ENDOR Structural Characterization of a Catalytically Competent Acylenzyme Reaction Intermediate of Wild-Type TEM-1 β-Lactamase Confirms Glutamate-166 as the Base Catalyst†

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A titanacyclopropane species, which is a key reaction intermediate in the Ti(OiPr)4-mediated double aryl Grignard addition to 1,2-di(pyridin-2-yl)ethyne and related alkynes, was isolated and fully characterized.


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2016 ◽  
Vol 283 (10) ◽  
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Vol 14 (4) ◽  
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