Stimulation of Site-Specific Topoisomerase II-Mediated DNA Cleavage by an N-Methylpyrrolecarboxamide-anilinoacridine Conjugate: Relation to DNA Binding

Biochemistry ◽  
1994 ◽  
Vol 33 (33) ◽  
pp. 9865-9874 ◽  
Author(s):  
Philippe Fosse ◽  
Brigitte Rene ◽  
Jean-Marie Saucier ◽  
Jean-Pierre Henichart ◽  
Michael J. Waring ◽  
...  
Keyword(s):  
Dna Binding ◽  
Dna Cleavage ◽  
Topoisomerase Ii ◽  
Site Specific ◽  
Stimulation Of

Site-Specific DNA Cleavage byChlorellaVirus Topoisomerase II†

Biochemistry ◽  
2002 ◽  
Vol 41 (39) ◽  
pp. 11761-11769 ◽  
Author(s):  
John M. Fortune ◽  
Jennifer S. Dickey ◽  
Oleg V. Lavrukhin ◽  
James L. Van Etten ◽  
R. Stephen Lloyd ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase Ii ◽  
Site Specific

scholarly journals Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors [see comments]

Blood ◽  
1996 ◽  
Vol 87 (7) ◽  
pp. 2649-2658 ◽  
Author(s):  
PD Aplan ◽  
DS Chervinsky ◽  
M Stanulla ◽  
WC Burhans
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase Ii ◽  
Model Systems ◽  
Site Specific ◽  
Breakpoint Cluster Region ◽  
Cluster Region ◽  
Topoisomerase Ii Inhibitors ◽  
Mll Gene ◽  
Secondary Leukemias ◽  
Double Strand Dna

The MLL gene located at 11q23 is frequently disrupted by chromosomal translocation in a wide spectrum of newly diagnosed acute leukemias. Recently, it has become apparent that the MLL gene is very frequently disrupted by chromosomal translocations in patients with secondary leukemias associated with chemotherapeutic regimens incorporating topoisomerase II inhibitors. These secondary leukemias associated with topoisomerase II inhibitors (most commonly teniposide, etoposide, or doxorubicin) have distinct clinical and biologic features which have led to the speculation that they are induced by treatment with topoisomerase II inhibitors. We have identified a site within the MLL breakpoint cluster region (bcr) that is highly sensitive to double- strand DNA cleavage induced by topoisomerase II inhibitors. This finding is quite specific and highly reproducible. Although it was initially discovered in malignant lymphoblasts isolated from a patient receiving multiagent chemotherapy, this site-specific double-strand DNA cleavage can be induced in tissue culture using malignant cell lines as well as peripheral blood from normal individuals. Site-specific cleavage occurs in a significant fraction of cells using a variety of model systems, is both time and dose dependent, and can be induced with either doxorubicin or etoposide. This site-specific cleavage maps to the same region as a consensus topoisomerase II cleavage site within the MLL bcr. These results suggest that site specific cleavage within the MLL bcr induced by topoisomerase II inhibitors may be an early step leading to MLL translocations and secondary leukemia.

Stimulation of topoisomerase II mediated DNA cleavage at specific sequence elements by the 2-nitroimidazole Ro 15-0216

Biochemistry ◽  
1990 ◽  
Vol 29 (41) ◽  
pp. 9507-9515 ◽  
Author(s):  
Boe S. Soerensen ◽  
Palle S. Jensen ◽  
Anni H. Andersen ◽  
Kent Christiansen ◽  
Jan Alsner ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase Ii ◽  
Specific Sequence ◽  
Sequence Elements ◽  
Stimulation Of

Stimulation by γ-carboline derivatives (simplified analogues of antitumor ellipticines) of site specific DNA cleavage by calf DNA topoisomerase II

1990 ◽  
Vol 39 (4) ◽  
pp. 669-676 ◽  
Author(s):  
Philippe Fossé ◽  
Brigitte René ◽  
Jean-Marie Saucier ◽  
Chi Hung Nguyen ◽  
Emile Bisagni ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Site Specific

Homoleptic bisterpyridyl complexes: Synthesis, characterization, DNA binding, DNA cleavage and topoisomerase II inhibition activity

2015 ◽  
Vol 432 ◽  
pp. 71-80 ◽  
Author(s):  
Priti Sinha ◽  
Niraj Kumari ◽  
Kanhaiya Singh ◽  
Kiran Singh ◽  
Lallan Mishra
Keyword(s):  
Dna Binding ◽  
Dna Cleavage ◽  
Topoisomerase Ii ◽  
Inhibition Activity

Similar sequence specificity of mitoxantrone and VM-26 stimulation of in vitro DNA cleavage by mammalian DNA topoisomerase II

Biochemistry ◽  
1993 ◽  
Vol 32 (12) ◽  
pp. 3038-3046 ◽  
Author(s):  
Giovanni Capranico ◽  
Paola De Isabella ◽  
Stella Tinelli ◽  
Mario Bigioni ◽  
Franco Zunino
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase Ii ◽  
Sequence Specificity ◽  
Dna Topoisomerase Ii ◽  
Similar Sequence ◽  
Dna Topoisomerase ◽  
Stimulation Of
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