Reaction pathway for inhibition of blood coagulation factor Xa by tick anticoagulant peptide

Biochemistry ◽  
1992 ◽  
Vol 31 (23) ◽  
pp. 5374-5380 ◽  
Author(s):  
Susan P. Jordan ◽  
Shi Shan Mao ◽  
Sidney D. Lewis ◽  
Jules A. Shafer
Keyword(s):  
Blood Coagulation ◽  
Reaction Pathway ◽  
Factor Xa ◽  
Coagulation Factor ◽  
Tick Anticoagulant Peptide

Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa

Science ◽  
1990 ◽  
Vol 248 (4955) ◽  
pp. 593-596 ◽  
Author(s):  
L Waxman ◽  
D. Smith ◽  
K. Arcuri ◽  
G. Vlasuk
Keyword(s):  
Blood Coagulation ◽  
Factor Xa ◽  
Coagulation Factor ◽  
Tick Anticoagulant Peptide

Tick Anticoagulant Peptide (TAP) Is a Novel Inhibitor of Blood Coagulation Factor Xa

Science ◽  
1990 ◽  
pp. 1473-1473
Author(s):  
L. Waxman ◽  
D. E. Smith ◽  
K. E. Arcuri ◽  
G. P. Vlasuk
Keyword(s):  
Blood Coagulation ◽  
Factor Xa ◽  
Coagulation Factor ◽  
Tick Anticoagulant Peptide

Tick Anticoagulant Peptide (TAP) Is a Novel Inhibitor of Blood Coagulation Factor Xa

Science ◽  
1990 ◽  
Vol 248 (4962) ◽  
pp. 1473-1473
Author(s):  
L. Waxman ◽  
D. E. Smith ◽  
K. E. Arcuri ◽  
G. P. Vlasuk
Keyword(s):  
Blood Coagulation ◽  
Factor Xa ◽  
Coagulation Factor ◽  
Tick Anticoagulant Peptide

scholarly journals Characterization of recombinant tick anticoagulant peptide. A highly selective inhibitor of blood coagulation factor Xa.

1990 ◽  
Vol 265 (29) ◽  
pp. 17746-17752 ◽  
Author(s):  
M P Neeper ◽  
L Waxman ◽  
D E Smith ◽  
C A Schulman ◽  
M Sardana ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Factor Xa ◽  
Coagulation Factor ◽  
Selective Inhibitor ◽  
Tick Anticoagulant Peptide

Two parallel prothrombin activator systems in Australian rough-scaled snake, Tropidechis carinatus

2005 ◽  
Vol 93 (01) ◽  
pp. 40-47 ◽  
Author(s):  
Md. Abu Reza ◽  
Sanjay Swarup ◽  
Manjunatha Kini
Keyword(s):  
Blood Coagulation ◽  
Blood Clotting ◽  
Cdna Sequence ◽  
Factor Xa ◽  
Coagulation Factor ◽  
Venom Gland ◽  
Factor X ◽  
Specific Expression ◽  
Life Saving ◽  
Sequence Encoding

SummaryIt is uncommon for similar pathways/systems to be involved in highly divergent functions within single organisms. Earlier, we have shown that trocarin D, a venom prothrombin activator, from the Australian rough-scaled snake Tropidechis carinatus, is structurally and functionally similar to the blood coagulation factor Xa (FXa). The presence of a haemostatic system in these snakes implies that they have two parallel prothrombin activating systems: one in the plasma, that participates in the life saving process of blood clotting and the other in their venom, where it acts as a toxin. Here, we report the complete cDNA sequence encoding the blood coagulation factor X (FX) from the liver of T. carinatus. Deduced T. carinatus FX sequence shows ~80% identity with trocarin D but ~50% identity with the mammalian FX. Our present study confirms the presence of two separate genes – one each for FX and trocarin D, that code for similar proteins in T. carinatus snake. These two genes have different expression sites and divergent uses suggesting that snake venom prothrombin activators have probably evolved by the duplication of the liver FX gene and subsequently marked for tissue-specific expression in the venom gland.

ChemInform Abstract: Dibasic (Amidinoaryl)propanoic Acid Derivatives as Novel Blood Coagulation Factor Xa Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 25 (33) ◽  
pp. no-no
Author(s):  
T. NAGAHARA ◽  
Y. YOKOYAMA ◽  
K. INAMURA ◽  
S. KATAKURA ◽  
S. KOMORIYA ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Factor Xa ◽  
Coagulation Factor ◽  
Factor Xa Inhibitors ◽  
Propanoic Acid

Chlorothiophenecarboxamides as P1 surrogates of inhibitors of blood coagulation factor Xa

2004 ◽  
Vol 14 (23) ◽  
pp. 5817-5822 ◽  
Author(s):  
Werner W.K.R. Mederski ◽  
Bertram Cezanne ◽  
Christoph van Amsterdam ◽  
Karl-Ulrich Bühring ◽  
Dieter Dorsch ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Factor Xa ◽  
Coagulation Factor
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