Binding sites for .alpha.-bungarotoxin and the noncompetitive inhibitor phencyclidine on a synthetic peptide comprising residues 172-227 of the .alpha.-subunit of the nicotinic acetylcholine receptor

Diana L. Donnelly-Roberts; Thomas L. Lentz

doi:10.1021/bi00244a017

Binding sites for .alpha.-bungarotoxin and the noncompetitive inhibitor phencyclidine on a synthetic peptide comprising residues 172-227 of the .alpha.-subunit of the nicotinic acetylcholine receptor

Biochemistry ◽

10.1021/bi00244a017 ◽

1991 ◽

Vol 30 (30) ◽

pp. 7484-7491 ◽

Cited By ~ 13

Author(s):

Diana L. Donnelly-Roberts ◽

Thomas L. Lentz

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Sites ◽

Synthetic Peptide ◽

Alpha Subunit ◽

Nicotinic Acetylcholine ◽

Noncompetitive Inhibitor ◽

Alpha Bungarotoxin

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Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)38551-5 ◽

1990 ◽

Vol 265 (19) ◽

pp. 11017-11029 ◽

Cited By ~ 1

Author(s):

M DiPaola ◽

P N Kao ◽

A Karlin

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Active State ◽

Alpha Subunit ◽

Nicotinic Acetylcholine ◽

Noncompetitive Inhibitor

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Structural determinants of .alpha.-bungarotoxin binding to the sequence segment 181-200 of the muscle nicotinic acetylcholine receptor .alpha. subunit: effects of cysteine/cystine modification and species-specific amino acid substitutions

Biochemistry ◽

10.1021/bi00234a013 ◽

1991 ◽

Vol 30 (20) ◽

pp. 4925-4934 ◽

Cited By ~ 35

Author(s):

Kathryn E. McLane ◽

Xiadong Wu ◽

Brenda Diethelm ◽

Bianca M. Conti-Tronconi

Keyword(s):

Amino Acid ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Alpha Subunit ◽

Amino Acid Substitutions ◽

Structural Determinants ◽

Nicotinic Acetylcholine ◽

Specific Amino Acid ◽

Species Specific ◽

Alpha Bungarotoxin

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Location of ligand-binding sites on the nicotinic acetylcholine receptor alpha-subunit.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)67082-6 ◽

1986 ◽

Vol 261 (29) ◽

pp. 13735-13743 ◽

Cited By ~ 10

Author(s):

S E Pedersen ◽

E B Dreyer ◽

J B Cohen

Keyword(s):

Ligand Binding ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Sites ◽

Alpha Subunit ◽

Nicotinic Acetylcholine ◽

Receptor Alpha ◽

Ligand Binding Sites

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Identification of sequence segments forming the alpha-bungarotoxin binding sites on two nicotinic acetylcholine receptor alpha subunits from the avian brain

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)98607-2 ◽

1991 ◽

Vol 266 (23) ◽

pp. 15230-15239

Author(s):

K.E. McLane ◽

X.D. Wu ◽

R. Schoepfer ◽

J.M. Lindstrom ◽

B.M. Conti-Tronconi

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Sites ◽

Avian Brain ◽

Nicotinic Acetylcholine ◽

Receptor Alpha ◽

Alpha Subunits ◽

Alpha Bungarotoxin

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Interaction of monoclonal antibodies with alpha-bungarotoxin and (-)-nicotine binding sites in goldfish brain. Identification of putative nicotinic acetylcholine receptor subtypes.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)81572-7 ◽

1988 ◽

Vol 263 (20) ◽

pp. 9686-9691

Author(s):

J M Henley ◽

J M Lindstrom ◽

R E Oswald

Keyword(s):

Monoclonal Antibodies ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Sites ◽

Receptor Subtypes ◽

Nicotinic Acetylcholine ◽

Alpha Bungarotoxin

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An .alpha.-Bungarotoxin-Binding Sequence on the Torpedo Nicotinic Acetylcholine Receptor .alpha.-Subunit: Conservative Amino Acid Substitutions Reveal Side-Chain Specific Interactions

Biochemistry ◽

10.1021/bi00175a029 ◽

1994 ◽

Vol 33 (9) ◽

pp. 2576-2585 ◽

Cited By ~ 13

Author(s):

Kathryn E. McLane ◽

Xiadong Wu ◽

Bianca M. Conti-Tronconi

Keyword(s):

Amino Acid ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Alpha Subunit ◽

Side Chain ◽

Amino Acid Substitutions ◽

Specific Interactions ◽

Nicotinic Acetylcholine ◽

Alpha Bungarotoxin ◽

Binding Sequence

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Faculty Opinions recommendation of Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5804956.5786054 ◽

2010 ◽

Author(s):

Edward Bertaccini

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Sites ◽

Transmembrane Domain ◽

General Anesthetic ◽

Nicotinic Acetylcholine ◽

Multiple Binding Sites ◽

Multiple Binding

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Expression of the alpha-bungarotoxin binding site of the nicotinic acetylcholine receptor by Escherichia coli transformants.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.84.12.4318 ◽

1987 ◽

Vol 84 (12) ◽

pp. 4318-4321 ◽

Cited By ~ 44

Author(s):

J. M. Gershoni

Keyword(s):

Escherichia Coli ◽

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Alpha Bungarotoxin

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Antipeptide monoclonal antibodies inhibit the binding of rabies virus glycoprotein and alpha-bungarotoxin to the nicotinic acetylcholine receptor

Molecular Immunology ◽

10.1016/0161-5890(88)90125-3 ◽

1988 ◽

Vol 25 (9) ◽

pp. 881-888 ◽

Cited By ~ 32

Author(s):

Luisa Bracci ◽

Guido Antoni ◽

Maria Grazia Cusi ◽

Luisa Lozzi ◽

Neri Niccolai ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Rabies Virus ◽

Nicotinic Acetylcholine ◽

Rabies Virus Glycoprotein ◽

Virus Glycoprotein ◽

Alpha Bungarotoxin

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Sequence and functional expression of a single alpha subunit of an insect nicotinic acetylcholine receptor.

The EMBO Journal ◽

10.1002/j.1460-2075.1990.tb07889.x ◽

1990 ◽

Vol 9 (13) ◽

pp. 4391-4398 ◽

Cited By ~ 105

Author(s):

J. Marshall ◽

S. D. Buckingham ◽

R. Shingai ◽

G. G. Lunt ◽

M. W. Goosey ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Functional Expression ◽

Alpha Subunit ◽

Nicotinic Acetylcholine

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