Sequence-Specific DNA Minor Groove Binders. Design and Synthesis of Netropsin and Distamycin Analogues

1998 ◽  
Vol 9 (5) ◽  
pp. 513-538 ◽  
Author(s):  
Christian Bailly ◽  
Jonathan B. Chaires
Keyword(s):  
Minor Groove ◽  
Dna Minor Groove ◽  
Design And Synthesis ◽  
Minor Groove Binders ◽  
Groove Binders

scholarly journals Application of Cu(I)-catalyzed azide–alkyne cycloaddition for the design and synthesis of sequence specific probes targeting double-stranded DNA

2016 ◽  
Vol 12 ◽  
pp. 1348-1360 ◽  
Author(s):  
Svetlana V Vasilyeva ◽  
Vyacheslav V Filichev ◽  
Alexandre S Boutorine
Keyword(s):  
Minor Groove ◽  
Binding Parameters ◽  
Design And Synthesis ◽  
Minor Groove Binders ◽  
Double Stranded Dna ◽  
Triple Helices ◽  
Gel Shift ◽  
Groove Binders

Efficient protocols based on Cu(I)-catalyzed azide–alkyne cycloaddition were developed for the synthesis of conjugates of pyrrole–imidazole polyamide minor groove binders (MGB) with fluorophores and with triplex-forming oligonucleotides (TFOs). Diverse bifunctional linkers were synthesized and used for the insertion of terminal azides or alkynes into TFOs and MGBs. The formation of stable triple helices by TFO-MGB conjugates was evaluated by gel-shift experiments. The presence of MGB in these conjugates did not affect the binding parameters (affinity and triplex stability) of the parent TFOs.

scholarly journals Fluorescence-Labeled Bis-benzamidines as Fluorogenic DNA Minor-Groove Binders: Photophysics and Binding Dynamics

2014 ◽  
Vol 21 (4) ◽  
pp. 1609-1619 ◽  
Author(s):  
Jorge Bordello ◽  
Mateo I. Sánchez ◽  
M. Eugenio Vázquez ◽  
José L. Mascareñas ◽  
Wajih Al-Soufi ◽  
...  
Keyword(s):  
Minor Groove ◽  
Dna Minor Groove ◽  
Minor Groove Binders ◽  
Groove Binders

DNA minor groove binders as potential antitumor and antimicrobial agents

2004 ◽  
Vol 24 (4) ◽  
pp. 475-528 ◽  
Author(s):  
Pier Giovanni Baraldi ◽  
Andrea Bovero ◽  
Francesca Fruttarolo ◽  
Delia Preti ◽  
Mojgan Aghazadeh Tabrizi ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Minor Groove ◽  
Dna Minor Groove ◽  
Minor Groove Binders ◽  
Groove Binders ◽  
Potential Antitumor

Comparison of Computational Methods to Model DNA Minor Groove Binders

2011 ◽  
Vol 51 (3) ◽  
pp. 558-571 ◽  
Author(s):  
Hemant Kumar Srivastava ◽  
Mukesh Chourasia ◽  
Devesh Kumar ◽  
G. Narahari Sastry
Keyword(s):  
Computational Methods ◽  
Minor Groove ◽  
Dna Minor Groove ◽  
Minor Groove Binders ◽  
Groove Binders

Sugar–Oligoamides: Synthesis of DNA Minor Groove Binders

2012 ◽  
Vol 77 (23) ◽  
pp. 10870-10881 ◽  
Author(s):  
Concepción Badı́a ◽  
Florence Souard ◽  
Cristina Vicent
Keyword(s):  
Minor Groove ◽  
Dna Minor Groove ◽  
Minor Groove Binders ◽  
Groove Binders

scholarly journals 81 A new series of biologically active DNA minor groove binders based on bisbenzimidazole and benzimidazole-pyrrole motives

2013 ◽  
Vol 31 (sup1) ◽  
pp. 52-53 ◽  
Author(s):  
Alexander A. Ivanov ◽  
Olga Yu. Susova ◽  
Victor I. Salyanov ◽  
Kirill I. Kirsanov ◽  
Alexei L. Zhuze
Keyword(s):  
Minor Groove ◽  
Biologically Active ◽  
Dna Minor Groove ◽  
Minor Groove Binders ◽  
Groove Binders
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