Development and Characterization of New Cyclodextrin Polymer-Based DNA Delivery Systems

2008 ◽  
Vol 19 (12) ◽  
pp. 2311-2320 ◽  
Author(s):  
Virginie Burckbuchler ◽  
Véronique Wintgens ◽  
Christian Leborgne ◽  
Sophie Lecomte ◽  
Nadine Leygue ◽  
...  
Keyword(s):  
Dna Delivery ◽  
Delivery Systems ◽  
Cyclodextrin Polymer

Structural characterization of novel gemini non-viral DNA delivery systems for cutaneous gene therapy

2006 ◽  
Vol 1 (2) ◽  
pp. 165-176 ◽  
Author(s):  
Marianna Foldvari ◽  
Ildiko Badea ◽  
Shawn Wettig ◽  
Ronald Verrall ◽  
Mukasa Bagonluri
Keyword(s):  
Gene Therapy ◽  
Structural Characterization ◽  
Dna Delivery ◽  
Delivery Systems ◽  
Viral Dna

Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems

2018 ◽  
Vol 69 (7) ◽  
pp. 1756-1759 ◽  
Author(s):  
Luminita Confederat ◽  
Iuliana Motrescu ◽  
Sandra Constantin ◽  
Florentina Lupascu ◽  
Lenuta Profire
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Average Diameter ◽  
Delivery Systems ◽  
Cross Linking ◽  
Low Molecular Weight ◽  
Polymeric Systems ◽  
Chitosan Microparticles ◽  
Degree Of Swelling

The aim of this study was to optimize the method used for obtaining microparticles based on chitosan � a biocompatible, biodegradable, and nontoxic polymer, and to characterize the developed systems. Chitosan microparticles, as drug delivery systems were obtained by inotropic gelation method using pentasodiumtripolyphosphate (TPP) as cross-linking agent. Chitosan with low molecular weight (CSLMW) in concentration which ranged between 0.5 and 5 %, was used while the concentration of cross-linking agent ranged between 1 and 5%. The characterization of the microparticles in terms of shape, uniformity and adhesion was performed in solution and dried state. The size of the microparticles and the degree of swelling were also determined. The structure and the morphology of the developed polymeric systems were analyzed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).The average diameter of the chitosan microparticles was around 522 �m. The most stable microparticles were obtained using CSLMW 1% and TPP 2% or CSLMW 0.75%and TPP 1%. The micropaticles were spherical, uniform and without flattening. Using CSLMW in concentration of 0.5 % poorly cross-linked and crushed microparticles have been obtained at all TPP concentrations. By optimization of the method, stable chitosan-based micropaticles were obtained which will be used to develop controlled release systems for drug delivery.

Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems

2021 ◽  
Vol 32 (5) ◽  
pp. 1924-1950
Author(s):  
Amir Ghaderpour ◽  
Zohreh Hoseinkhani ◽  
Reza Yarani ◽  
Sina Mohammadiani ◽  
Farshid Amiri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Gene Delivery ◽  
Delivery Systems

Preparation and Biophysical Characterization of Quercetin Inclusion Complexes with β-Cyclodextrin Derivatives to be Formulated as Possible Nose-to-Brain Quercetin Delivery Systems

2020 ◽  
Vol 17 (11) ◽  
pp. 4241-4255
Author(s):  
Konstantina Manta ◽  
Paraskevi Papakyriakopoulou ◽  
Maria Chountoulesi ◽  
Dimitrios A. Diamantis ◽  
Dimitrios Spaneas ◽  
...  
Keyword(s):  
Inclusion Complexes ◽  
Delivery Systems ◽  
Cyclodextrin Derivatives ◽  
Biophysical Characterization
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