Light-chain phosphorylation and cross-bridge conformation in myosin from vertebrate skeletal muscle

Biochemistry ◽  
1983 ◽  
Vol 22 (3) ◽  
pp. 525-530 ◽  
Author(s):  
Ana Mrakovcic-Zenic ◽  
Emil Reisler
Keyword(s):  
Skeletal Muscle ◽  
Light Chain ◽  
Cross Bridge ◽  
Vertebrate Skeletal Muscle

scholarly journals Myosin molecule packing within the vertebrate skeletal muscle thick filaments. A complete bipolar model.

2002 ◽  
Vol 49 (4) ◽  
pp. 829-840 ◽  
Author(s):  
Ludmila Skubiszak ◽  
Leszek Kowalczyk
Keyword(s):  
Skeletal Muscle ◽  
Computer Modelling ◽  
Thick Filament ◽  
Myosin Molecule ◽  
Bipolar Structure ◽  
Cross Bridge ◽  
Filament Axis ◽  
Thick Filaments ◽  
C Terminus ◽  
Vertebrate Skeletal Muscle

Computer modelling related to the real dimensions of both the whole filament and the myosin molecule subfragments has revealed two alternative modes for myosin molecule packing which lead to the head disposition similar to that observed by EM on the surface of the cross-bridge zone of the relaxed vertebrate skeletal muscle thick filaments. One of the modes has been known for three decades and is usually incorporated into the so-called three-stranded model. The new mode differs from the former one in two aspects: (1) myosin heads are grouped into asymmetrical cross-bridge crowns instead of symmetrical ones; (2) not the whole myosin tail, but only a 43-nm C-terminus of each of them is straightened and near-parallel to the filament axis, the rest of the tail is twisted. Concurrent exploration of these alternative modes has revealed their influence on the filament features. The parameter values for the filament models as well as for the building units depicting the myosin molecule subfragments are verified by experimental data found in the literature. On the basis of the new mode for myosin molecule packing a complete bipolar structure of the thick filament is created.

scholarly journals The molecular basis for sarcomere organization in vertebrate skeletal muscle

Cell ◽  
2021 ◽  
Vol 184 (8) ◽  
pp. 2135-2150.e13
Author(s):  
Zhexin Wang ◽  
Michael Grange ◽  
Thorsten Wagner ◽  
Ay Lin Kho ◽  
Mathias Gautel ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Molecular Basis ◽  
Vertebrate Skeletal Muscle
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