Protein kinase A dependent membrane protein phosphorylation and chloride conductance in endosomal vesicles from kidney cortex

Biochemistry ◽  
1992 ◽  
Vol 31 (1) ◽  
pp. 175-181 ◽  
Author(s):  
William W. Reenstra ◽  
Ivan Sabolic ◽  
Hae Rahn Bae ◽  
A. S. Verkman
Keyword(s):  
Protein Kinase ◽  
Membrane Protein ◽  
Protein Phosphorylation ◽  
Protein Kinase A ◽  
Chloride Conductance ◽  
Kidney Cortex ◽  
Endosomal Vesicles ◽  
Kinase A

Angiotensin II Inhibits Protein Kinase A–Dependent Chloride Conductance in Heart via Pertussis Toxin–Sensitive G Proteins

Circulation ◽  
1997 ◽  
Vol 95 (1) ◽  
pp. 197-204 ◽  
Author(s):  
Kazuhiko Obayashi ◽  
Minoru Horie ◽  
Lai-Hua Xie ◽  
Kunihiko Tsuchiya ◽  
Akira Kubota ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
G Proteins ◽  
Pertussis Toxin ◽  
Chloride Conductance ◽  
Kinase A

scholarly journals Changes in Rat Myometrial Plasma Membrane Protein Kinase A Are Confined to Parturition

2010 ◽  
Vol 17 (7) ◽  
pp. 696-704 ◽  
Author(s):  
Chun-Ying Ku ◽  
Dilyara A. Murtazina ◽  
Yoon-Sun Kim ◽  
Robert E. Garfield ◽  
Barbara M. Sanborn
Keyword(s):  
Plasma Membrane ◽  
Protein Kinase ◽  
Membrane Protein ◽  
Protein Kinase A ◽  
Plasma Membrane Protein ◽  
Kinase A

Inhibition of the cardiac protein kinase A-dependent chloride conductance by endothelin-1

Nature ◽  
1994 ◽  
Vol 370 (6487) ◽  
pp. 297-300 ◽  
Author(s):  
Andrew F. James ◽  
Lai-Hua Xie ◽  
Yasushi Fujitani ◽  
Seiji Hayashi ◽  
Minoru Horie
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Chloride Conductance ◽  
Endothelin 1 ◽  
Kinase A

scholarly journals CD9 regulates transcription factor GCM1 and ERVWE1 expression through the cAMP/protein kinase A signaling pathway

Reproduction ◽  
2009 ◽  
Vol 138 (6) ◽  
pp. 945-951 ◽  
Author(s):  
Yoshikage Muroi ◽  
Toshihiro Sakurai ◽  
Akira Hanashi ◽  
Kentaro Kubota ◽  
Kentaro Nagaoka ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Protein Kinase ◽  
Membrane Protein ◽  
Protein Kinase A ◽  
Signaling Pathway ◽  
Endogenous Retrovirus ◽  
Regulatory Mechanisms ◽  
Human Endogenous Retrovirus ◽  
Envelope Gene ◽  
Kinase A

ERVWE1 (SYNCYTIN-1), a membrane protein originating from the envelope gene of human endogenous retrovirus-W (HERV-W), mediates the fusion of mononucleated cytotrophoblasts into multinucleated syncytiotrophoblast. Though ERVWE1 has been characterized since its discovery, regulatory mechanisms associated with ERVWE1 expression have not been firmly established. We hypothesized that membrane protein CD9, involved in cell–cell fusion of fertilization and myogenesis, could be involved in the regulation ofERVWE1gene expression. In this study, regulatory mechanisms of ERVWE1 expression were studied using human choriocarcinoma BeWo cells. Forskolin is an activator of adenylate cyclase, which increased CD9 and ERVWE1 expression. The increase in CD9 expression was inhibited by a protein kinase A (PKA) inhibitor, Rp-cAMPS. These results indicate that CD9 expression is regulated by the cAMP/PKA signaling pathway. Overexpression ofCD9increased expression levels of ERVWE1 as well as GCM1 (hGCMa), which is a transcription factor known to activateERVWE1gene transcription. However, high ERVWE1 expression induced byCD9overexpression did not result in the increase in chorionic gonadotropin, beta polypeptide production. Moreover,CD9-induced increase inERVWE1andGCM1expressions were inhibited by Rp-cAMPS. These results suggest that CD9 increases GCM1 expression via the cAMP/PKA signaling pathway, resulting in the increase in ERVWE1 expression.

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