Large activation energy barriers to chaperone-peptide complex formation and dissociation

Biochemistry ◽  
1995 ◽  
Vol 34 (47) ◽  
pp. 15574-15582 ◽  
Author(s):  
Carol D. Farr ◽  
Floyd J. Galiano ◽  
Stephan N. Witt
Keyword(s):  
Activation Energy ◽  
Complex Formation ◽  
Energy Barriers ◽  
Peptide Complex

Insights into the synergistic role of metal–lattice oxygen site pairs in four-centered C–H bond activation of methane: the case of CuO

2016 ◽  
Vol 6 (11) ◽  
pp. 3984-3996 ◽  
Author(s):  
Jithin John Varghese ◽  
Quang Thang Trinh ◽  
Samir H. Mushrif
Keyword(s):  
Activation Energy ◽  
Copper Oxide ◽  
Bond Activation ◽  
Lattice Oxygen ◽  
Oxide Surfaces ◽  
Energy Barriers ◽  
Metal Lattice ◽  
Oxygen Site ◽  
Site Pair

Of the three mechanisms for activation of methane on copper and copper oxide surfaces, the under-coordinated Cu–O site pair mediated mechanism on CuO surfaces has the lowest activation energy barriers.

scholarly journals Effect of intercalator and Lewis acid–base branched peptide complex formation: boosting affinity towards HIV-1 RRE RNA

MedChemComm ◽  
2016 ◽  
Vol 7 (7) ◽  
pp. 1436-1440 ◽  
Author(s):  
Jessica E. Wynn ◽  
Wenyu Zhang ◽  
Denis M. Tebit ◽  
Laurie R. Gray ◽  
Marie-Louise Hammarskjold ◽  
...  
Keyword(s):  
Complex Formation ◽  
Lewis Acid ◽  
Boronic Acid ◽  
Peptide Library ◽  
Acid Base ◽  
Peptide Complex ◽  
Hiv 1

Screening of a boronic acid and acridine containing branched peptide library revealed compounds that bind HIV-1 RRE RNA and inhibit HIV-1 replication.

scholarly journals Optical Absorption, Kinetics and Thermodynamic Studies of Pr(III) and Nd(III) Ions with N-Acetyl L-Cysteine in Presence of Ca(II) ions

2022 ◽  
Vol 34 (2) ◽  
pp. 272-278
Author(s):  
Thiyam Samrat Singh ◽  
Thiyam David Singh
Keyword(s):  
Activation Energy ◽  
Complex Formation ◽  
Optical Absorption ◽  
Spectroscopic Technique ◽  
Absorption Kinetics ◽  
Intensity Parameter ◽  
Hypersensitive Transition ◽  
Heterobimetallic Complex ◽  
Spectral Bands ◽  
Kinetics And Thermodynamic

Interaction of N-acetyl-L-cysteine (NAC) with Pr3+ (Pr(NO3)3·6H2O) and Nd3+ (Nd(NO3)3·6H2O) ions are studied in presence of Ca2+ (Ca(NO3)3·4H2O) ion in an aqueous and organic solvent by applying the spectroscopic technique for quantitative probe of 4f-4f transition. The complexation was determined by the variation in the intensities of 4f-4f absorption spectral bands and by applying the change of symmetric properties of electronic-dipole known as Judd-Ofelt parameters Tλ (λ = 2,4,6). On the addition of Ca2+ ion in the binary complexation of praseodymium and neodymium with N-acetyl-L-cysteine (NAC) there is an intensification of bands which shows the effect of Ca2+ toward the heterobimetallic complex formation. Other parameters like Slater-Condon (Fk), bonding (b1/2), the Nephelauxetic ratio (β), percentage covalency (δ) are also used to correlate the complexation of metals with N-acetyl-L-cysteine (NAC). With the minor change in coordination around Pr3+ and Nd3+ ions, the sensitivity of 4f-4f bands is detected and further used to explain the coordination of N-acetyl-L-cysteine (NAC) with Pr3+ and Nd3+ in presence of Ca2+. The variation in oscillator strength (Pobs), energy (Eobs) and dipole intensity parameter help in supporting the heterobimetallic complexation of N-acetyl-L-cysteine. In kinetics investigation, the rate of the complexation of both hypersensitive and pseudo-hypersensitive transition is evaluated at various temperature in DMF solvent. The value of the thermodynamic parameters such as ΔHo, ΔSo and ΔGo and activation energy (Ea) also evaluated.

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