Epidermal Growth Factor-Conjugated Poly(ethylene glycol)-block- Poly(δ-valerolactone) Copolymer Micelles for Targeted Delivery of Chemotherapeutics

2006 ◽  
Vol 17 (2) ◽  
pp. 399-409 ◽  
Author(s):  
Faquan Zeng ◽  
Helen Lee ◽  
Christine Allen
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Ethylene Glycol ◽  
Targeted Delivery ◽  
Poly Ethylene Glycol ◽  
Epidermal Growth ◽  
Copolymer Micelles ◽  
Poly Ethylene

Reversibly cross-linked poly(ethylene glycol)–poly(amino acid)s copolymer micelles: a promising approach to overcome the extracellular stability versus intracellular drug release challenge

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 20025-20034 ◽  
Author(s):  
Yuling Li ◽  
Sai Wang ◽  
Dandan Zhu ◽  
Yuling Shen ◽  
Baixiang Du ◽  
...  
Keyword(s):  
Amino Acid ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Lipoic Acid ◽  
Triblock Copolymer ◽  
Intracellular Delivery ◽  
Poly Ethylene Glycol ◽  
Copolymer Micelles ◽  
Poly Ethylene ◽  
Copolymer Poly

Reversibly shell cross-linked micelles based on a lipoic acid (LA) decorated triblock copolymer poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamate)-b-poly(l-phenylalanine) have been developed for efficient intracellular delivery of DOX.

Magnetic Epidermal Growth Factor Conjugate for Targeted Delivery to Grafted Tumor in Mouse Model

2013 ◽  
Vol 49 (1) ◽  
pp. 429-435 ◽  
Author(s):  
Boris. P. Nikolaev ◽  
Yaroslav Yu Marchenko ◽  
Liudmila Yu Yakovleva ◽  
Tatiana M. Zimina ◽  
Alexei V. Soloviev ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Mouse Model ◽  
Targeted Delivery ◽  
Epidermal Growth

scholarly journals A modular, plasmin-sensitive, clickable poly(ethylene glycol)-heparin-laminin microsphere system for establishing growth factor gradients in nerve guidance conduits

Biomaterials ◽  
2015 ◽  
Vol 72 ◽  
pp. 112-124 ◽  
Author(s):  
Jacob L. Roam ◽  
Ying Yan ◽  
Peter K. Nguyen ◽  
Ian S. Kinstlinger ◽  
Michael K. Leuchter ◽  
...  
Keyword(s):  
Growth Factor ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals The Importance of Poly(ethylene glycol) and Lipid Structure in Targeted Gene Delivery to Lymph Nodes by Lipid Nanoparticles

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1068 ◽  
Author(s):  
Danijela Zukancic ◽  
Estelle J. A. Suys ◽  
Emily H. Pilkington ◽  
Azizah Algarni ◽  
Hareth Al-Wassiti ◽  
...  
Keyword(s):  
Lymph Node ◽  
Gene Delivery ◽  
Ethylene Glycol ◽  
Lymph Nodes ◽  
Injection Site ◽  
Targeted Delivery ◽  
Lipid Nanoparticles ◽  
Tween 20 ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Targeted delivery of nucleic acids to lymph nodes is critical for the development of effective vaccines and immunotherapies. However, it remains challenging to achieve selective lymph node delivery. Current gene delivery systems target mainly to the liver and typically exhibit off-target transfection at various tissues. Here we report novel lipid nanoparticles (LNPs) that can deliver plasmid DNA (pDNA) to a draining lymph node, thereby significantly enhancing transfection at this target organ, and substantially reducing gene expression at the intramuscular injection site (muscle). In particular, we discovered that LNPs stabilized by 3% Tween 20, a surfactant with a branched poly(ethylene glycol) (PEG) chain linking to a short lipid tail, achieved highly specific transfection at the lymph node. This was in contrast to conventional LNPs stabilized with a linear PEG chain and two saturated lipid tails (PEG-DSPE) that predominately transfected at the injection site (muscle). Interestingly, replacing Tween 20 with Tween 80, which has a longer unsaturated lipid tail, led to a much lower transfection efficiency. Our work demonstrates the importance of PEGylation in selective organ targeting of nanoparticles, provides new insights into the structure–property relationship of LNPs, and offers a novel, simple, and practical PEGylation technology to prepare the next generation of safe and effective vaccines against viruses or tumours.

Long-circulating poly(ethylene glycol)–poly(d,l-lactide) block copolymer micelles with modulated surface charge

2001 ◽  
Vol 77 (1-2) ◽  
pp. 27-38 ◽  
Author(s):  
Yuji Yamamoto ◽  
Yukio Nagasaki ◽  
Yukio Kato ◽  
Yuichi Sugiyama ◽  
Kazunori Kataoka
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Surface Charge ◽  
Poly Ethylene Glycol ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Poly Ethylene
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