scholarly journals Optical Imaging of Bacterial Infection in Living Mice Using Deep-Red Fluorescent Squaraine Rotaxane Probes

2010 ◽  
Vol 21 (7) ◽  
pp. 1297-1304 ◽  
Author(s):  
Alexander G. White ◽  
Na Fu ◽  
W. Matthew Leevy ◽  
Jung-Jae Lee ◽  
Michael A. Blasco ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Optical Imaging ◽  
Squaraine Rotaxane

In Vivo Monitoring the Process of Tumor Growth, Metastasis and Bacterial Infection Expressing GFP via Real-Time Optical Imaging

2013 ◽  
Vol 9 (2) ◽  
pp. 274-280 ◽  
Author(s):  
Tao Xiong ◽  
Yongjin Li ◽  
Zhiyang Li ◽  
Xiangmo Xie ◽  
Lisha Lu
Keyword(s):  
Tumor Growth ◽  
Bacterial Infection ◽  
Optical Imaging ◽  
Real Time

In vivo optical imaging of bacterial infection and antibiotic response in intact nude mice

2005 ◽  
Author(s):  
Tao Xiong ◽  
Yanping Chen ◽  
Jun Chu ◽  
Zhihong Zhang ◽  
Bifeng Liu ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Optical Imaging ◽  
Nude Mice ◽  
Antibiotic Response ◽  
In Vivo Optical Imaging

scholarly journals Optical Imaging of Bacterial Infection in Living Mice Using a Fluorescent Near-Infrared Molecular Probe

2006 ◽  
Vol 128 (51) ◽  
pp. 16476-16477 ◽  
Author(s):  
W. Matthew Leevy ◽  
Seth T. Gammon ◽  
Hua Jiang ◽  
James R. Johnson ◽  
Dustin J. Maxwell ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Optical Imaging ◽  
Near Infrared ◽  
Molecular Probe

scholarly journals NONINVASIVE OPTICAL IMAGING OF STAPHYLOCOCCUS AUREUS INFECTION IN VIVO USING AN ANTIMICROBIAL PEPTIDE FRAGMENT BASED NEAR-INFRARED FLUORESCENT PROBES

2013 ◽  
Vol 06 (03) ◽  
pp. 1350026 ◽  
Author(s):  
CUICUI LIU ◽  
YUEQING GU
Keyword(s):  
Staphylococcus Aureus ◽  
Bacterial Infection ◽  
Antimicrobial Peptide ◽  
Optical Imaging ◽  
Bacterial Infections ◽  
Near Infrared ◽  
Peptide Fragment ◽  
Imaging Probe ◽  
Aureus Infection

The diagnosis of bacterial infections remains a major challenge in medicine. Optical imaging of bacterial infection in living animals is usually conducted with genetic reporters such as light-emitting enzymes or fluorescent proteins. However, there are many circumstances where genetic reporters are not applicable, and there is an urgent need for exogenous synthetic probes that can selectively target bacteria. Optical imaging of bacteria in vivo is much less developed than methods such as radioimaging and MRI. Furthermore near-infrared (NIR) dyes with emission wavelengths in the region of 650–900 nm can propagate through two or more centimeters of tissue and may enable deeper tissue imaging if sensitive detection techniques are employed. Here we constructed an antimicrobial peptide fragment UBI29-41-based near-infrared fluorescent imaging probe. The probe is composed of UBI29-41 conjugated to a near infrared dye ICG-Der-02. UBI29-41 is a cationic antimicrobial peptide that targets the anionic surfaces of bacterial cells. The probe allows detection of Staphylococcus aureus infection (5 × 107 cells) in a mouse local infection model using whole animal near-infrared fluorescence imaging. Furthermore, we demonstrate that the UBI29-41-based imaging probe can selectively accumulate within bacteria. The significantly higher accumulation in bacterial infection suggests that UBI29-41-based imaging probe may be a promising imaging agent to detect bacterial infections.

scholarly journals Optical imaging of bacterial infection models

2007 ◽  
Vol 4 (3) ◽  
pp. 91-97 ◽  
Author(s):  
W. Matthew Leevy ◽  
Nathan Serazin ◽  
Bradley D. Smith
Keyword(s):  
Bacterial Infection ◽  
Optical Imaging ◽  
Infection Models

1096: Whole Body Optical Imaging of Skeletal Metastases: Pathogenic Relationship with Bone Turnover and Therapeutic Rationale

2004 ◽  
Vol 171 (4S) ◽  
pp. 289-289
Author(s):  
Gabri van der Pluijm ◽  
Antoinette Wetterwald ◽  
George N. Thalmann ◽  
Guus Lycklama A. Nijeholt ◽  
Rob Pelger ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Optical Imaging ◽  
Whole Body ◽  
Skeletal Metastases
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