Structural organization and chromosomal assignment of the gene encoding the human heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor

Biochemistry ◽  
1993 ◽  
Vol 32 (31) ◽  
pp. 7932-7938 ◽  
Author(s):  
Zhou Fen ◽  
Mandeep S. Dhadly ◽  
Masao Yoshizumi ◽  
Robert J. Hilkert ◽  
Thomas Quertermous ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Diphtheria Toxin ◽  
Structural Organization ◽  
Chromosomal Assignment ◽  
Heparin Binding ◽  
Gene Encoding ◽  
Diphtheria Toxin Receptor ◽  
Toxin Receptor ◽  
Epidermal Growth

A Diphtheria Toxin Receptor Deficient in Epidermal Growth Factor–Like Biological Activity

2006 ◽  
Vol 140 (6) ◽  
pp. 831-841 ◽  
Author(s):  
Norihisa Furukawa ◽  
Michiko Saito ◽  
Toshio Hakoshima ◽  
Kenji Kohno
Keyword(s):  
Biological Activity ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Diphtheria Toxin ◽  
Diphtheria Toxin Receptor ◽  
Toxin Receptor ◽  
Epidermal Growth

Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursor

Cell ◽  
1992 ◽  
Vol 69 (6) ◽  
pp. 1051-1061 ◽  
Author(s):  
Joseph G. Naglich ◽  
James E. Metherall ◽  
David W. Russell ◽  
Leon Eidels
Keyword(s):  
Growth Factor ◽  
Diphtheria Toxin ◽  
Expression Cloning ◽  
Heparin Binding ◽  
Diphtheria Toxin Receptor ◽  
Toxin Receptor

scholarly journals Tissue distribution of mRNA for heparin-binding epidermal growth factor

1992 ◽  
Vol 287 (3) ◽  
pp. 681-684 ◽  
Author(s):  
T J Vaughan ◽  
J C Pascall ◽  
K D Brown
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Diphtheria Toxin ◽  
Cell Surface Receptor ◽  
Heparin Binding ◽  
Reverse Transcription Pcr ◽  
Body Tissues ◽  
Wide Range ◽  
Surface Receptor ◽  
Epidermal Growth

Heparin-binding epidermal growth factor (HB-EGF) is a recently identified member of the EGF family. Mature HB-EGF is processed from a larger transmembrane precursor which can itself act as a cell-surface receptor for the internalization of diphtheria toxin into eukaryotic cells. However, to date there is no information available on the distribution of HB-EGF in mammalian tissues. We have therefore used reverse-transcription PCR to analyse the expression of HB-EGF mRNA in a wide range of tissues. HB-EGF transcripts were detected in RNA isolated from 15 of the 22 tissues obtained from adult pigs, which is consistent with the ability of diphtheria toxin to affect many body tissues.

Characterization of the gene encoding murine heparin-binding epidermal growth factor-like growth factor

Gene ◽  
1996 ◽  
Vol 169 (2) ◽  
pp. 291-292 ◽  
Author(s):  
Paul A. Harding ◽  
David R. Brigstock ◽  
Liming Shen ◽  
Melissa A. Crissman-Combs ◽  
Gail E. Besner
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Heparin Binding ◽  
Gene Encoding ◽  
Epidermal Growth
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