAM. Results showed that the MEL affected the cellular elements causing marked cell damage both in mouse Ehrlich ascites tumor cells (MEATC) and mouse liver cells (MLC). BAM appeared to affect the cellular elements, with marked cell damage, only in MEATC, but not in the MLC. There were nuclear and cytoplasmic alterations in MEL and BAM treated MEATC, i.e. peripheral thickening of chromatin in nuclei, severe mitochondrial alterations, ribosome accumulation and autolysis phenomena which lead to the destruction of the subcellular structures.

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