Asymmetric Structure of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore Suggested by Mutagenesis of the Twelfth Transmembrane Region†

Jyoti Gupta; Alexandra Evagelidis; John W. Hanrahan; Paul Linsdell

doi:10.1021/bi002819v

Asymmetric Structure of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore Suggested by Mutagenesis of the Twelfth Transmembrane Region†

Biochemistry ◽

10.1021/bi002819v ◽

2001 ◽

Vol 40 (22) ◽

pp. 6620-6627 ◽

Cited By ~ 31

Author(s):

Jyoti Gupta ◽

Alexandra Evagelidis ◽

John W. Hanrahan ◽

Paul Linsdell

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Asymmetric Structure ◽

Transmembrane Conductance Regulator ◽

Transmembrane Region ◽

Transmembrane Conductance ◽

Channel Pore ◽

Cystic Fibrosis Transmembrane

Download Full-text

Molecular Determinants of Anion Selectivity in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore

Biophysical Journal ◽

10.1016/s0006-3495(00)76836-6 ◽

2000 ◽

Vol 78 (6) ◽

pp. 2973-2982 ◽

Cited By ~ 69

Author(s):

Paul Linsdell ◽

Alexandra Evagelidis ◽

John W. Hanrahan

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Channel Pore ◽

Anion Selectivity ◽

Molecular Determinants ◽

Cystic Fibrosis Transmembrane

Download Full-text

Relationship between anion binding and anion permeability revealed by mutagenesis within the cystic fibrosis transmembrane conductance regulator chloride channel pore

The Journal of Physiology ◽

10.1111/j.1469-7793.2001.0051j.x ◽

2001 ◽

Vol 531 (1) ◽

pp. 51-66 ◽

Cited By ~ 61

Author(s):

Paul Linsdell

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Anion Binding ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Channel Pore ◽

Anion Permeability ◽

Cystic Fibrosis Transmembrane

Download Full-text

Direct Comparison of the Functional Roles Played by Different Transmembrane Regions in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore

Journal of Biological Chemistry ◽

10.1074/jbc.m411935200 ◽

2004 ◽

Vol 279 (53) ◽

pp. 55283-55289 ◽

Cited By ~ 50

Author(s):

Ning Ge ◽

Chantal N. Muise ◽

Xiandi Gong ◽

Paul Linsdell

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Channel Pore ◽

Functional Roles ◽

Transmembrane Regions ◽

Cystic Fibrosis Transmembrane

Download Full-text

Identification of a Second Blocker Binding Site at the Cytoplasmic Mouth of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore

Molecular Pharmacology ◽

10.1124/mol.106.031732 ◽

2007 ◽

Vol 71 (5) ◽

pp. 1360-1368 ◽

Cited By ~ 30

Author(s):

Chantal N. St. Aubin ◽

Jing-Jun Zhou ◽

Paul Linsdell

Keyword(s):

Cystic Fibrosis ◽

Binding Site ◽

Chloride Channel ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Channel Pore ◽

Cystic Fibrosis Transmembrane

Download Full-text

Functional organization of cytoplasmic portals controlling access to the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel pore

Journal of Biological Chemistry ◽

10.1074/jbc.ra117.001373 ◽

2018 ◽

Vol 293 (15) ◽

pp. 5649-5658 ◽

Cited By ~ 8

Author(s):

Man-Song Li ◽

Elizabeth A. Cowley ◽

Yassine El Hiani ◽

Paul Linsdell

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Functional Organization ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Channel Pore ◽

Cystic Fibrosis Transmembrane

Download Full-text

Interactions between Impermeant Blocking Ions in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore: Evidence for Anion-Induced Conformational Changes

The Journal of Membrane Biology ◽

10.1007/s00232-005-7028-2 ◽

2006 ◽

Vol 210 (1) ◽

pp. 31-42 ◽

Cited By ~ 7

Author(s):

Ning Ge ◽

Paul Linsdell

Keyword(s):

Cystic Fibrosis ◽

Conformational Changes ◽

Chloride Channel ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Channel Pore ◽

Cystic Fibrosis Transmembrane

Download Full-text

Functional Architecture of the Cytoplasmic Entrance to the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore

Journal of Biological Chemistry ◽

10.1074/jbc.m115.656181 ◽

2015 ◽

Vol 290 (25) ◽

pp. 15855-15865 ◽

Cited By ~ 22

Author(s):

Yassine El Hiani ◽

Paul Linsdell

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Functional Architecture ◽

Channel Pore ◽

Cystic Fibrosis Transmembrane

Download Full-text

Location of a permeant anion binding site in the cystic fibrosis transmembrane conductance regulator chloride channel pore

The Journal of Physiological Sciences ◽

10.1007/s12576-015-0359-6 ◽

2015 ◽

Vol 65 (3) ◽

pp. 233-241 ◽

Cited By ~ 10

Author(s):

Hussein N. Rubaiy ◽

Paul Linsdell

Keyword(s):

Cystic Fibrosis ◽

Binding Site ◽

Chloride Channel ◽

Anion Binding ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Channel Pore ◽

Cystic Fibrosis Transmembrane ◽

Permeant Anion

Download Full-text

Direct and Indirect Effects of Mutations at the Outer Mouth of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore

The Journal of Membrane Biology ◽

10.1007/s00232-007-9056-6 ◽

2007 ◽

Vol 216 (2-3) ◽

pp. 129-142 ◽

Cited By ~ 21

Author(s):

Jing-Jun Zhou ◽

Mohammad Fatehi ◽

Paul Linsdell

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Indirect Effects ◽

Transmembrane Conductance Regulator ◽

Direct And Indirect Effects ◽

Transmembrane Conductance ◽

Channel Pore ◽

Cystic Fibrosis Transmembrane

Download Full-text

State-dependent Access of Anions to the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore

Journal of Biological Chemistry ◽

10.1074/jbc.m707736200 ◽

2007 ◽

Vol 283 (10) ◽

pp. 6102-6109 ◽

Cited By ~ 22

Author(s):

Mohammad Fatehi ◽

Paul Linsdell

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Channel Pore ◽

State Dependent ◽

Cystic Fibrosis Transmembrane

Download Full-text