pH Dependence of Ligand Binding to D2 Dopamine Receptors

Biochemistry ◽  
1995 ◽  
Vol 34 (41) ◽  
pp. 13635-13641 ◽  
Author(s):  
Ursula M. D'Souza ◽  
Philip G. Strange
Keyword(s):  
Ligand Binding ◽  
Dopamine Receptors ◽  
Ph Dependence ◽  
D2 Dopamine Receptors

D2 dopamine receptors in rat striatum are homogeneous as revealed by ligand-binding studies

1988 ◽  
Vol 37 (22) ◽  
pp. 4335-4339 ◽  
Author(s):  
M.N. Leonard ◽  
C.A. Halliday ◽  
A.S. Marriott ◽  
P.G. Strange
Keyword(s):  
Ligand Binding ◽  
Dopamine Receptors ◽  
Rat Striatum ◽  
Binding Studies ◽  
D2 Dopamine Receptors

Theoretical study of 3-D molecular similarity and ligand binding modes of orthologous human and rat D2 dopamine receptors

2011 ◽  
Vol 41 (7) ◽  
pp. 537-545 ◽  
Author(s):  
Marvin A. Soriano-Ursúa ◽  
Jorge O. Ocampo-López ◽  
Karina Ocampo-Mendoza ◽  
José G. Trujillo-Ferrara ◽  
José Correa-Basurto
Keyword(s):  
Ligand Binding ◽  
Dopamine Receptors ◽  
Theoretical Study ◽  
Molecular Similarity ◽  
Binding Modes ◽  
D2 Dopamine Receptors

scholarly journals ALTERED LIGAND BINDING BY D1 AND D2 DOPAMINE RECEPTORS IN RESPONSE TO HYPOXIA AND POSTHYPOXIC RECOVERY. ▴ 1376

1996 ◽  
Vol 39 ◽  
pp. 232-232
Author(s):  
Stephanie J Murphy ◽  
Thomas Liu ◽  
Michaela Windfuhr ◽  
Dekun Song ◽  
Anna Pastuszko
Keyword(s):  
Ligand Binding ◽  
Dopamine Receptors ◽  
D2 Dopamine Receptors

scholarly journals Importance of thiol groups in ligand binding to D2 dopamine receptors from brain and anterior pituitary gland

1992 ◽  
Vol 281 (2) ◽  
pp. 377-380 ◽  
Author(s):  
P L Chazot ◽  
P G Strange
Keyword(s):  
Ligand Binding ◽  
Pituitary Gland ◽  
Dopamine Receptors ◽  
Dopamine Receptor ◽  
Thiol Group ◽  
Brain Regions ◽  
Subsequent Treatment ◽  
D2 Dopamine Receptor ◽  
Receptor Binding Site ◽  
D2 Dopamine Receptors

The effects of the thiol group reagent 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB) on D2 dopamine receptors have been examined in three brain regions (caudate nucleus, putamen and olfactory tubercle), and in the anterior and neurointermediate lobes of the pituitary gland. Whereas the receptors in brain were insensitive to DTNB, a dose-dependent inhibition of [3H]spiperone binding to D2 receptors in both lobes of the pituitary gland was observed. The effects in the pituitary could be reversed by subsequent treatment with dithiothreitol and could be prevented by prior occupancy of the receptor binding site with a ligand. The effect of DTNB was to decrease the number of ligand-binding sites without altering the affinity of those remaining. The results show that modification of a thiol group of the D2 dopamine receptor in the two lobes of the pituitary gland tested here significantly affects ligand binding. There is therefore a difference between the D2 dopamine receptor populations in brain and pituitary in their sensitivity to modification by DTNB, and this may imply the existence of different receptor isoforms in the two issues.

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