Nucleic Acid Therapeutic Carriers with On-Demand Triggered Release

2009 ◽  
Vol 20 (9) ◽  
pp. 1773-1782 ◽  
Author(s):  
Siddarth Venkatesh ◽  
Jacek Wower ◽  
Mark E. Byrne
Keyword(s):  
Nucleic Acid ◽  
Triggered Release ◽  
On Demand

scholarly journals Photoswitchable Particles for On-Demand Degradation and Triggered Release

Small ◽  
2013 ◽  
Vol 9 (18) ◽  
pp. 3051-3057 ◽  
Author(s):  
Tae-Hong Park ◽  
Thomas W. Eyster ◽  
Joshua M. Lumley ◽  
Sangyeul Hwang ◽  
Kyung Jin Lee ◽  
...  
Keyword(s):  
Triggered Release ◽  
On Demand

scholarly journals Poly(ε-caprolactone) (PCL) Hollow Nanoparticles with Surface Sealability and On-Demand Pore Generability for Easy Loading and NIR Light-Triggered Release of Drug

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 528 ◽  
Author(s):  
Ju Hyang Park ◽  
Da In Kim ◽  
Sang Gi Hong ◽  
Hojun Seo ◽  
Jongbok Kim ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Synergistic Activity ◽  
Triggered Release ◽  
Hollow Nanoparticles ◽  
Anticancer Efficacy ◽  
Hollow Particles ◽  
On Demand ◽  
Drug Molecules ◽  
Nir Light ◽  
New System

A new system for the easy loading and NIR light-triggered release of drugs is introduced. It consists of poly(ε-caprolactone) (PCL) hollow nanoparticles with surface openings containing a biodegradable fatty acid with phase-change ability and a biocompatible photothermal agent. These openings, which can enhance the connectivity between the interior and the exterior, enable the easy loading of drug molecules into the interior voids, and their successive sealing ensures a stable encapsulation of the drug. Upon exposure to an external NIR light irradiation, the photothermal agent generates heat that raises the local temperature of the hollow particles above the melting point of the fatty acid, leading to the formation of nanopores on their shells, and consequently, the instant release of the encapsulated drug molecules through the pores. The synergistic activity of the hyperthermia effect from the photothermal agent and the NIR-triggered release of the drug molecules results in noticeable anticancer efficacy.

scholarly journals Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Wei Zhang ◽  
Tianjiao Ji ◽  
Yang Li ◽  
Yueqin Zheng ◽  
Manisha Mehta ◽  
...  
Keyword(s):  
Local Anesthesia ◽  
Local Anesthetics ◽  
Triggered Release ◽  
On Demand ◽  
Macromolecular Prodrug

Triggered-release polymeric conjugate micelles for on-demand intracellular drug delivery

2015 ◽  
Vol 26 (11) ◽  
pp. 115101 ◽  
Author(s):  
Yanwu Cao ◽  
Min Gao ◽  
Chao Chen ◽  
Aiping Fan ◽  
Ju Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Triggered Release ◽  
On Demand ◽  
Intracellular Drug Delivery ◽  
Polymeric Conjugate

Radiofrequency-triggered release for on-demand delivery of therapeutics from titania nanotube drug-eluting implants

Nanomedicine ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. 1263-1275 ◽  
Author(s):  
Manpreet Bariana ◽  
Moom Sinn Aw ◽  
Eli Moore ◽  
Nicolas H Voelcker ◽  
Dusan Losic
Keyword(s):  
Triggered Release ◽  
On Demand ◽  
Titania Nanotube ◽  
Drug Eluting

ChemInform Abstract: Responsive Polyelectrolyte Complexes for Triggered Release of Nucleic Acid Therapeutics

ChemInform ◽  
2010 ◽  
Vol 41 (48) ◽  
pp. no-no
Author(s):  
Mahmoud Soliman ◽  
Stephanie Allen ◽  
Martyn C. Davies ◽  
Cameron Alexander
Keyword(s):  
Nucleic Acid ◽  
Triggered Release ◽  
Polyelectrolyte Complexes ◽  
Nucleic Acid Therapeutics

Responsive polyelectrolyte complexes for triggered release of nucleic acid therapeutics

2010 ◽  
Vol 46 (30) ◽  
pp. 5421 ◽  
Author(s):  
Mahmoud Soliman ◽  
Stephanie Allen ◽  
Martyn C. Davies ◽  
Cameron Alexander
Keyword(s):  
Nucleic Acid ◽  
Triggered Release ◽  
Polyelectrolyte Complexes ◽  
Nucleic Acid Therapeutics

Hierarchical construction of a mechanically stable peptide–graphene oxide hybrid hydrogel for drug delivery and pulsatile triggered release in vivo

Nanoscale ◽  
2015 ◽  
Vol 7 (5) ◽  
pp. 1655-1660 ◽  
Author(s):  
Junhua Wu ◽  
Aiping Chen ◽  
Meng Qin ◽  
Rong Huang ◽  
Guang Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
High Stability ◽  
Control Release ◽  
Drug Control ◽  
Triggered Release ◽  
Hybrid Hydrogel ◽  
On Demand

A peptide–graphene oxide hybrid hydrogel that possesses high stability and drug-sustainability was engineered for on-demand drug control release.

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