Molecular Basis of the Medium-Chain Fatty Acyl-CoA Dehydrogenase-Catalyzed "Oxidase" Reaction: pH-Dependent Distribution of Intermediary Enzyme Species during Catalysis

Biochemistry ◽  
1994 ◽  
Vol 33 (15) ◽  
pp. 4738-4744 ◽  
Author(s):  
Jeffrey K. Johnson ◽  
N. Ravi Kumar ◽  
D. K. Srivastava
Keyword(s):  
Molecular Basis ◽  
Fatty Acyl ◽  
Medium Chain ◽  
Ph Dependent ◽  
Oxidase Reaction ◽  
Enzyme Species

scholarly journals Molecular Basis of Medium-Chain Length-PHA Metabolism of Pseudomonas putida

2020 ◽  
pp. 89-114
Author(s):  
Maria Tsampika Manoli ◽  
Natalia Tarazona ◽  
Aranzazu Mato ◽  
Beatriz Maestro ◽  
Jesús M. Sanz ◽  
...  
Keyword(s):  
Pseudomonas Putida ◽  
Chain Length ◽  
Molecular Basis ◽  
Medium Chain ◽  
Medium Chain Length

Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states

2014 ◽  
Vol 16 (31) ◽  
pp. 16547-16562 ◽  
Author(s):  
M. Micaela Gonzalez ◽  
M. Paula Denofrio ◽  
Fernando S. García Einschlag ◽  
Carlos A. Franca ◽  
Reinaldo Pis Diez ◽  
...  
Keyword(s):  
Excited States ◽  
Molecular Basis ◽  
Electronic Excited States ◽  
Ph Dependent ◽  
Dependent Interaction

The nature of nucleotide and the pH modulate the type of complexes formed and the dynamic deactivation processes.

Molecular Basis of the Functional Divergence of Fatty Acyl-AMP Ligase Biosynthetic Enzymes of Mycobacterium tuberculosis

2012 ◽  
Vol 416 (2) ◽  
pp. 221-238 ◽  
Author(s):  
Aneesh Goyal ◽  
Priyanka Verma ◽  
Madhankumar Anandhakrishnan ◽  
Rajesh S. Gokhale ◽  
Rajan Sankaranarayanan
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Molecular Basis ◽  
Functional Divergence ◽  
Fatty Acyl ◽  
Biosynthetic Enzymes

scholarly journals Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways

2013 ◽  
Vol 110 (40) ◽  
pp. 15973-15978 ◽  
Author(s):  
A. L. Garland ◽  
W. G. Walton ◽  
R. D. Coakley ◽  
C. D. Tan ◽  
R. C. Gilmore ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Molecular Basis ◽  
Ph Dependent

scholarly journals A universal pocket in Fatty acyl-AMP ligases ensures redirection of fatty acid pool away from Coenzyme A-based activation

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Gajanan Shrikant Patil ◽  
Priyadarshan Kinatukara ◽  
Sudipta Mondal ◽  
Sakshi Shambhavi ◽  
Ketan D Patel ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Binding Sites ◽  
Molecular Basis ◽  
Coenzyme A ◽  
Acyl Carrier Protein ◽  
Fatty Acyl ◽  
Carrier Protein ◽  
Binding Pockets ◽  
Fatty Acid Pool ◽  
Do So

Fatty acyl-AMP ligases (FAALs) channelize fatty acids towards biosynthesis of virulent lipids in mycobacteria and other pharmaceutically or ecologically important polyketides and lipopeptides in other microbes. They do so by bypassing the ubiquitous coenzyme A-dependent activation and rely on the acyl carrier protein-tethered 4'-phosphopantetheine (holo-ACP). The molecular basis of how FAALs strictly reject chemically identical and abundant acceptors like coenzyme A (CoA) and accept holo-ACP unlike other members of the ANL superfamily remains elusive. We show FAALs have plugged the promiscuous canonical CoA-binding pockets and utilize highly selective alternative binding sites. These alternative pockets can distinguish adenosine 3', 5'-bisphosphate-containing CoA from holo-ACP and thus FAALs can distinguish between CoA and holo-ACP. These exclusive features helped identify the omnipresence of FAAL-like proteins and their emergence in plants, fungi, and animals with unconventional domain organisations. The universal distribution of FAALs suggests they are parallelly evolved with FACLs for ensuring a CoA-independent activation and redirection of fatty acids towards lipidic metabolites.

Molecular Basis of Isovaleric Acidemia and Medium-Chain Acyl-CoA Dehydrogenase Deficiency

Enzyme ◽  
1987 ◽  
Vol 38 (1-4) ◽  
pp. 91-107 ◽  
Author(s):  
Kay Tanaka ◽  
Yasuyuki Ikeda ◽  
Yoichi Matsubara ◽  
David B. Hamyna
Keyword(s):  
Molecular Basis ◽  
Dehydrogenase Deficiency ◽  
Medium Chain ◽  
Isovaleric Acidemia ◽  
Chain Acyl

Changes in lipid composition of liver microsomes and fatty acyl-CoA desaturase activities induced by medium chain triglyceride feeding

Lipids ◽  
1989 ◽  
Vol 24 (5) ◽  
pp. 383-388 ◽  
Author(s):  
José L. Periago ◽  
María L. Pita ◽  
María A. Sanchez del Castillo ◽  
Guillermo Caamaño ◽  
María D. Suárez
Keyword(s):  
Lipid Composition ◽  
Liver Microsomes ◽  
Medium Chain Triglyceride ◽  
Fatty Acyl ◽  
Medium Chain
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