A functional reconstitution of the .gamma.-aminobutyric acid transporter from synaptic vesicles using artificial ion gradients

Biochemistry ◽  
1991 ◽  
Vol 30 (51) ◽  
pp. 11795-11800 ◽  
Author(s):  
Johannes W. Hell ◽  
Lambert Edelmann ◽  
Joachim Hartinger ◽  
Reinhard Jahn
Keyword(s):  
Synaptic Vesicles ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Ion Gradients ◽  
Acid Transporter

scholarly journals A gamma-aminobutyric acid transporter driven by a proton pump is present in synaptic-like microvesicles of pancreatic beta cells.

1993 ◽  
Vol 90 (11) ◽  
pp. 5317-5321 ◽  
Author(s):  
A. Thomas-Reetz ◽  
J. W. Hell ◽  
M. J. During ◽  
C. Walch-Solimena ◽  
R. Jahn ◽  
...  
Keyword(s):  
Beta Cells ◽  
Proton Pump ◽  
Pancreatic Beta Cells ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Acid Transporter

scholarly journals Insights into binding events of GABA- and Tiagabine- analogues in the Gamma-Aminobutyric Acid Transporter 1 by means of Molecular Modelling

2012 ◽  
Vol 4 (S1) ◽  
Author(s):  
Barbara Zdrazil ◽  
Andreas Jurik ◽  
Regina Reicherstorfer ◽  
Thomas Stockner ◽  
Harald H Sitte ◽  
...  
Keyword(s):  
Molecular Modelling ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Acid Transporter

Organization of neurons labeled by antibodies to gamma-aminobutyric acid (GABA) in the superior colliculus of the Rhesus monkey

1991 ◽  
Vol 6 (1) ◽  
pp. 75-92 ◽  
Author(s):  
R. Ranney Mize ◽  
Chang-Jin Jeon ◽  
Omar L. Hamada ◽  
Robert F. Spencer
Keyword(s):  
Superior Colliculus ◽  
Synaptic Vesicles ◽  
Mammalian Species ◽  
Average Diameter ◽  
Cell Types ◽  
Aminobutyric Acid ◽  
Small Cells ◽  
Gamma Aminobutyric Acid ◽  
Synaptic Organization ◽  
Synaptic Contacts

AbstractThe inhibitory neurotransmitter gamma-aminobutyric acid (GABA) is found in the superior colliculus (SC) of many mammalian species. In cat, several distinct classes of putative GABAergic neuron have been identified using antibodies directed against the neurotransmitter. It is not known whether these classes are found in other species. To study this, we examined the distribution, morphology, ultrastructure, and synaptic organization of GABA immunoreactive neurons in the SC of the Rhesus monkey (Macaca mulatta). Antibody-labeled neurons were distributed throughout the monkey SC, but were most densely concentrated within the zonal and superficial gray layers (32.5% of the total). These neurons were all small cells ranging from 6.6–16.3 μm in average diameter, and had granule, pyriform, and horizontal morphologies. Four types of labeled profile were identified in single ultrathin sections with the electron microscope. Presynaptic dendrites (PSDs) contained pleomorphic vesicles, received synaptic input from unlabeled axon terminals, and sometimes formed symmeytric synaptic contacts with postsynaptic profiles. Two subtypes were found. One type contained loose accumulations of synaptic vesicles throughout the profile and had a distinctive varicose shape. The other type contained small discrete clusters of synaptic vesicles near the site of synaptic apposition. The former were much more common. Profiles with typical axon terminal morphology were also found. These profiles usually contained numerous flattened vesicles and formed symmetric synapses with postsynaptic profiles, both dendrites and cell bodies. Some conventional dendrites and myelinated axons were also labeled. Serial ultrathin section reconstructions revealed that PSDs formed complex synaptic relationships with other elements. Retinal terminals, identified by their characteristic pale mitochondria, established synaptic contacts with both types of PSD. These PSDs also established contact with each other, providing a possible anatomical substrate for disinhibition. We conclude that the monkey SC has multiple GABAergic cell types, similar to those found in cat may represent an organization common to both mammals and some other vertebrate species. The circuitry established by these cell types may provide a mechanism for disinhibition as well as inhibition in the mammalian SC.

The Antinociceptive Effect of SNAP5114, a Gamma-Aminobutyric Acid Transporter-3 Inhibitor, in Rat Experimental Pain Models

2013 ◽  
Vol 116 (5) ◽  
pp. 1162-1169 ◽  
Author(s):  
Kazunori Kataoka ◽  
Koji Hara ◽  
Yasunori Haranishi ◽  
Tadanori Terada ◽  
Takeyoshi Sata
Keyword(s):  
Antinociceptive Effect ◽  
Experimental Pain ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Pain Models ◽  
Acid Transporter
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