Proton Nuclear Magnetic Resonance and Distance Geometry/Simulated Annealing Studies on the Variant-1 Neurotoxin from the New World Scorpion Centruroides sculpturatus Ewing

Biochemistry ◽  
1994 ◽  
Vol 33 (9) ◽  
pp. 2468-2475 ◽  
Author(s):  
Weontae Lee ◽  
Michael J. Jablonsky ◽  
Dean D. Watt ◽  
N. Rama Krishna
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Simulated Annealing ◽  
Magnetic Resonance ◽  
New World ◽  
Distance Geometry ◽  
Proton Nuclear Magnetic Resonance ◽  
Centruroides Sculpturatus ◽  
Nuclear Magnetic

Proton nuclear magnetic resonance characterization of the aromatic residues in the variant-3 neurotoxin from Centruroides sculpturatus Ewing

Biochemistry ◽  
1989 ◽  
Vol 28 (4) ◽  
pp. 1556-1562 ◽  
Author(s):  
N. Rama Krishna ◽  
David G. Nettesheim ◽  
Rachel E. Klevit ◽  
Gary Drobny ◽  
Dean D. Watt ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Proton Nuclear Magnetic Resonance ◽  
Aromatic Residues ◽  
Centruroides Sculpturatus ◽  
Nuclear Magnetic

scholarly journals N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl] quinoline]-acetamide

Molbank ◽  
10.3390/m1213 ◽  
2021 ◽  
Vol 2021 (2) ◽  
pp. M1213
Author(s):  
Paolo Coghi ◽  
Jerome P. L. Ng ◽  
Ali Adnan Nasim ◽  
Vincent Kam Wai Wong
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Quantum Coherence ◽  
Biologically Active ◽  
Proton Nuclear Magnetic Resonance ◽  
Dipolar Cycloaddition ◽  
Heteronuclear Single Quantum Coherence ◽  
Pharmacokinetic Properties ◽  
Nuclear Magnetic

The 1,2,3-triazole is a well-known biologically active pharmacophore constructed by the copper-catalyzed azide–alkyne cycloaddition. We herein reported the synthesis of 4-amino-7-chloro-based [1,2,3]-triazole hybrids via Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of 4-azido-7-chloroquinoline with an alkyne derivative of acetaminophen. The compound was fully characterized by Fourier-transform infrared (FTIR), proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), heteronuclear single quantum coherence (HSQC), ultraviolet (UV) and high-resolution mass spectroscopies (HRMS). This compound was screened in vitro with different normal and cancer cell lines. The drug likeness of the compound was also investigated by predicting its pharmacokinetic properties.

Sign in / Sign up

Export Citation Format

Share Document