Synthesis, Characterization, and in Vitro Evaluation of Long-Chain Hyperbranched Poly(ethylene glycol) as Drug Carrier

2010 ◽  
Vol 21 (11) ◽  
pp. 2093-2102 ◽  
Author(s):  
Yan Pang ◽  
Jinyao Liu ◽  
Jieli Wu ◽  
Guolin Li ◽  
Ruibin Wang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Drug Carrier ◽  
Poly Ethylene Glycol ◽  
In Vitro Evaluation ◽  
Hyperbranched Poly ◽  
Poly Ethylene ◽  
Long Chain

Cationic long-chain hyperbranched poly(ethylene glycol)s with low charge density for gene delivery

2013 ◽  
Vol 4 (2) ◽  
pp. 393-401 ◽  
Author(s):  
Chunlai Tu ◽  
Nan Li ◽  
Lijuan Zhu ◽  
Linzhu Zhou ◽  
Yue Su ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Charge Density ◽  
Poly Ethylene Glycol ◽  
Hyperbranched Poly ◽  
Poly Ethylene ◽  
Low Charge ◽  
Long Chain

scholarly journals Polypeptides Micelles Composed of Methoxy-Poly(Ethylene Glycol)-Poly(l-Glutamic Acid)-Poly(l-Phenylalanine) Triblock Polymer for Sustained Drug Delivery

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 230 ◽  
Author(s):  
Xingzheng Liu ◽  
Rongrong Fan ◽  
Boting Lu ◽  
Yuan Le
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Drug Carrier ◽  
Drug Loading ◽  
Poly Ethylene Glycol ◽  
Sustained Drug Release ◽  
Poly Ethylene ◽  
Triblock Polymers

Methoxy-poly(ethylene glycol)-poly(l-glutamic acid)-poly(l-phenylalanine) triblock polymers with different architecture were synthesized as drug carrier to obtain sustained and controlled release by tuning the composition. These triblock polymers were prepared by ring opening polymerization and poly(ethylene glycol) was used as an initiator. Polymerization was confirmed by 1H NMR, FT-IR and gel penetration chromatography. The polymers can self-assemble to form micelles in aqueous medium and their critical micelle concentrations values were examined. The micelles were spherical shape with size of 50–100 nm and especially can arranged in a regular manner. Sorafenib was selected as the model drug and the drug loading performance was dependent on the composition of the block copolymer. In vitro drug release indicated that the polymers can realize controlled and sustained drug release. Furthermore, in vitro cytotoxicity assay showed that the polymers were biocompatible and the drug-loaded micelles can increase toxicity towards tumor cells. Confocal fluorescence microscopy assays illustrated that the micelles can be uptaken quickly and release drug persistently to inhibit tumor cell growth.

In vitro evaluation of poly(ethylene glycol)-block-poly(ɛ-caprolactone) methyl ether copolymer coating effects on cells adhesion and proliferation

2016 ◽  
Vol 374 ◽  
pp. 23-30 ◽  
Author(s):  
Laurentiu Rusen ◽  
Patricia Neacsu ◽  
Anisoara Cimpean ◽  
Ion Valentin ◽  
Simona Brajnicov ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Methyl Ether ◽  
Poly Ethylene Glycol ◽  
In Vitro Evaluation ◽  
Copolymer Coating ◽  
Poly Ethylene

Hyperbranched Poly(ethylene glycol)s:  A New Class of Ion-Conducting Materials

1996 ◽  
Vol 29 (11) ◽  
pp. 3831-3838 ◽  
Author(s):  
Craig J. Hawker ◽  
Fengkui Chu ◽  
Peter J. Pomery ◽  
David J. T. Hill
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
New Class ◽  
Hyperbranched Poly ◽  
Conducting Materials ◽  
Ion Conducting ◽  
Poly Ethylene
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