Mechanism of Free Radical-Induced Hemolysis of Human Erythrocytes: Hemolysis by Water-Soluble Radical Initiator

Biochemistry ◽  
1995 ◽  
Vol 34 (28) ◽  
pp. 8940-8949 ◽  
Author(s):  
Yukio Sato ◽  
Shinya Kamo ◽  
Takeo Takahashi ◽  
Yasuo Suzuki
Keyword(s):  
Free Radical ◽  
Human Erythrocytes ◽  
Water Soluble ◽  
Radical Initiator

scholarly journals A Theoretical Antioxidant Mechanism for Cytoprotective Effect of p-AcetamideSalicylate Derivatives against Free Radical Initiator AAPH in Human Erythrocytes

2021 ◽  
Author(s):  
Valéria Barros ◽  
Glaécia Pereira ◽  
Sirlene Ota ◽  
Fernanda Melo ◽  
Ana Carolina de Jesus ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Free Radical ◽  
Molecular Mechanism ◽  
Positive Control ◽  
Human Erythrocytes ◽  
Water Soluble ◽  
Cytoprotective Effect ◽  
Potent Effect ◽  
Radical Initiator ◽  
Free Radical Initiator

The molecular mechanism of cytoprotective effect on human erythrocytes of aminophenol and salicylates associated derivatives was related to their antioxidant capacity. The oxidative hemolysis induced by water-soluble free-radical initiator 2,2’-azobis-(2-amidine-propane)-dihydrochloride (AAPH) was inhibited by drug candidates named benzaminophen (BZL), salicytamide or 5-acetamide-salicylic acid (ASL), and salibenzamide or 5-benzamide-salicylic acid (BSL) when compared to their parents salicylic acid (SAC) and acetaminophen (ACP). Trolox (TLX) was the most powerful compound and used as positive control. BZL showed a potent effect followed by ACP > BSL > ASL. SAC did not show protective effect in any evaluated concentrations. These results are in accordance with the molecular mechanism by using theoretical calculation of single electron transfers (SET), hydrogen atom transfers (HAT), and sequential proton loss electron transfer (SPLET) by means of DFT/B3LYP/6-31++G(d,p) level of theory. [1,5] Hydrogen shift between carboxyl and phenol moieties and electronic properties related to pKa and other physicalchemical properties can be involved. The molecular association approach provides protective compounds more effective than SAC.

scholarly journals Mechanism of Free Radical-Induced Hemolysis of Human Erythrocytes. II. Hemolysis by Lipid-Soluble Radical Initiator.

1998 ◽  
Vol 21 (3) ◽  
pp. 250-256 ◽  
Author(s):  
Yukio SATO ◽  
Sachiko KANAZAWA ◽  
Keiko SATO ◽  
Yasuo SUZUKI
Keyword(s):  
Free Radical ◽  
Human Erythrocytes ◽  
Radical Initiator

scholarly journals Effect of Oxygen and Initiator Solubility on Admicellar Polymerization of Styrene on Silica Surfaces

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Pohlee Cheah ◽  
Caitlin N. Bhikha ◽  
John H. O’Haver ◽  
Adam E. Smith
Keyword(s):  
Molecular Weight ◽  
Free Radical ◽  
Emulsion Polymerization ◽  
Water Soluble ◽  
Polymer Yield ◽  
Radical Initiator ◽  
Admicellar Polymerization ◽  
Molecular Weights ◽  
Precipitated Silica ◽  
Free Radical Initiator

Although admicellar polymerization has been termed the surface analog of emulsion polymerization, previous reports utilizing free radical-initiated admicellar polymerization relied on high levels of the free radical initiator when compared to emulsion polymerization, likely due to the presence of oxygen in the reported admicellar polymerization systems. Admicellar polymerizations of styrene on the surface of precipitated silica initiated by either a water-soluble or a water-insoluble initiator were studied to determine the effect of dissolved oxygen and free radical initiator solubility on the kinetics, yield, and molecular weight of the polymer formed. Results show that the presence of oxygen reduces the polymer yield and limits molecular weight. The solubility of the initiator also affected the polymer formed in the admicellar polymerization of styrene. While monomer conversions and polymer yield were similar, the molecular weights of polymerizations initiated by a water-soluble initiator were higher than comparable polymerizations initiated by a water-insoluble initiator.

Antioxidant Capacities of Water-Soluble Substances Extracted from JinHua Ham

2014 ◽  
Vol 675-677 ◽  
pp. 1654-1657
Author(s):  
Xiao Li Zhou ◽  
Xu Chen ◽  
Ting Feng Hao ◽  
Yi Ming Zhou ◽  
Ying Xiao
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Antioxidant Capacity ◽  
Mass Fraction ◽  
Water Soluble ◽  
Oxidation Capacity ◽  
Hydroxyl Free Radical ◽  
Antioxidant Capacities ◽  
Dpph Scavenging ◽  
Jinhua Ham

This study was designed to evaluate the antioxidant activity of samples extracted from Jinhua ham by using such chemical assays as DPPH, scavenging hydroxyl free radical and ABTS. The results demonstrate that antioxidant capacity of the extracted sample is lower than oxidation capacity of Vc. The IC50 spot of samples ranges between 0.6 % and 2.5 % (mass fraction of solute).

PNIPAM-based graft copolymers prepared using potassium persulfate as free-radical initiator: synthesis reproducibility

2016 ◽  
Vol 294 (6) ◽  
pp. 981-991 ◽  
Author(s):  
Nívia N. Marques ◽  
Bruna V. Lima ◽  
Valdelice R. Silveira ◽  
Bruna L. B. Lima ◽  
Ana M. S. Maia ◽  
...  
Keyword(s):  
Free Radical ◽  
Graft Copolymers ◽  
Potassium Persulfate ◽  
Radical Initiator ◽  
Free Radical Initiator

Polymerization of Diphenylbutadiyne Derivatives in Solution by Free Radical Initiator

2007 ◽  
Vol 44 (6) ◽  
pp. 605-611 ◽  
Author(s):  
Miriam F. Beristain ◽  
Eduardo Muñoz ◽  
Takeshi Ogawa
Keyword(s):  
Free Radical ◽  
Radical Initiator ◽  
Free Radical Initiator

Antioxidant properties of merlot wines in water soluble and lipid soluble free radical generating systems

2000 ◽  
Vol 151 (1) ◽  
pp. 309
Author(s):  
R.S. Faustino ◽  
S. Sobrattee ◽  
T.A. Clark ◽  
G.N. Pierce
Keyword(s):  
Free Radical ◽  
Antioxidant Properties ◽  
Water Soluble
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