Influence of protein surface charge on the bimolecular kinetics of a potassium channel peptide inhibitor

Biochemistry ◽  
1993 ◽  
Vol 32 (27) ◽  
pp. 6982-6987 ◽  
Author(s):  
Laura Escobar ◽  
Michael J. Root ◽  
Roderick MacKinnon
Keyword(s):  
Potassium Channel ◽  
Surface Charge ◽  
Peptide Inhibitor ◽  
Protein Surface ◽  
Kinetics Of

scholarly journals Improving Trafficking and Kinetics of a Synthetic Light-Gated Potassium Channel

2017 ◽  
Vol 112 (3) ◽  
pp. 172a-173a
Author(s):  
Laura S. Alberio ◽  
Giordano Defranceschi ◽  
Federica Simeoni ◽  
Paolo Zuccolini ◽  
Gerhard Thiel ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Kinetics Of

Slow kinetics of a potassium channel inAcetabularia

1988 ◽  
Vol 102 (2) ◽  
pp. 141-152 ◽  
Author(s):  
A. Bertl ◽  
H. G. Klieber ◽  
D. Gradmann
Keyword(s):  
Potassium Channel ◽  
Slow Kinetics ◽  
Kinetics Of

scholarly journals Cloning and Expression of the Human Kv4.3 Potassium Channel

1999 ◽  
Vol 81 (4) ◽  
pp. 1974-1977 ◽  
Author(s):  
Daniel Dilks ◽  
Huai-Ping Ling ◽  
Mark Cockett ◽  
Patricia Sokol ◽  
Randy Numann
Keyword(s):  
Potassium Channel ◽  
Cloning And Expression ◽  
Short Version ◽  
Rt Pcr ◽  
Amino Acid Deletion ◽  
Inactivation Curve ◽  
Recovery From Inactivation ◽  
Window Current ◽  
Kinetics Of ◽  
The Brain

Cloning and expression of the human Kv4.3 potassium channel. We report on the cloning and expression of hKv4.3, a fast inactivating, transient, A-type potassium channel found in both heart and brain that is 91% homologous to the rat Kv4.3 channel. Two isoforms of hKv4.3 were cloned. One is full length (hKv4.3 long), and the other has a 19 amino acid deletion (hKv4.3 short). RT-PCR shows that the brain contains both forms of the channel RNA, whereas the heart predominantly has the longer version. Both versions of the channel were expressed in Xenopus oocytes, and both contain a significant window or noninactivating current seen near potentials of −30 to −40 mV. The inactivation curve for hKv4.3 short is shifted 10 mV positive relative to hKv4.3 long. This causes the peak window current for the short version to occur near −30 mV and the peak for the longer version to be at −40 mV. There was little difference in the recovery from inactivation or in the kinetics of inactivation between the two isoforms of the channel.

scholarly journals Protein surface topography as a tool to enhance the selective activity of a potassium channel blocker

2019 ◽  
Vol 294 (48) ◽  
pp. 18349-18359 ◽  
Author(s):  
Antonina A. Berkut ◽  
Anton O. Chugunov ◽  
Konstantin S. Mineev ◽  
Steve Peigneur ◽  
Valentin M. Tabakmakher ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Surface Topography ◽  
Channel Blocker ◽  
Protein Surface ◽  
Potassium Channel Blocker ◽  
Selective Activity

Kinetics of Drug Interaction with the Kv11.1 Potassium Channel

2014 ◽  
Vol 85 (5) ◽  
pp. 769-776 ◽  
Author(s):  
Adam P. Hill ◽  
Mark J. Perrin ◽  
Juliane Heide ◽  
Terence J. Campbell ◽  
Stefan A. Mann ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Potassium Channel ◽  
Kinetics Of

scholarly journals Kinetics of Enzyme Attack on Substrates Covalently Attached to Solid Surfaces: Influence of Spacer Chain Length, Immobilized Substrate Surface Concentration and Surface Charge

Langmuir ◽  
2008 ◽  
Vol 24 (20) ◽  
pp. 11762-11769 ◽  
Author(s):  
Joseph Deere ◽  
Rui F. De Oliveira ◽  
Bartłomiej Tomaszewski ◽  
Sarah Millar ◽  
Antonia Lalaouni ◽  
...  
Keyword(s):  
Surface Charge ◽  
Chain Length ◽  
Substrate Surface ◽  
Surface Concentration ◽  
Solid Surfaces ◽  
Spacer Chain Length ◽  
Immobilized Substrate ◽  
Kinetics Of

Progress in Characterization of Sludge Particles

1993 ◽  
Vol 28 (1) ◽  
pp. 145-148 ◽  
Author(s):  
E. Friedrich ◽  
H. Friedrich ◽  
W. Heinze ◽  
K. Jobst ◽  
H.-J. Richter ◽  
...  
Keyword(s):  
Surface Charge ◽  
Size Distribution ◽  
Sewage Treatment ◽  
Sewage Treatment Plant ◽  
Treatment Plant ◽  
Degradation Process ◽  
Laser Diffraction ◽  
Kinetics Of Degradation ◽  
Kinetics Of

The studies aimed at examining the influences of the particle size distribution and surface charge on the behaviour of sludge in dewatering. It was possible to show that defined size dispersions of sludge particles as well as surface charge are necessary to reach better dewatering results and that the found correlations were independent of the type of sludge and the sewage treatment plant (Friedrich et al., 1990 and 1991). Based on laser diffraction measurements to determine panicle size distribution it was found that it was necessary to set a specific proportion between fine and large sludge particles in order to produce the best possible dewatering results and to get the required shear resistant flocs. To characterize the surface charge of the sludge particles various measuring methods were used. Determining the zeta-potential is a suitable means to describe the kinetics of degradation process in the sludge.

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