Transcriptional regulation of the Xenopus laevis B.beta. fibrinogen subunit gene by glucocorticoids and hepatocyte nuclear factor 1: Analysis by transfection into primary liver cells

Biochemistry ◽  
1993 ◽  
Vol 32 (43) ◽  
pp. 11627-11637 ◽  
Author(s):  
Lewis R. Roberts ◽  
LaNita A. Nichols ◽  
Lene J. Holland
Keyword(s):  
Transcriptional Regulation ◽  
Xenopus Laevis ◽  
Liver Cells ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Subunit Gene ◽  
Nuclear Factor 1

scholarly journals Transcriptional Regulation of CYP2B6 Expression by Hepatocyte Nuclear Factor 3β in Human Liver Cells

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0150587 ◽  
Author(s):  
Linhao Li ◽  
Daochuan Li ◽  
Scott Heyward ◽  
Hongbing Wang
Keyword(s):  
Transcriptional Regulation ◽  
Human Liver ◽  
Liver Cells ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Human Liver Cells

scholarly journals Transcriptional Regulation of the Angptl8 Gene by Hepatocyte Nuclear Factor-1 in the Murine Liver

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Takuya Watanabe ◽  
Atsushi Ozawa ◽  
Shinnosuke Masuda ◽  
Satoshi Yoshino ◽  
Emi Ishida ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Murine Liver ◽  
Nuclear Factor 1

The human beta fibrinogen promoter contains a hepatocyte nuclear factor 1-dependent interleukin-6-responsive element

1993 ◽  
Vol 13 (2) ◽  
pp. 1183-1193
Author(s):  
J Dalmon ◽  
M Laurent ◽  
G Courtois
Keyword(s):  
Binding Site ◽  
Acute Phase ◽  
Interleukin 6 ◽  
Constitutive Expression ◽  
Nuclear Proteins ◽  
Functional Coupling ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Tissue Specific ◽  
Nuclear Factor 1

Acute-phase reactants are liver proteins whose synthesis is positively or negatively regulated during inflammation. The main mediators of this phenomenon are glucocorticoids and interleukin-6 (IL-6), a pleiotropic cytokine that also controls hematopoiesis. Functional analysis of several acute-phase reactant promoter regions has identified two major DNA motifs used by IL-6-regulated genes. The first one corresponds to a CTGG(G/A)AA sequence, and the other is a binding site for members of the C/EBP family of nuclear proteins. We have previously shown that the human beta fibrinogen (beta Fg) promoter contains an IL-6-responsive region, located between bp -150 and -67 (P. Huber, M. Laurent, and J. Dalmon, J. Biol. Chem. 265:5695-5701, 1990). In this study, using DNase I footprinting, mobility shift assays, and mutagenesis, we demonstrate that at least three subdomains of this region are necessary to observe a full response to IL-6. The most distal contains a CTGGGAA motif, and its mutation inhibits IL-6 stimulation. Another, which is able to interact with several distinct nuclear proteins, among them members of the C/EBP family, is dispensable for IL-6 induction but plays an important role in the constitutive expression of beta Fg. Finally, a proximal hepatocyte nuclear factor 1 binding site, already described as the major determinant of beta Fg tissue-specific expression, is also required for IL-6 stimulation. These results indicate a complex interplay between nuclear proteins within the beta Fg IL-6-responsive region and suggest a tight functional coupling between the tissue-specific and inducible elements.

scholarly journals Hepatitis C Virus Infection Suppresses GLUT2 Gene Expression via Downregulation of Hepatocyte Nuclear Factor 1 

2012 ◽  
Vol 86 (23) ◽  
pp. 12903-12911 ◽  
Author(s):  
C. Matsui ◽  
I. Shoji ◽  
S. Kaneda ◽  
I. R. Sianipar ◽  
L. Deng ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Hepatitis C Virus Infection ◽  
Glut2 Gene ◽  
Nuclear Factor 1
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