The Tissue-Specific Nuclear Matrix Protein, NMP-2, Is a Member of the AML/PEBP2/Runt Domain Transcription Factor Family: Interactions with the Osteocalcin Gene Promoter

Biochemistry ◽  
1995 ◽  
Vol 34 (40) ◽  
pp. 13125-13132 ◽  
Author(s):  
Harold L. Merriman ◽  
Andre J. van Wijnen ◽  
Scott Hiebert ◽  
Joseph P. Bidwell ◽  
Edward Fey ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Nuclear Matrix ◽  
Matrix Protein ◽  
Gene Promoter ◽  
Family Interactions ◽  
Runt Domain ◽  
Transcription Factor Family ◽  
Nuclear Matrix Protein ◽  
Tissue Specific ◽  
Osteocalcin Gene

scholarly journals The nuclear matrix protein NMP-1 is the transcription factor YY1.

1995 ◽  
Vol 92 (23) ◽  
pp. 10526-10530 ◽  
Author(s):  
B. Guo ◽  
P. R. Odgren ◽  
A. J. van Wijnen ◽  
T. J. Last ◽  
J. Nickerson ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Nuclear Matrix ◽  
Matrix Protein ◽  
Nuclear Matrix Protein ◽  
Transcription Factor Yy1

scholarly journals Osteocalcin gene promoter-binding factors are tissue-specific nuclear matrix components.

1993 ◽  
Vol 90 (8) ◽  
pp. 3162-3166 ◽  
Author(s):  
J. P. Bidwell ◽  
A. J. Van Wijnen ◽  
E. G. Fey ◽  
S. Dworetzky ◽  
S. Penman ◽  
...  
Keyword(s):  
Nuclear Matrix ◽  
Gene Promoter ◽  
Tissue Specific ◽  
Osteocalcin Gene ◽  
Matrix Components

984: Variability in the Performance of Nuclear Matrix Protein 22 in the Detection of Bladder Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 317-317
Author(s):  
Shahrokh F. Shariat ◽  
Michael Marberger ◽  
Yair Lotan ◽  
Marta Sanchez-Carbayo ◽  
Craig D. Zippe ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Nuclear Matrix ◽  
Matrix Protein ◽  
Nuclear Matrix Protein

Sa1664 Identification of Nuclear Matrix Protein Alternations Associated With Autophagic Dysfunction in the Liver

2016 ◽  
Vol 150 (4) ◽  
pp. S1090
Author(s):  
Shunhei Yamashina ◽  
Kousuke Izumi ◽  
Yoshihiro Inami ◽  
Tomonori Aoyama ◽  
Akira Uchiyama ◽  
...  
Keyword(s):  
Nuclear Matrix ◽  
Matrix Protein ◽  
Nuclear Matrix Protein

hNMP 200: A Novel Human Common Nuclear Matrix Protein Combining Structural and Regulatory Functions

2000 ◽  
Vol 261 (1) ◽  
pp. 166-179 ◽  
Author(s):  
Josef Gotzmann ◽  
Christopher Gerner ◽  
Michael Meissner ◽  
Klaus Holzmann ◽  
Rudolf Grimm ◽  
...  
Keyword(s):  
Nuclear Matrix ◽  
Matrix Protein ◽  
Nuclear Matrix Protein ◽  
Regulatory Functions

scholarly journals The Nuclear Matrix Protein CDP Represses Hepatic Transcription of the Human Cholesterol-7α Hydroxylase Gene

2000 ◽  
Vol 275 (34) ◽  
pp. 26649-26660 ◽  
Author(s):  
Travis J. Antes ◽  
Jean Chen ◽  
Allen D. Cooper ◽  
Beatriz Levy-Wilson
Keyword(s):  
Nuclear Matrix ◽  
Matrix Protein ◽  
Nuclear Matrix Protein ◽  
Hydroxylase Gene

Diagnostic accuracy of NMP-52, NMP-22 and urine cytology in the diagnosis of bladder cancer

2021 ◽  
Vol 16 (10) ◽  
pp. 59-62
Author(s):  
Mohamed J. Saadh
Keyword(s):  
Bladder Cancer ◽  
Nuclear Matrix ◽  
Diagnostic Performance ◽  
Matrix Protein ◽  
Urinary Cytology ◽  
Significant Relation ◽  
Nuclear Matrix Protein ◽  
Diagnostic Efficacy ◽  
Noninvasive Biomarkers ◽  
New Biomarkers

Bladder cancer (BC) is the most important tumor problem of urologic cancer. Therefore, noninvasive urinary biomarkers were used for diagnosis of BC. However, the new biomarkers failed to reach higher accuracy. The aim of this study was to assess the diagnostic efficacy of nuclear matrix protein-22 (NMP- 22), nuclear matrix protein-52 (NMP-52), urinary cytology and to investigate combinations of urine NMP-52 with urinary cytology as noninvasive biomarkers to increase diagnostic performance of bladder cancer at different grades and stages. Overall, there were 156 subjects (62 BC, 54 cystitis patients and 40 healthy volunteers). The NMP-22 and NMP-52 were quantified in urine samples by ELISA. The urinary cytology is used by some physicians routinely for diagnosis of BC. The sensitivity and specificity for NMP-52 were 94% and 82%, for NMP-22 69% and 80.8% and for cytology 56% and 94.6% respectively and also, both urinary NMP-22 and NMP-52 have extremely significant relation (p<0.0001) to BC vs. healthy individuals and cystitis patients. Moreover, the combination of NMP- 52 with urinary cytology could predict all BC stages and grade with 95.6% sensitivity and 94.3% specificity. In conclusion, NMP-52 and urinary cytology in combination improve diagnostic performance for BC detection in different pathological types.

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