DNA Cleavage by an α,3-Dehydrotoluene Precursor Conjugated to a Minor Groove Binding Element†

1996 ◽  
Vol 7 (3) ◽  
pp. 322-331 ◽  
Author(s):  
Andrew G. Myers ◽  
Cynthia A. Parrish
Keyword(s):  
Dna Cleavage ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
A Minor

scholarly journals DNA Minor Groove Binding with Bisbenzamidine-Ru(II) Complexes

2019 ◽  
Author(s):  
Mateo I. Sánchez ◽  
Gustavo Rama ◽  
Renata Calo ◽  
Kübra Ucar ◽  
Per Lincoln ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Coordination Compounds ◽  
Photophysical Properties ◽  
Organic Ligand ◽  
Minor Groove ◽  
The Other ◽  
Minor Groove Binding ◽  
Binding Agent ◽  
Groove Binding ◽  
Dna Minor Groove

We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis‑benzamidine minor groove DNA-binding agent with a ruthenium(II) complex. Importantly, one of the enantiomers (Δ‑[Ru(bpy)<sub>2</sub><b>b4bpy</b>]<sup>2+</sup>, <b>Δ‑4Ru</b>) shows a considerably higher DNA affinity than the parent organic ligand and than the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.

A Minor Groove Binding Copper-Phenanthroline Conjugate Produces Direct Strand Breaks via β-Elimination of 2-Deoxyribonolactone

2002 ◽  
Vol 124 (31) ◽  
pp. 9062-9063 ◽  
Author(s):  
Brian C. Bales ◽  
Marguerite Pitié ◽  
Bernard Meunier ◽  
Marc M. Greenberg
Keyword(s):  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Strand Breaks ◽  
A Minor

Netropsin, a Minor Groove Binding Ligand: A Potential Radioprotective Agent

2009 ◽  
Vol 172 (6) ◽  
pp. 698-705 ◽  
Author(s):  
K. Mishra ◽  
R. Bhardwaj ◽  
N. K. Chaudhury
Keyword(s):  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
A Minor ◽  
Radioprotective Agent

Development of a minor groove binding probe based real-time PCR for the diagnosis and quantification of Leishmania infantum in dog specimens

2011 ◽  
Vol 91 (2) ◽  
pp. 243-245 ◽  
Author(s):  
Elena Galletti ◽  
Paolo Bonilauri ◽  
Lia Bardasi ◽  
Maria Cristina Fontana ◽  
Mattia Ramini ◽  
...  
Keyword(s):  
Real Time ◽  
Real Time Pcr ◽  
Leishmania Infantum ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
A Minor

scholarly journals Investigation of a minor groove-binding polyamide targeted to E2F1 transcription factor in chronic myeloid leukaemia (CML) cells

2018 ◽  
Vol 69 ◽  
pp. 119-122 ◽  
Author(s):  
Kourosh Hayatigolkhatmi ◽  
Giacomo Padroni ◽  
Wu Su ◽  
Lijing Fang ◽  
Eduardo Gómez-Castañeda ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Chronic Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
A Minor ◽  
E2f1 Transcription Factor

scholarly journals Direction of Intercalation of a bis-Ru(II) Complex to DNA Probed by a Minor Groove Binding Molecule 4',6-Diamidino-2-phenylindole

2013 ◽  
Vol 34 (10) ◽  
pp. 2895-2899
Author(s):  
Yoon Jung Jang ◽  
Raeyeong Kim ◽  
Nataraj Chitrapriya ◽  
Sung Wook Han ◽  
Seog K. Kim ◽  
...  
Keyword(s):  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
A Minor

Development and application of a one-step real-time RT-PCR using a minor-groove-binding probe for the detection of a novel bunyavirus in clinical specimens

2012 ◽  
Vol 85 (2) ◽  
pp. 370-377 ◽  
Author(s):  
Zhifeng Li ◽  
Lunbiao Cui ◽  
Minghao Zhou ◽  
Xian Qi ◽  
Changjun Bao ◽  
...  
Keyword(s):  
Real Time ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Rt Pcr ◽  
Groove Binding ◽  
Clinical Specimens ◽  
One Step ◽  
A Minor

scholarly journals Microarray analysis of the in vivo sequence preferences of a minor groove binding drug

BMC Genomics ◽  
2008 ◽  
Vol 9 (1) ◽  
pp. 32 ◽  
Author(s):  
Todd T Eckdahl ◽  
Adam D Brown ◽  
Steven N Hart ◽  
Kelly J Malloy ◽  
Martha Shott ◽  
...  
Keyword(s):  
Microarray Analysis ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
A Minor
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