Thermodynamics of sequence-specific glucocorticoid receptor-DNA interactions

Biochemistry ◽  
1994 ◽  
Vol 33 (19) ◽  
pp. 5955-5965 ◽  
Author(s):  
Thomas Lundbaeck ◽  
Johanna Zilliacus ◽  
Jan-Aake Gustafsson ◽  
Jan Carlstedt-Duke ◽  
Torleif Haerd
Keyword(s):  
Glucocorticoid Receptor ◽  
Dna Interactions

scholarly journals Allosteric Effects of Dexamethasone and RU486 on Glucocorticoid Receptor-DNA Interactions

2001 ◽  
Vol 277 (2) ◽  
pp. 1538-1543 ◽  
Author(s):  
Shilpa Pandit ◽  
Wayne Geissler ◽  
Georgianna Harris ◽  
Ayesha Sitlani
Keyword(s):  
Glucocorticoid Receptor ◽  
Dna Interactions

scholarly journals Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor

2002 ◽  
Vol 367 (3) ◽  
pp. 907-911 ◽  
Author(s):  
Sha TIAN ◽  
Hetti POUKKA ◽  
Jorma J. PALVIMO ◽  
Olli A. JÄNNE
Keyword(s):  
Glucocorticoid Receptor ◽  
Transcriptional Activity ◽  
Receptor Function ◽  
Dna Interactions ◽  
Mouse Mammary Tumour Virus ◽  
Cellular Targets ◽  
Attachment Sites ◽  
Protein Dna Interactions ◽  
Regulate Protein ◽  
Virus Promoter

Small ubiquitin-related modifier-1 (SUMO-1) is covalently attached to many cellular targets to regulate protein—protein and protein—DNA interactions, as well as localization and stability of the target protein. The SUMO-1-conjugating E2 enzyme Ubc9 is known to interact with the glucocorticoid receptor (GR), a ligand-dependent transcription factor. In the present study, we show that GR is post-translationally modified by SUMO-1 (sumoylated) in a ligand-enhanced fashion. We identify experimentally three consensus SUMO attachment sites, two in the N-terminal transactivation region and one in the ligand-binding domain of GR. The two N-terminal sites are the major acceptor sites for SUMO-1 attachment. Mutation of these sites enhances transcriptional activity of GR on minimal promoters, but has no clear effect on the more complex mouse mammary tumour virus promoter. Thus SUMO-1 modification of GR influences receptor function in a promoter context-dependent fashion.

scholarly journals Glucocorticoid Receptor–DNA Interactions: Binding Energetics Are the Primary Determinant of Sequence-Specific Transcriptional Activity

2012 ◽  
Vol 422 (1) ◽  
pp. 18-32 ◽  
Author(s):  
David L. Bain ◽  
Qin Yang ◽  
Keith D. Connaghan ◽  
James P. Robblee ◽  
Michael T. Miura ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Transcriptional Activity ◽  
Dna Interactions ◽  
Binding Energetics ◽  
Primary Determinant

Histone deacetylase 6– HDAC6– a new regulator of glucocorticoid receptor-mediated metabolic processes

2010 ◽  
Vol 5 (S 01) ◽  
Author(s):  
R Winkler ◽  
M Clemenz ◽  
M Bloch ◽  
A Foryst-Ludwig ◽  
C Böhm ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Histone Deacetylase ◽  
Histone Deacetylase 6 ◽  
Metabolic Processes

Crosstalk between glucocorticoid receptor bound corticosteroids and the TGF-β-Smad 3 pathway in liver cells

2006 ◽  
Vol 44 (01) ◽  
Author(s):  
U Bolkenius ◽  
D Hahn ◽  
AM Gressner ◽  
K Breitkopf ◽  
L Wickert
Keyword(s):  
Glucocorticoid Receptor ◽  
Liver Cells ◽  
Smad 3
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