Glutamate 139 of the Large .alpha.-Subunit Is the Catalytic Base in the Dehydration of Both D- and L-3-Hydroxyacyl-Coenzyme A But Not in the Isomerization of .DELTA.3,.DELTA.2-Enoyl-Coenzyme A Catalyzed by the Multienzyme Complex of Fatty Acid Oxidation from Escherichia coli

Song-Yu Yang; Xue-Ying He; Horst Schulz

doi:10.1021/bi00019a025

Glutamate 139 of the Large .alpha.-Subunit Is the Catalytic Base in the Dehydration of Both D- and L-3-Hydroxyacyl-Coenzyme A But Not in the Isomerization of .DELTA.3,.DELTA.2-Enoyl-Coenzyme A Catalyzed by the Multienzyme Complex of Fatty Acid Oxidation from Escherichia coli

Biochemistry ◽

10.1021/bi00019a025 ◽

1995 ◽

Vol 34 (19) ◽

pp. 6441-6447 ◽

Cited By ~ 12

Author(s):

Song-Yu Yang ◽

Xue-Ying He ◽

Horst Schulz

Keyword(s):

Escherichia Coli ◽

Fatty Acid ◽

Fatty Acid Oxidation ◽

Coenzyme A ◽

Alpha Subunit ◽

Acid Oxidation ◽

Multienzyme Complex

Download Full-text

Epimerization of 3-hydroxy-4-trans-decenoyl coenzyme A by a dehydration/hydration mechanism catalyzed by the multienzyme complex of fatty acid oxidation from Escherichia coli.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)54369-6 ◽

1991 ◽

Vol 266 (35) ◽

pp. 23904-23908

Author(s):

T.E. Smeland ◽

D. Cuebas ◽

H. Schulz

Keyword(s):

Escherichia Coli ◽

Fatty Acid ◽

Fatty Acid Oxidation ◽

Coenzyme A ◽

Acid Oxidation ◽

Multienzyme Complex ◽

Hydration Mechanism

Download Full-text

The structure of the multienzyme complex of fatty acid oxidation from Escherichia coli.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)69542-6 ◽

1981 ◽

Vol 256 (8) ◽

pp. 3894-3899

Author(s):

S. Pawar ◽

H. Schulz

Keyword(s):

Escherichia Coli ◽

Fatty Acid ◽

Fatty Acid Oxidation ◽

Acid Oxidation ◽

Multienzyme Complex

Download Full-text

Five different enzymatic activities are associated with the multienzyme complex of fatty acid oxidation from Escherichia coli.

Journal of Bacteriology ◽

10.1128/jb.137.1.469-473.1979 ◽

1979 ◽

Vol 137 (1) ◽

pp. 469-473 ◽

Cited By ~ 41

Author(s):

A Pramanik ◽

S Pawar ◽

E Antonian ◽

H Schulz

Keyword(s):

Escherichia Coli ◽

Fatty Acid ◽

Fatty Acid Oxidation ◽

Enzymatic Activities ◽

Acid Oxidation ◽

Multienzyme Complex

Download Full-text

Multienzyme complexes of fatty acid oxidation from escherichia coli K-12 and from a mutant with a defective l-3-hydroxyacyl coenzyme a dehydrogenase

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism ◽

10.1016/0005-2760(83)90202-3 ◽

1983 ◽

Vol 750 (1) ◽

pp. 41-46 ◽

Cited By ~ 4

Author(s):

Ajay Pramanik ◽

Horst Schulz

Keyword(s):

Escherichia Coli ◽

Fatty Acid ◽

Fatty Acid Oxidation ◽

Coenzyme A ◽

Acid Oxidation ◽

Multienzyme Complexes ◽

K 12

Download Full-text

Association of both enoyl coenzyme A hydratase and 3-hydroxyacyl coenzyme A epimerase with an active site in the amino-terminal domain of the multifunctional fatty acid oxidation protein from Escherichia coli.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)53291-9 ◽

1993 ◽

Vol 268 (9) ◽

pp. 6588-6592

Author(s):

