Some characteristics of DNA strand scission by macromolecular antitumor antibiotic C-1027 containing a novel enediyne chromophore

Biochemistry ◽  
1993 ◽  
Vol 32 (21) ◽  
pp. 5548-5553 ◽  
Author(s):  
Yukio Sugiura ◽  
Takuyuki Matsumoto
Keyword(s):  
Antitumor Antibiotic ◽  
Strand Scission ◽  
Dna Strand

DNA strand scission by the novel antitumor antibiotic leinamycin

Biochemistry ◽  
1990 ◽  
Vol 29 (24) ◽  
pp. 5676-5681 ◽  
Author(s):  
Mitsunobu Hara ◽  
Yutaka Saitoh ◽  
Hirofumi Nakano
Keyword(s):  
Antitumor Antibiotic ◽  
The Novel ◽  
Strand Scission ◽  
Dna Strand

Direct photo-induced DNA strand scission by a ruthenium bipyridyl complex

2004 ◽  
Vol 98 (11) ◽  
pp. 1750-1756 ◽  
Author(s):  
Eylon Yavin ◽  
Eric D.A. Stemp ◽  
Lev Weiner ◽  
Irit Sagi ◽  
Rina Arad-Yellin ◽  
...  
Keyword(s):  
Strand Scission ◽  
Dna Strand ◽  
Bipyridyl Complex ◽  
Ruthenium Bipyridyl

Urushiol components as mediators in DNA strand scission

1990 ◽  
Vol 46 (5) ◽  
pp. 500-502 ◽  
Author(s):  
Ch. Wasser ◽  
F. Silva ◽  
E. Rodriguez
Keyword(s):  
Strand Scission ◽  
Dna Strand

scholarly journals DNA strand scission induced by a non-thermal atmospheric pressure plasma jet

2010 ◽  
Vol 12 (28) ◽  
pp. 7779 ◽  
Author(s):  
Sylwia Ptasińska ◽  
Blagovest Bahnev ◽  
Agnieszka Stypczyńska ◽  
Mark Bowden ◽  
Nigel J. Mason ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Atmospheric Pressure Plasma ◽  
Plasma Jet ◽  
Atmospheric Pressure Plasma Jet ◽  
Strand Scission ◽  
Pressure Plasma ◽  
Dna Strand

Studies related to antitumor antibiotics. Part VII. Synthesis of streptonigrin analogues and their single strand scission of DNA

1976 ◽  
Vol 54 (16) ◽  
pp. 2563-2572 ◽  
Author(s):  
J. William Lown ◽  
Soo-Khoon Sim
Keyword(s):  
Antitumor Activity ◽  
Dna Cleavage ◽  
Single Strand ◽  
Antitumor Antibiotic ◽  
Antitumor Antibiotics ◽  
Substitution Pattern ◽  
Circular Dna ◽  
Strand Scission ◽  
Independent Synthesis ◽  
Selective Catalysis

The syntheses of a group of 2-(o-nitrophenyl)- and 2-(o-aminophenyl)-5,8-quinolinediones which are structurally related to the antitumor antibiotic streptonigrin are described. Ambiguities in the position of required nucleophilic displacements are resolved by independent synthesis. The rates of single strand cleavage of PM2 ccc-DNA (covalently-closed circular-DNA) induced by these compounds are compared, which correlates with antitumor activity. The 2-(o-nitrophenyl) derivatives give consistently more rapid DNA cleavage than the 2-(o-aminophenyl) compounds. The autoxidations of the dihydroxyquinolines are subject to selective catalysis by Cu2+ on. 2-(o-Aminophenyl)-7-amino-6-methoxy-5,6-quinolinedione which has a substitution pattern most closely resembling streptonigrin also closely parallels the rate of scission of DNA of the latter in the presence of NADPH.

DNA strand scission by naturally occurring 5-alkylresorcinols

1988 ◽  
Vol 110 (11) ◽  
pp. 3650-3651 ◽  
Author(s):  
Ralph T. Scannell ◽  
John R. Barr ◽  
V. S. Murty ◽  
K. Sambi. Reddy ◽  
Sidney M. Hecht
Keyword(s):  
Strand Scission ◽  
Naturally Occurring ◽  
Dna Strand
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