Interaction of a Mitochondrial Presequence with Lipid Membranes:  Role of Helix Formation for Membrane Binding and Perturbation†

Biochemistry ◽  
2000 ◽  
Vol 39 (50) ◽  
pp. 15297-15305 ◽  
Author(s):  
Torsten Wieprecht ◽  
Ognjan Apostolov ◽  
Michael Beyermann ◽  
Joachim Seelig
Keyword(s):  
Lipid Membranes ◽  
Membrane Binding ◽  
Helix Formation

scholarly journals Cholesterol provides nonsacrificial protection of membrane lipids from chemical damage at air–water interface

2018 ◽  
Vol 115 (13) ◽  
pp. 3255-3260 ◽  
Author(s):  
Xinxing Zhang ◽  
Kevin M. Barraza ◽  
J. L. Beauchamp
Keyword(s):  
Lipid Membranes ◽  
Membrane Lipids ◽  
Oh Radicals ◽  
Significant Finding ◽  
Water Interface ◽  
Unsaturated Lipids ◽  
Air Water Interface ◽  
Liquid Ordered ◽  
Ester Linkage

The role of cholesterol in bilayer and monolayer lipid membranes has been of great interest. On the biophysical front, cholesterol significantly increases the order of the lipid packing, lowers the membrane permeability, and maintains membrane fluidity by forming liquid-ordered–phase lipid rafts. However, direct observation of any influence on membrane chemistry related to these cholesterol-induced physical properties has been absent. Here we report that the addition of 30 mol % cholesterol to 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) or 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (POPG) monolayers at the air–water interface greatly reduces the oxidation and ester linkage cleavage chemistries initiated by potent chemicals such as OH radicals and HCl vapor, respectively. These results shed light on the indispensable chemoprotective function of cholesterol in lipid membranes. Another significant finding is that OH oxidation of unsaturated lipids generates Criegee intermediate, which is an important radical involved in many atmospheric processes.

The role of cholesterol in lipid membranes

1969 ◽  
Vol 173 (1) ◽  
pp. 143-145 ◽  
Author(s):  
J. De Gier ◽  
J.G. Mandersloot ◽  
L.L.M. Van Deenen
Keyword(s):  
Lipid Membranes

Role of Cationic Groove and Hydrophobic Residues in Phosphatidylinositol-Dependent Membrane-Binding Properties of Tks5-Phox Homology Domain

2018 ◽  
Vol 3 (4) ◽  
pp. 1205-1214 ◽  
Author(s):  
Sukhamoy Gorai ◽  
Debasish Paul ◽  
Rituparna Borah ◽  
Nandan Haloi ◽  
Manas Kumar Santra ◽  
...  
Keyword(s):  
Membrane Binding ◽  
Binding Properties ◽  
Hydrophobic Residues ◽  
Phox Homology

scholarly journals Evaluating the Role of Oxidative Stress in Acute Ischemic Stroke

2020 ◽  
Vol 11 (01) ◽  
pp. 156-159
Author(s):  
Bindu Menon ◽  
Krishnan Ramalingam ◽  
Rajeev Kumar
Keyword(s):  
Oxidative Stress ◽  
Ischemic Stroke ◽  
Acute Stroke ◽  
Acute Ischemic Stroke ◽  
Lipid Membranes ◽  
Demographic Data ◽  
Stroke Severity ◽  
Stroke Patients ◽  
Antioxidant Power

Abstract Background The role of oxidative stress in neuronal injury due to ischemic stroke has been an interesting topic in stroke research. Malondialdehyde (MDA) has emerged as a sensitive oxidative stress biomarker owing to its ability to react with the lipid membranes. Total antioxidant power (TAP) is another biomarker to estimate the total oxidative stress in stroke patients. We aimed to determine the oxidative stress in acute stroke patients by measuring MDA and TAP. Materials and Methods MDA and TAP were determined in 100 patients with ischemic stroke and compared with that in 100 age- and sex-matched healthy adults. Demographic data, stroke severity measured by the National Institutes of Health Stroke Scale (NIHSS), and disability measured by the Barthel index (BI) were recorded. The association of MDA and TAP with other variables was analyzed by paired t-test. Results Of the whole sample, 74% represented males. The mean NIHSS score was 13.11 and BI was 38.87. MDA was significantly higher in stroke patients (7.11 ± 1.67) than in controls (1.64 ± 0.82; p = 0.00). TAP was significantly lower in stroke patients (5.72 ± 1.41) than in controls (8.53 ± 2.4; p = 0.00). The lipid profile and blood sugar levels were also significantly higher in stroke patients. There was no association of MDA and TAP with other variables. Conclusion We found that oxidative stress was associated with acute ischemic stroke. However, we could not establish an association between oxidative stress and the severity of acute stroke.

Oxidation of Polyunsaturated Lipid Membranes by Photocatalytic Titanium Dioxide Nanoparticles: Role of pH and Salinity

2020 ◽  
Vol 12 (29) ◽  
pp. 32446-32460 ◽  
Author(s):  
Elisa Parra-Ortiz ◽  
Sara Malekkhaiat Häffner ◽  
Thomas Saerbeck ◽  
Maximilian W. A. Skoda ◽  
Kathryn L. Browning ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Lipid Membranes ◽  
Titanium Dioxide Nanoparticles

scholarly journals Essential Role of B-helix Calcium Binding Sites in Annexin V-Membrane Binding

2004 ◽  
Vol 279 (39) ◽  
pp. 40351-40357 ◽  
Author(s):  
Ming Jin ◽  
Christina Smith ◽  
Heng-Yu Hsieh ◽  
Donald F. Gibson ◽  
Jonathan F. Tait
Keyword(s):  
Binding Sites ◽  
Calcium Binding ◽  
Essential Role ◽  
Membrane Binding ◽  
Annexin V ◽  
Calcium Binding Sites

scholarly journals Fluid deformable surfaces

2019 ◽  
Vol 878 ◽  
pp. 1-4 ◽  
Author(s):  
A. Voigt
Keyword(s):  
Lipid Membranes ◽  
Shape Change ◽  
Governing Equations ◽  
Tight Coupling ◽  
Tangential Flow ◽  
Deformable Surfaces ◽  
Bending Elasticity ◽  
Natural Element ◽  
Numerical Tools

Lipid membranes are examples of fluid deformable surfaces, which can be viewed as two-dimensional viscous fluids with bending elasticity. With this solid–fluid duality any shape change contributes to tangential flow and vice versa any tangential flow on a curved surface induces shape deformations. This tight coupling between shape and flow makes curvature a natural element of the governing equations. The modelling and numerical tools outlined in Torres-Sánchez et al. (J. Fluid Mech., vol. 872, 2019, pp. 218–271) open a new field of study by enabling the exploration of the role of curvature in this context.

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