Amphoterin Includes a Sequence Motif Which Is Homologous to the Alzheimer's β-Amyloid Peptide (Aβ), Forms Amyloid Fibrils in Vitro, and Binds Avidly to Aβ†

Biochemistry ◽  
2001 ◽  
Vol 40 (34) ◽  
pp. 10032-10037 ◽  
Author(s):  
Jukka Kallijärvi ◽  
Matti Haltia ◽  
Marc H. Baumann
Keyword(s):  
Amyloid Fibrils ◽  
Amyloid Peptide ◽  
Sequence Motif ◽  
Β Amyloid ◽  
Β Amyloid Peptide

In vitro aggregation facilitates β-amyloid peptide-(25–35)-induced amnesia in the rat

1997 ◽  
Vol 319 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Stéphanie Delobette ◽  
Alain Privat ◽  
Tangui Maurice
Keyword(s):  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals Modulation of β-amyloid aggregation by graphene quantum dots

2019 ◽  
Vol 6 (6) ◽  
pp. 190271 ◽  
Author(s):  
Changliang Liu ◽  
Huan Huang ◽  
Lilusi Ma ◽  
Xiaocui Fang ◽  
Chen Wang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Structural Changes ◽  
Graphene Quantum Dots ◽  
Amyloid Peptide ◽  
Therapeutic Drug ◽  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Regulatory Effects ◽  
Β Amyloid Peptide

Misfolding and abnormal aggregation of β-amyloid peptide is associated with the onset and progress of Alzheimer's disease (AD). Therefore, modulating β-amyloid aggregation is critical for the treatment of AD. Herein, we studied the regulatory effects and mechanism of graphene quantum dots (GQDs) on 1–42 β-amyloid (Aβ 1–42 ) aggregation. GQDs displayed significant regulatory effects on the aggregation of Aβ 1–42 peptide as detected by thioflavin T (ThT) assay. Then, the changes of confirmations and structures induced by GQDs on the Aβ 1–42 aggregation were monitored by circular dichroism (CD), dynamic light scattering (DLS) and transmission electron microscope (TEM). The in vitro cytotoxicity experiments further demonstrated the feasibility of GQDs on the regulation of Aβ 1–42 aggregation. Meanwhile, the structural changes of a Aβ 1–42 /GQDs mixture in different pH revealed that electrostatic interaction was the major driving force in the co-assembly process of Aβ 1–42 and GQDs. The proposed mechanism of the regulatory effects of GQDs on the Aβ 1–42 aggregation was also deduced reasonably. This work not only demonstrated the potential feasibility of GQDs as therapeutic drug for AD but also clarified the regulatory mechanism of GQDs on the Aβ 1–42 aggregation.

scholarly journals Assessment of the Bioactivity of Antibodies against β-Amyloid Peptide in vitro and in vivo

2004 ◽  
Vol 1 (4-5) ◽  
pp. 160-167 ◽  
Author(s):  
M. Hasan Mohajeri ◽  
Meret N.M. Gaugler ◽  
Julia Martinez ◽  
Jay Tracy ◽  
Hong Li ◽  
...  
Keyword(s):  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

Synthesis and evaluation of arylquinones as BACE1 inhibitors, β-amyloid peptide aggregation inhibitors, and destabilizers of preformed β-amyloid fibrils

2011 ◽  
Vol 21 (8) ◽  
pp. 2183-2187 ◽  
Author(s):  
Andrea Ortega ◽  
Ángela Rincón ◽  
Karim L. Jiménez-Aliaga ◽  
Paloma Bermejo-Bescós ◽  
Sagrario Martín-Aragón ◽  
...  
Keyword(s):  
Amyloid Fibrils ◽  
Amyloid Peptide ◽  
Peptide Aggregation ◽  
Aggregation Inhibitors ◽  
Β Amyloid ◽  
Β Amyloid Peptide

Alzheimerʼs β-amyloid peptide is conformationally modified by apolipoprotein E in vitro

Neuroreport ◽  
1996 ◽  
Vol 7 (3) ◽  
pp. 721-725 ◽  
Author(s):  
Claudio Soto ◽  
Adam Golabek ◽  
Thomas Wisniewski ◽  
Eduardo M. Castaño
Keyword(s):  
Apolipoprotein E ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide
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