Role of Binding Energy with Coenzyme A in Catalysis by 3-Oxoacid Coenzyme A Transferase

Biochemistry ◽  
1995 ◽  
Vol 34 (37) ◽  
pp. 11678-11689 ◽  
Author(s):  
Adrian Whitty ◽  
Carol A. Fierke ◽  
William P. Jencks
Keyword(s):  
Binding Energy ◽  
Coenzyme A

Role of relativistic and binding-energy effects in the Pb K-shell ionisation by Cl projectiles

1981 ◽  
Vol 87 (1-2) ◽  
pp. 24-26 ◽  
Author(s):  
K.E. Stiebing ◽  
I. Tserruya ◽  
K. Bethge ◽  
H. Schmidt-Böcking
Keyword(s):  
Binding Energy

scholarly journals An essential role of acetyl coenzyme A in the catalytic cycle of insect arylalkylamine N-acetyltransferase

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Chu-Ya Wu ◽  
I-Chen Hu ◽  
Yi-Chen Yang ◽  
Wei-Cheng Ding ◽  
Chih-Hsuan Lai ◽  
...  
Keyword(s):  
Essential Role ◽  
Coenzyme A ◽  
Catalytic Cycle ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme

Genetic studies of the role of fatty acid and coenzyme A in photocatalytic inactivation of Escherichia coli

2012 ◽  
Vol 46 (13) ◽  
pp. 3951-3957 ◽  
Author(s):  
Minghui Gao ◽  
Taicheng An ◽  
Guiying Li ◽  
Xin Nie ◽  
Ho-Yin Yip ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Fatty Acid ◽  
Coenzyme A ◽  
Genetic Studies ◽  
Photocatalytic Inactivation

Signalling functions of coenzyme A and its derivatives in mammalian cells

2014 ◽  
Vol 42 (4) ◽  
pp. 1056-1062 ◽  
Author(s):  
Hongorzul Davaapil ◽  
Yugo Tsuchiya ◽  
Ivan Gout
Keyword(s):  
Mammalian Cells ◽  
Coenzyme A ◽  
Current Knowledge ◽  
Pantothenic Acid ◽  
Future Developments ◽  
Malonyl Coa ◽  
Vitamin B5 ◽  
Coa Thioesters ◽  
Living Organisms

In all living organisms, CoA (coenzyme A) is synthesized in a highly conserved process that requires pantothenic acid (vitamin B5), cysteine and ATP. CoA is uniquely designed to function as an acyl group carrier and a carbonyl-activating group in diverse biochemical reactions. The role of CoA and its thioester derivatives, including acetyl-CoA, malonyl-CoA and HMG-CoA (3-hydroxy-3-methylglutaryl-CoA), in the regulation of cellular metabolism has been extensively studied and documented. The main purpose of the present review is to summarize current knowledge on extracellular and intracellular signalling functions of CoA/CoA thioesters and to speculate on future developments in this area of research.

scholarly journals Structural and Dynamic Characterizations Highlight the Deleterious Role of SULT1A1 R213H Polymorphism in Substrate Binding

2019 ◽  
Vol 20 (24) ◽  
pp. 6256 ◽  
Author(s):  
Raju Dash ◽  
Md. Chayan Ali ◽  
Nayan Dash ◽  
Md. Abul Kalam Azad ◽  
S. M. Zahid Hosen ◽  
...  
Keyword(s):  
Binding Energy ◽  
Cancer Progression ◽  
Conformational Changes ◽  
Substrate Binding ◽  
Dynamics Simulation ◽  
Loss Of Function ◽  
Functional Consequences ◽  
Binding Energy Analysis ◽  
Exogenous Compounds

Sulfotransferase 1A1 (SULT1A1) is responsible for catalyzing various types of endogenous and exogenous compounds. Accumulating data indicates that the polymorphism rs9282861 (R213H) is responsible for inefficient enzymatic activity and associated with cancer progression. To characterize the detailed functional consequences of this mutation behind the loss-of-function of SULT1A1, the present study deployed molecular dynamics simulation to get insights into changes in the conformation and binding energy. The dynamics scenario of SULT1A1 in both wild and mutated types as well as with and without ligand showed that R213H induced local conformational changes, especially in the substrate-binding loop rather than impairing overall stability of the protein structure. The higher conformational changes were observed in the loop3 (residues, 235–263), turning loop conformation to A-helix and B-bridge, which ultimately disrupted the plasticity of the active site. This alteration reduced the binding site volume and hydrophobicity to decrease the binding affinity of the enzyme to substrates, which was highlighted by the MM-PBSA binding energy analysis. These findings highlight the key insights of structural consequences caused by R213H mutation, which would enrich the understanding regarding the role of SULT1A1 mutation in cancer development and also xenobiotics management to individuals in the different treatment stages.

Sign in / Sign up

Export Citation Format

Share Document