Kinetics and regulation of two catalytic subunits of cAMP-dependent protein kinase from Aplysia californica

Biochemistry ◽  
1991 ◽  
Vol 30 (42) ◽  
pp. 10246-10255 ◽  
Author(s):  
Stephen Cheley ◽  
Hagan Bayley
Keyword(s):  
Protein Kinase ◽  
Aplysia Californica ◽  
Dependent Protein Kinase ◽  
Catalytic Subunits ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein

scholarly journals Evolutionary Paths of the cAMP-Dependent Protein Kinase (PKA) Catalytic Subunits

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60935 ◽  
Author(s):  
Kristoffer Søberg ◽  
Tore Jahnsen ◽  
Torbjørn Rognes ◽  
Bjørn S. Skålhegg ◽  
Jon K. Laerdahl
Keyword(s):  
Protein Kinase ◽  
Dependent Protein Kinase ◽  
Catalytic Subunits ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein ◽  
Evolutionary Paths

scholarly journals Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha.

1996 ◽  
Vol 134 (5) ◽  
pp. 1241-1254 ◽  
Author(s):  
T Imaizumi-Scherrer ◽  
D M Faust ◽  
J C Bénichou ◽  
R Hellio ◽  
M C Weiss
Keyword(s):  
Protein Kinase ◽  
Neuromuscular Junction ◽  
Synaptic Activity ◽  
Fetal Life ◽  
Dependent Protein Kinase ◽  
Catalytic Subunits ◽  
Epsilon Subunit ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein ◽  
High Level

Using probes specific for cAMP-dependent protein kinase, we have analyzed by in situ hybridization the patterns of expression of regulatory and catalytic subunits in mouse embryos and in adult muscle. RI alpha transcripts are distributed in muscle fibers exactly as acetylcholinesterase, showing that this RNA is localized at the neuromuscular junction. The transcript levels increase upon denervation of the muscle, but the RNA remains localized, indicating a regulation pattern similar to that of the epsilon subunit of nicotinic acetylcholine receptor. RI alpha transcripts have accumulated in the muscle by day 12 of mouse embryogenesis, and localization is established by day 14, at about the time of formation of junctions. This localization is maintained throughout development and in the adult. Immunocytochemical analysis has demonstrated that RI alpha protein is also localized. In addition, RI alpha recruits C alpha protein to the junction, providing at this site the potential for local responsiveness to cAMP. PKA could be implicated in the establishment and/or maintenance of the unique pattern of gene expression occurring at the junction, or in the modulation of synaptic activity via protein phosphorylation. Embryonic skeletal muscle shows a high level of C alpha transcripts and protein throughout the fiber; the transcripts are already present by day 12 of embryogenesis, and their elevated level is maintained only through fetal life. In the adult, the C alpha hybridization signal of muscle is weak and homogeneous.

Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase

Cell ◽  
1987 ◽  
Vol 50 (2) ◽  
pp. 277-287 ◽  
Author(s):  
Takashi Toda ◽  
Scott Cameron ◽  
Philip Sass ◽  
Mark Zoller ◽  
Michael Wigler
Keyword(s):  
Protein Kinase ◽  
Dependent Protein Kinase ◽  
Catalytic Subunits ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein
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