S.Y. Yang ◽

M. Elzinga

Keyword(s):

Escherichia Coli ◽

Fatty Acid ◽

Fatty Acid Oxidation ◽

Active Site ◽

Coenzyme A ◽

Acid Oxidation ◽

Amino Terminal ◽

Terminal Domain ◽

Amino Terminal Domain

Download Full-text

Glutamate-119 of the Large α-Subunit Is the Catalytic Base in the Hydration of 2-trans-Enoyl-Coenzyme A Catalyzed by the Multienzyme Complex of Fatty Acid Oxidation fromEscherichia coli†

Biochemistry ◽

10.1021/bi970901t ◽

1997 ◽

Vol 36 (36) ◽

pp. 11044-11049 ◽

Cited By ~ 13

Author(s):

Xue-Ying He ◽

Song-Yu Yang

Keyword(s):

Fatty Acid ◽

Fatty Acid Oxidation ◽

Coenzyme A ◽

Acid Oxidation ◽

Multienzyme Complex ◽

Α Subunit ◽

Fromescherichia Coli

Download Full-text

Histidine-450 Is the Catalytic Residue ofl-3-Hydroxyacyl Coenzyme A Dehydrogenase Associated with the Large α-Subunit of the Multienzyme Complex of Fatty Acid Oxidation fromEscherichia coli†

Biochemistry ◽

10.1021/bi960374y ◽

1996 ◽

Vol 35 (29) ◽

pp. 9625-9630 ◽

Cited By ~ 22

Author(s):

Xue-Ying He ◽

Song-Yu Yang

Keyword(s):

Fatty Acid ◽

Fatty Acid Oxidation ◽

Coenzyme A ◽

Acid Oxidation ◽

Catalytic Residue ◽

Multienzyme Complex ◽

Α Subunit ◽

Fromescherichia Coli

Download Full-text

Channeling of 3-hydroxy-4-trans-decenoyl coenzyme A on the bifunctional beta-oxidation enzyme from rat liver peroxisomes and on the large subunit of the fatty acid oxidation complex from Escherichia coli.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)66723-7 ◽

1986 ◽

Vol 261 (33) ◽

pp. 15390-15395

Author(s):

S Y Yang ◽

D Cuebas ◽

H Schulz

Keyword(s):

Escherichia Coli ◽

Fatty Acid ◽

Fatty Acid Oxidation ◽

Rat Liver ◽

Coenzyme A ◽

Large Subunit ◽

Acid Oxidation ◽

Beta Oxidation ◽

Liver Peroxisomes ◽

Oxidation Enzyme

Download Full-text

The large subunit of the fatty acid oxidation complex from Escherichia coli is a multifunctional polypeptide. Evidence for the existence of a fatty acid oxidation operon (fad AB) in Escherichia coli.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)44566-2 ◽

1983 ◽

Vol 258 (16) ◽

pp. 9780-9785 ◽

Cited By ~ 13

Author(s):

S Y Yang ◽

H Schulz

Keyword(s):

Escherichia Coli ◽

Fatty Acid ◽

Fatty Acid Oxidation ◽

Large Subunit ◽

Acid Oxidation

Download Full-text

The Antianginal Drug Trimetazidine Shifts Cardiac Energy Metabolism From Fatty Acid Oxidation to Glucose Oxidation by Inhibiting Mitochondrial Long-Chain 3-Ketoacyl Coenzyme A Thiolase

Circulation Research ◽

10.1161/01.res.86.5.580 ◽

2000 ◽

Vol 86 (5) ◽

pp. 580-588 ◽

Cited By ~ 431

Author(s):

Paul F. Kantor ◽

Arnaud Lucien ◽

Raymond Kozak ◽

Gary D. Lopaschuk

Keyword(s):

Fatty Acid ◽

Energy Metabolism ◽

Fatty Acid Oxidation ◽

Glucose Oxidation ◽

Coenzyme A ◽

Acid Oxidation ◽

Cardiac Energy Metabolism ◽

Cardiac Energy ◽

Long Chain

Download Full-text