scholarly journals Click Chemistry for18F-Labeling of RGD Peptides and microPET Imaging of Tumor Integrin αvβ3Expression

2007 ◽  
Vol 18 (6) ◽  
pp. 1987-1994 ◽  
Author(s):  
Zi-Bo Li ◽  
Zhanhong Wu ◽  
Kai Chen ◽  
Frederick T. Chin ◽  
Xiaoyuan Chen
Keyword(s):  
Click Chemistry ◽  
Rgd Peptides ◽  
Micropet Imaging

scholarly journals MicroPET Imaging of Integrin αvβ3 Expressing Tumors Using 89Zr-RGD Peptides

2010 ◽  
Vol 13 (6) ◽  
pp. 1224-1233 ◽  
Author(s):  
Orit Jacobson ◽  
Lei Zhu ◽  
Gang Niu ◽  
Ido D. Weiss ◽  
Lawrence P. Szajek ◽  
...  
Keyword(s):  
Integrin Αvβ3 ◽  
Rgd Peptides ◽  
Micropet Imaging

Facile Method To Radiolabel Glycol Chitosan Nanoparticles with 64Cu via Copper-Free Click Chemistry for MicroPET Imaging

2013 ◽  
Vol 10 (6) ◽  
pp. 2190-2198 ◽  
Author(s):  
Dong-Eun Lee ◽  
Jin Hee Na ◽  
Sangmin Lee ◽  
Choong Mo Kang ◽  
Hun Nyun Kim ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Chitosan Nanoparticles ◽  
Glycol Chitosan ◽  
Micropet Imaging

A direct comparison of tumor angiogenesis with 68Ga-labeled NGR and RGD peptides in HT-1080 tumor xenografts using microPET imaging

Amino Acids ◽  
2014 ◽  
Vol 46 (10) ◽  
pp. 2355-2364 ◽  
Author(s):  
Yahui Shao ◽  
Wansheng Liang ◽  
Fei Kang ◽  
Weidong Yang ◽  
Xiaowei Ma ◽  
...  
Keyword(s):  
Tumor Angiogenesis ◽  
Rgd Peptides ◽  
Micropet Imaging ◽  
Tumor Xenografts

MicroPET imaging of breast cancer ?-integrin expression with Cu-labeled dimeric RGD peptides

2004 ◽  
Vol 6 (5) ◽  
pp. 350-359 ◽  
Author(s):  
X CHEN ◽  
S LIU ◽  
Y HOU ◽  
M TOHME ◽  
R PARK ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Integrin Expression ◽  
Rgd Peptides ◽  
Micropet Imaging

Click Chemistry Expedited Radiosynthesis: Sulfur [18F]fluoride Exchange of Aryl Fluorosulfates

2019 ◽  
Author(s):  
Qinheng Zheng ◽  
Hongtao Xu ◽  
Hua Wang ◽  
Wen-Ge Han Du ◽  
Nan Wang ◽  
...  
Keyword(s):  
Click Chemistry ◽  
High Performance ◽  
Isotopic Exchange ◽  
Tumor Imaging ◽  
Radiochemical Yield ◽  
Exchange Method ◽  
Molar Activity ◽  
Positron Emission ◽  
Sulfur Fluoride

The lack of simple, efficient [<sup>18</sup>F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [<sup>18</sup>F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated <sup>18</sup>F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol<sup>–1</sup>) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [<sup>18</sup>F]fluorosulfate is demonstrated by the <i>in vivo</i> tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).

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