Properties of conserved amino acid residues in tandem homologous protein domains. Proton NMR studies of the histidines of chicken ovomucoid

Biochemistry ◽  
1982 ◽  
Vol 21 (14) ◽  
pp. 3452-3460 ◽  
Author(s):  
Takashi Ogino ◽  
David H. Croll ◽  
Ikunoshin Kato ◽  
John L. Markley
Keyword(s):  
Amino Acid ◽  
Proton Nmr ◽  
Protein Domains ◽  
Amino Acid Residues ◽  
Nmr Studies ◽  
Homologous Protein

Critical protein domains and amino acid residues for gating the KIR6.2 channel by intracellular ATP

2003 ◽  
Vol 198 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Jianping Wu ◽  
Hailan Piao ◽  
Asheebo Rojas ◽  
Runping Wang ◽  
Ying Wang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Protein Domains ◽  
Amino Acid Residues ◽  
Intracellular Atp

УРОВНИ ИЕРАРХИЧЕСКОЙ ОРГАНИЗАЦИИ БЕЛКОВЫХ ПОСЛЕДОВАТЕЛЬНОСТЕЙ. АНАЛИЗ ЭНТРОПИЙНЫХ ХАРАКТЕРИСТИК

2020 ◽  
Vol 65 (6) ◽  
pp. 1065-1071
Author(s):  
А.Н. Некрасов ◽  
◽  
Ю.П. Козмин ◽  
С.В. Козырев ◽  
Н.Г. Есипова ◽  
...  
Keyword(s):  
Mathematical Method ◽  
Amino Acid ◽  
Secondary Structure ◽  
Protein Sequences ◽  
Amino Acid Residues ◽  
Homologous Protein ◽  
Levels Of Organization

This research investigates 24 647 non-homologous protein sequences. The occurrence profile of peptapeptides was constructed for every sequence and hierarchically organized elements of various sizes were revealed by a special mathematical method in each profile. The correlations between these hierarchical elements were analyzed and it was shown that in a tested set of protein sequences there are 11 levels of protein organization with elements ranging in length from 7 to 56 amino acid residues. It was suggested that the identified levels of organization correspond to elements of a super-secondary structure with different topology.

Spin-labeling proton NMR study on aromatic amino acid residues in the guanine nucleotide binding site of human c-Ha-ras(1-171) protein

Biochemistry ◽  
1989 ◽  
Vol 28 (24) ◽  
pp. 9550-9556 ◽  
Author(s):  
Akiko Hata-Tanaka ◽  
Gota Kawai ◽  
Kazuhiko Yamasaki ◽  
Yutaka Ito ◽  
Hiroko Kajiura ◽  
...  
Keyword(s):  
Amino Acid ◽  
Binding Site ◽  
Aromatic Amino Acid ◽  
Proton Nmr ◽  
Nucleotide Binding ◽  
Spin Labeling ◽  
Guanine Nucleotide ◽  
Amino Acid Residues ◽  
Nmr Study ◽  
Guanine Nucleotide Binding

RPMS: Ramachandran plot for multiple structures

2008 ◽  
Vol 41 (1) ◽  
pp. 219-221 ◽  
Author(s):  
K. Gopalakrishnan ◽  
S. Saravanan ◽  
R. Sarani ◽  
K. Sekar
Keyword(s):  
Amino Acid ◽  
Protein Structures ◽  
Data Bank ◽  
Amino Acid Residues ◽  
Ramachandran Plot ◽  
Homologous Protein ◽  
Internet Computing ◽  
Multiple Structures ◽  
Atomic Coordinates ◽  
Local Machine

An interactive internet computing server,RPMS(Ramachandran plot for multiple structures) has been developed to visualize the Ramachandran angles of several highly homologous protein structures in a single plot. Options are provided for users to locate the amino acid residues in various regions of the plot. To perform the above, users need to enter the Protein Data Bank (PDB) identification codes. In addition, users can upload the atomic coordinates from the local machine. A Java graphics interface has been deployed and the server has been interfaced with a locally maintained PDB anonymous FTP server, which is updated weekly. The serverRPMScan be accessed through the Bioinformatics web server at http://cluster.physics.iisc.ernet.in/rpms/.

scholarly journals Roseabol A, a New Peptaibol from the Fungus Clonostachys rosea

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3594
Author(s):  
Chang-Kwon Kim ◽  
Lauren R. H. Krumpe ◽  
Emily Smith ◽  
Curtis J. Henrich ◽  
Isaac Brownell ◽  
...  
Keyword(s):  
Amino Acid ◽  
Octadecenoic Acid ◽  
Isovaleric Acid ◽  
Tandem Ms ◽  
Amino Acid Residues ◽  
Acid Moiety ◽  
Clonostachys Rosea ◽  
Nmr Studies ◽  
Linear Peptide ◽  
Ic50 Value

A new 11 amino acid linear peptide named roseabol A (1) and the known compound 13-oxo-trans-9,10-epoxy-11(E)-octadecenoic acid (2) were isolated from the fungus Clonostachys rosea. Combined NMR and MS analysis revealed that roseabol A (1) contained amino acid residues characteristic of the peptaibol family of peptides such as isovaline, α-aminoisobutyric acid, hydroxyproline, leucinol, and an N-terminal isovaleric acid moiety. The amino acid sequence was established by a combination of NMR studies and tandem MS fragmentation analyses, and the absolute configurations of the constituent amino acids of 1 were determined by the advanced Marfey’s method. Compound 2 showed inhibitory activity against Merkel cell carcinoma, a rare and difficult-to-treat type of skin cancer, with an IC50 value of 16.5 μM.

Sign in / Sign up

Export Citation Format

Share Document