scholarly journals 64Cu-Labeled Alpha-Melanocyte-Stimulating Hormone Analog for MicroPET Imaging of Melanocortin 1 Receptor Expression

2007 ◽  
Vol 18 (3) ◽  
pp. 765-772 ◽  
Author(s):  
Zhen Cheng ◽  
Zhengming Xiong ◽  
Murugesan Subbarayan ◽  
Xiaoyuan Chen ◽  
Sanjiv Sam Gambhir
Keyword(s):  
Receptor Expression ◽  
Melanocortin 1 Receptor ◽  
Micropet Imaging ◽  
Melanocyte Stimulating Hormone ◽  
Hormone Analog ◽  
Stimulating Hormone

scholarly journals A novel mechanism in control of human pigmentation by β-melanocyte-stimulating hormone and 7-tetrahydrobiopterin

2005 ◽  
Vol 187 (2) ◽  
pp. 293-302 ◽  
Author(s):  
Jennifer D Spencer ◽  
Bhaven Chavan ◽  
Lee K Marles ◽  
Sobia Kauser ◽  
Hartmut Rokos ◽  
...  
Keyword(s):  
Opiate Receptor ◽  
Melanocortin 1 Receptor ◽  
Melanocyte Stimulating Hormone ◽  
Receptor Signal ◽  
Major Player ◽  
Key Enzyme ◽  
Μ Opiate Receptor ◽  
Inhibition Reaction ◽  
Stimulating Hormone

The human skin holds the full machinery for pro-opiomelanocortin processing. The α-melanocyte-stimulating hormone (α-MSH)/melanocortin-1-receptor cascade has been implicated as a major player via the cAMP signal in the control of melanogenesis. Only very recently the β-endorphin/μ-opiate receptor signal has been added to the list of regulators of melanocyte dendricity and melanin formation. In this context it was reported that (6R)-l-erythro-5,6,7,8-tetrahydrobiopterin (6BH4) can act as an allosteric inhibitor of tyrosinase, the key enzyme in melanogenesis, and this inhibition is reversible by both α- and β-MSH. It was also shown earlier that 7BH4, the isomer of 6BH4, is twice as active in this inhibition reaction. However, as yet it is not known whether 7BH4 is indeed present in loco in the melanosome. We here provide evidence that this isomer is present in this organelle in a concentration range up to 50 × 10−6 M. Determination of β-MSH in melanosomal extracts yielded 10 pg/mg protein. Moreover, we demonstrate reactivation of the 7BH4/tyrosinase inhibitor complex by β-MSH, whereas α-MSH failed to do so. Furthermore, we show intra-melanosomal l-dopa formation from dopachrome by 7BH4 in a concentration range up to 134 × 10−6 M. Based on these results, we propose a new receptor-independent mechanism in the control of tyrosinase/melanogenesis by β-MSH and the pterin 7BH4.

Influence of the Bifunctional Chelator on the Pharmacokinetic Properties of 99mTc(CO)3-Labeled Cyclic α-Melanocyte Stimulating Hormone Analog

2013 ◽  
Vol 56 (5) ◽  
pp. 1961-1973 ◽  
Author(s):  
Maurício Morais ◽  
Bruno L. Oliveira ◽  
João D. G. Correia ◽  
Maria Cristina Oliveira ◽  
Maria Angeles Jiménez ◽  
...  
Keyword(s):  
Bifunctional Chelator ◽  
Melanocyte Stimulating Hormone ◽  
Hormone Analog ◽  
Pharmacokinetic Properties ◽  
Stimulating Hormone

scholarly journals An Unusual Conformation of γ-Melanocyte-Stimulating Hormone Analogues Leads to a Selective Human Melanocortin 1 Receptor Antagonist for Targeting Melanoma Cells

Biochemistry ◽  
2013 ◽  
Vol 52 (4) ◽  
pp. 752-764 ◽  
Author(s):  
Minying Cai ◽  
Magda Stankova ◽  
Dhanasekaran Muthu ◽  
Alexander Mayorov ◽  
Zhehui Yang ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Melanoma Cells ◽  
Melanocortin 1 Receptor ◽  
Melanocyte Stimulating Hormone ◽  
Stimulating Hormone

Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction

Urology ◽  
2000 ◽  
Vol 56 (4) ◽  
pp. 641-646 ◽  
Author(s):  
Hunter Wessells ◽  
Dan Gralnek ◽  
Robert Dorr ◽  
Victor J Hruby ◽  
Mac E Hadley ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Sexual Desire ◽  
Penile Erection ◽  
Melanocyte Stimulating Hormone ◽  
Hormone Analog ◽  
Stimulating Hormone
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