Structural and Functional Characterization of Second-Coordination Sphere Mutants of Soybean Lipoxygenase-1†

Biochemistry ◽  
2001 ◽  
Vol 40 (25) ◽  
pp. 7509-7517 ◽  
Author(s):  
Diana R. Tomchick ◽  
Phuc Phan ◽  
Marcin Cymborowski ◽  
Wladek Minor ◽  
Theodore R. Holman
Keyword(s):  
Coordination Sphere ◽  
Functional Characterization ◽  
Soybean Lipoxygenase ◽  
Second Coordination Sphere

scholarly journals Characterization of a bacterial copper‐dependent lytic polysaccharide monooxygenase with an unusual second coordination sphere

FEBS Journal ◽  
2020 ◽  
Vol 287 (15) ◽  
pp. 3298-3314 ◽  
Author(s):  
Alessia Munzone ◽  
Bilal El Kerdi ◽  
Mathieu Fanuel ◽  
Hélène Rogniaux ◽  
David Ropartz ◽  
...  
Keyword(s):  
Coordination Sphere ◽  
Lytic Polysaccharide Monooxygenase ◽  
Second Coordination Sphere ◽  
Polysaccharide Monooxygenase

Synthesis and characterization of FeIII(μ-OH)ZnII complexes: effects of a second coordination sphere and increase in the chelate ring size on the hydrolysis of a phosphate diester and DNA

2017 ◽  
Vol 46 (34) ◽  
pp. 11380-11394 ◽  
Author(s):  
Graciela Aparecida dos Santos Silva ◽  
André Luiz Amorim ◽  
Bernardo de Souza ◽  
Philipe Gabriel ◽  
Hernán Terenzi ◽  
...  
Keyword(s):  
Coordination Sphere ◽  
Chelate Ring ◽  
Synthesis And Characterization ◽  
Ring Size ◽  
Phosphate Diester ◽  
Second Coordination Sphere ◽  
Hydrolysis Of ◽  
Chelate Ring Size

Effects of a second coordination sphere and of the chelate ring size in FeIII(μ-OH)ZnII complexes properties and catalysis.

Functional characterization of human brown adipose tissue metabolism

2020 ◽  
Vol 477 (7) ◽  
pp. 1261-1286 ◽  
Author(s):  
Marie Anne Richard ◽  
Hannah Pallubinsky ◽  
Denis P. Blondin
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Functional Characterization ◽  
Human Infants ◽  
Positron Emission ◽  
Brown Adipose ◽  
Treatment Of Obesity ◽  
And Function

Brown adipose tissue (BAT) has long been described according to its histological features as a multilocular, lipid-containing tissue, light brown in color, that is also responsive to the cold and found especially in hibernating mammals and human infants. Its presence in both hibernators and human infants, combined with its function as a heat-generating organ, raised many questions about its role in humans. Early characterizations of the tissue in humans focused on its progressive atrophy with age and its apparent importance for cold-exposed workers. However, the use of positron emission tomography (PET) with the glucose tracer [18F]fluorodeoxyglucose ([18F]FDG) made it possible to begin characterizing the possible function of BAT in adult humans, and whether it could play a role in the prevention or treatment of obesity and type 2 diabetes (T2D). This review focuses on the in vivo functional characterization of human BAT, the methodological approaches applied to examine these features and addresses critical gaps that remain in moving the field forward. Specifically, we describe the anatomical and biomolecular features of human BAT, the modalities and applications of non-invasive tools such as PET and magnetic resonance imaging coupled with spectroscopy (MRI/MRS) to study BAT morphology and function in vivo, and finally describe the functional characteristics of human BAT that have only been possible through the development and application of such tools.

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